Opportunity Information: Apply for PAR 14 008

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Secondary Data Analyses to Explore NIMH Research Domain Criteria (R03)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
  • This funding opportunity was created on Nov 22, 2013 and posted on Nov 22, 2013.
  • Applicants must submit their applications by Jan 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $50,000.00 in funding.
  • Eligible applicants include: Public and State controlled institutions of higher education Small businesses Native American tribal governments (Federally recognized) State governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments For profit organizations other than small businesses County governments Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Secondary Data Analyses to Explore NIMH Research Domain Criteria (R03) opportunity (Funding Opportunity Number PAR-14-008) was a National Institutes of Health, National Institute of Mental Health (NIMH) discretionary grant program designed to support small, focused projects that re-use existing clinical research datasets. The core goal was to encourage investigators to conduct secondary analyses that examine mental health and psychopathology through the lens of NIMH's Research Domain Criteria (RDoC) initiative, using already-collected data to explore RDoC constructs and to test new, theory-driven hypotheses grounded in the RDoC framework rather than relying solely on traditional diagnostic categories.

This program emphasized efficient, high-impact science by leveraging existing datasets instead of funding new data collection. Applicants were expected to identify suitable clinical research datasets (for example, studies that already include behavioral measures, clinical outcomes, neurocognitive tasks, physiological readouts, imaging data, or related phenotypes) and then apply RDoC-oriented questions to those data. In practice, this meant proposing analyses that map onto RDoC domains and constructs, such as negative valence systems, positive valence systems, cognitive systems, social processes, and arousal/regulatory systems, and examining relationships across multiple units of analysis when possible (for instance, linking symptom dimensions to behavioral task performance or biological signals). The intent was not merely to re-describe findings, but to use RDoC as an organizing framework to generate and test novel mechanistic or dimensional hypotheses about mental functioning and dysfunction.

The funding mechanism was the NIH R03, which typically supports short-term, limited-scope studies such as pilot projects, feasibility work, or discrete analyses. For this specific announcement, the listed award ceiling was $50,000, reflecting the expectation that proposed work would be tightly scoped and achievable with modest resources. Cost sharing or matching was not required, which is consistent with most NIH research grant mechanisms.

In terms of eligibility, the announcement was broad and inclusive. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than universities), small businesses, and various levels of government (state, county, city/township, special district, and independent school districts), as well as tribal governments and tribal organizations. The opportunity also explicitly allowed participation from a wide range of mission-focused institutions and communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs). Importantly, non-U.S. entities were eligible to apply, including foreign organizations and foreign institutions, and foreign components of U.S. organizations were allowed under NIH policy, signaling an openness to strong secondary-analysis proposals regardless of geography, as long as they aligned with NIH requirements.

Administratively, the funding activity category was Health (CFDA 93.242, Mental Health Research Grants). The opportunity was posted on November 22, 2013, and remained open through January 7, 2017, with an archive date of February 7, 2017. The full announcement was made available through the NIH grants guide, and NIH Office of Extramural Research (OER) webmaster contacts were provided for technical issues accessing or linking to the notice.

Overall, this grant opportunity was aimed at accelerating RDoC-relevant discovery by encouraging researchers to extract additional scientific value from existing clinical datasets. It was particularly well-suited for investigators who already had access to data (or could obtain access) and who could propose clear, methodologically sound analyses that use the RDoC framework to refine understanding of mental health-related constructs across dimensional and potentially transdiagnostic lines.

FAQs: Secondary Data Analyses to Explore NIMH Research Domain Criteria (R03) (PAR-14-008)

What is PAR-14-008?

PAR-14-008 is the Funding Opportunity Number for the National Institutes of Health (NIH), National Institute of Mental Health (NIMH) discretionary grant program titled "Secondary Data Analyses to Explore NIMH Research Domain Criteria (R03)." It was designed to fund small, focused projects that re-use existing clinical research datasets to answer research questions grounded in the NIMH Research Domain Criteria (RDoC) framework.

What was the main purpose of this grant opportunity?

