Opportunity Information: Apply for PA 10 122
Apply for PA 10 122
- The National Institutes of Health in the education food and nutrition health income security and social services sector is offering a public funding opportunity titled "SHIFT Award Small Businesses Helping Investigators to Fuel the Translation of Scientific Discoveries SBIR R43/R44" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.389 National Center for Research Resources 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.855 Allergy, Immunology and Transplantation Research 93.856 Microbiology and Infectious Diseases Research 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Jan 7, 2013 and posted on Mar 5, 2010.
- Applicants must submit their applications by Jan 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Opportunity Summary:
The SHIFT Award (Small Businesses Helping Investigators to Fuel the Translation of Scientific Discoveries) is a National Institutes of Health (NIH) SBIR funding opportunity designed to move promising academic research toward real-world products and services. Its central goal is to support translational work, meaning research that is aimed at turning scientific discoveries into practical tools such as therapeutics, diagnostics, devices, software, or other health-related technologies with a clear path to commercialization. The program is built around the idea that many strong discoveries are born in universities and research institutes, but they often need a small business setting, focused development work, and commercial planning to become something patients, clinicians, and communities can actually use.
A defining feature of SHIFT is the career and employment transition requirement for the lead investigator. The program expects that an investigator who is primarily employed by a US research institution at the time of application will transition into a small business concern (SBC) and become primarily employed by that SBC (more than 50 percent of their time) by or at the time of award. In practical terms, NIH is not only funding a project but also encouraging a shift in where the project leadership sits: from an academic environment to a company environment. That requirement is meant to help ensure the work is driven by product development priorities, milestone-based execution, and the practical realities of commercialization, rather than staying indefinitely in a purely academic mode.
From the small business perspective, SHIFT is intended to help an SBC build up its internal scientific capacity and strengthen core competencies needed to advance a technology. The PD/PI (Project Director/Principal Investigator) can use the grant-supported structure to expand research staff, develop capabilities the company will need long-term, and formalize relationships that often matter in early commercialization. The announcement also highlights common translational necessities: licensing intellectual property (IP) that may have originated at the PD/PI's prior academic institution, maintaining or creating collaborations with academic investigators, and leveraging academic resources in a way that supports product development while the business takes the lead.
In terms of funding mechanism, this opportunity uses the SBIR R43/R44 grant structure, which corresponds to Phase I (R43), Phase II (R44), and Fast-Track applications. Phase I generally supports early proof-of-concept and feasibility work, Phase II supports more advanced R and D and product development steps, and Fast-Track is a combined approach that can accelerate movement from Phase I into Phase II when the development plan is strong and well-justified. The specific award levels and number of awards are not fixed in the notice; instead, NIH indicates that awards depend on the availability of funds and whether enough high-quality, meritorious applications are received. The total funding and award count can vary based on the proposed scope, duration, and budget needs across applications.
Eligibility is limited to small businesses, consistent with SBIR rules, and there is no cost-sharing or matching requirement stated for this opportunity. The activity categories listed with the opportunity span a wide range of NIH and health-related program areas, reflecting that SHIFT can apply across many biomedical and behavioral research domains where translation to market is realistic. The CFDA program listings included cover areas such as complementary and integrative health, alcohol and drug abuse research, cardiovascular and pulmonary diseases, blood disorders, arthritis and musculoskeletal conditions, diabetes and kidney diseases, allergy and immunology, infectious diseases, general biomedical research and training, child health and development, and aging research, among others. That breadth signals that SHIFT is not confined to a single disease area; it is more about the translational and commercialization intent and the investigator-to-small-business transition model.
Administratively, the funding opportunity number is PA-10-122, the agency is NIH, and it was originally posted March 5, 2010. The opportunity record shows an original closing date of January 7, 2013, a current closing date of January 7, 2014, and an archive date of February 7, 2014, indicating it is a historical opportunity rather than an open, current solicitation today. The original announcement link referenced is http://grants.nih.gov/grants/guide/pa-files/PA-10-122.html, and NIH’s Office of Extramural Research (OER) webmaster contact is provided for access or linking issues.
SHIFT Award (NIH SBIR) - Frequently Asked Questions
What is the SHIFT Award?
The SHIFT Award (Small Businesses Helping Investigators to Fuel the Translation of Scientific Discoveries) is an NIH Small Business Innovation Research (SBIR) funding opportunity intended to move promising academic research toward real-world products and services. It focuses on translational work that turns scientific discoveries into practical health-related technologies with a clear path to commercialization.
What is the main goal of the SHIFT program?
The program aims to support translational research and development that leads to commercially viable tools such as therapeutics, diagnostics, devices, software, or other health-related technologies. The emphasis is on product-driven development, milestone-based execution, and commercialization planning.
What does "translational work" mean in the context of this opportunity?
In this opportunity, translational work means development activities aimed at converting scientific discoveries into practical products or services that can be used by patients, clinicians, and communities, and that have a realistic route to market.
Who is the intended applicant organization type for SHIFT?
Eligibility is limited to small businesses, consistent with SBIR rules. The program is structured for a small business concern (SBC) to lead the work in a company setting rather than an academic setting.
What is the defining investigator employment transition requirement under SHIFT?
A defining feature is the career and employment transition expectation for the lead investigator (PD/PI). If the investigator is primarily employed by a US research institution at the time of application, NIH expects that investigator to transition into a small business concern and become primarily employed by that SBC (more than 50 percent of their time) by or at the time of award.
When does the PD/PI need to be primarily employed by the small business?
The program expects the PD/PI to be primarily employed by the small business (more than 50 percent time) by or at the time of award, if they were primarily employed by a US research institution at the time of application.
Why does SHIFT require the investigator to transition from academia to a small business?
The requirement is intended to shift project leadership into a company environment so the work is driven by product development priorities, milestone-based execution, and commercialization realities, rather than remaining indefinitely in a purely academic mode.
How does SHIFT help a small business build capacity?
From the small business perspective, SHIFT is intended to help an SBC build internal scientific capacity and strengthen the core competencies needed to advance a technology. The grant-supported structure can support expansion of research staff, development of long-term capabilities, and formalization of relationships important for early commercialization.
What kinds of activities and needs does NIH highlight as common in translation?
The description highlights needs such as licensing intellectual property (IP) that may have originated at the PD/PI's prior academic institution, maintaining or creating collaborations with academic investigators, and leveraging academic resources in a way that supports product development while the business takes the lead.
Does SHIFT support licensing or use of university intellectual property?
The opportunity notes that licensing IP originating at the PD/PI's prior academic institution is a common translational necessity, and it acknowledges that such IP arrangements may be part of moving a discovery into a company-led product development effort.
Are academic collaborations allowed or expected under SHIFT?
The opportunity describes maintaining or creating collaborations with academic investigators and leveraging academic resources as common translational necessities, while emphasizing that the small business should take the lead in product development.
What NIH SBIR funding mechanisms are used for SHIFT?
SHIFT uses the SBIR R43/R44 grant structure. This corresponds to Phase I (R43), Phase II (R44), and Fast-Track applications.
What is supported in SBIR Phase I (R43) under this opportunity?
Phase I (R43) generally supports early proof-of-concept and feasibility work.
What is supported in SBIR Phase II (R44) under this opportunity?
Phase II (R44) generally supports more advanced research and development (R&D) and additional product development steps beyond initial feasibility.
What is a Fast-Track application in the SHIFT context?
Fast-Track is a combined approach that can accelerate movement from Phase I into