The purpose was to encourage investigators to conduct secondary analyses of already-collected clinical research data in order to examine mental health and psychopathology using the RDoC initiative as the organizing framework. The intent was to support theory-driven, RDoC-informed hypotheses that go beyond traditional diagnostic categories.

What type of research did the program emphasize?

The program emphasized efficient, high-impact science that leverages existing datasets rather than funding new data collection. The expectation was that applicants would identify appropriate clinical research datasets and use them to explore RDoC constructs and domains in a focused and methodologically sound way.

Does this opportunity support new data collection?

The opportunity emphasized re-use of existing clinical research datasets instead of funding new data collection. Proposed projects were expected to rely on already-collected data and focus on secondary analyses aligned with RDoC.

What kinds of datasets were appropriate for the proposed secondary analyses?

Applicants were expected to identify suitable clinical research datasets that already included relevant measures. Examples mentioned include datasets containing behavioral measures, clinical outcomes, neurocognitive tasks, physiological readouts, imaging data, or related phenotypes.

What is the RDoC framework in the context of this program?

In this program, RDoC (Research Domain Criteria) served as the conceptual lens for designing analyses and hypotheses. Rather than relying only on traditional diagnostic categories, applicants were expected to frame questions around RDoC constructs and domains to better understand mental functioning and dysfunction in mechanistic and dimensional terms.

Which RDoC domains were specifically mentioned as examples?

The opportunity referenced analyses mapping onto RDoC domains and constructs such as negative valence systems, positive valence systems, cognitive systems, social processes, and arousal/regulatory systems.

Were applicants expected to link multiple "units of analysis" in their studies?

Yes, when possible. The announcement encouraged examining relationships across multiple units of analysis, such as linking symptom dimensions to behavioral task performance or biological signals, to better probe mechanisms and dimensional relationships under the RDoC framework.

Was the intent simply to re-describe existing findings from a dataset?

No. The stated intent was not merely to re-describe findings, but to use RDoC as an organizing framework to generate and test novel, theory-driven hypotheses about mental functioning and dysfunction.

What funding mechanism was used?

The funding mechanism was the NIH R03, which generally supports short-term, limited-scope studies such as pilot projects, feasibility work, or discrete analyses.

What was the award ceiling for this announcement?

The listed award ceiling for this specific announcement was $50,000, reflecting the expectation that the work would be tightly scoped and achievable with modest resources.

Was cost sharing or matching required?

No. Cost sharing or matching was not required, consistent with most NIH research grant mechanisms.

Who was eligible to apply?

Eligibility was broad. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than universities), small businesses, and multiple levels of government (state, county, city/township, special district, and independent school districts), as well as tribal governments and tribal organizations.

Were minority-serving institutions explicitly included as eligible applicants?

Yes. The announcement explicitly noted the ability of a wide range of mission-focused institutions and communities to participate, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs).

Could non-U.S. organizations apply?

Yes. Non-U.S. entities were eligible to apply, including foreign organizations and foreign institutions. In addition, foreign components of U.S. organizations were allowed under NIH policy.

What was the funding activity category and CFDA listing?

The funding activity category was Health. The CFDA listing provided was 93.242, Mental Health Research Grants.

When was the opportunity posted and when did it close?

The opportunity was posted on November 22, 2013, and remained open through January 7, 2017. The archive date was February 7, 2017.

Where was the full announcement made available?

The full announcement was made available through the NIH grants guide. The notice also referenced NIH Office of Extramural Research (OER) webmaster contacts for technical issues accessing or linking to the notice.

What kinds of investigators or teams was this opportunity best suited for?

Based on the description, it was particularly well-suited for investigators who already had access to clinical research data (or could obtain access) and could propose clear, focused secondary analyses using the RDoC framework to test new, theory-driven hypotheses.

What was the overarching scientific value the program aimed to deliver?

The program aimed to accelerate RDoC-relevant discovery by extracting additional scientific value from existing clinical datasets, enabling researchers to examine dimensional and potentially transdiagnostic relationships in mental health using RDoC constructs and domains.

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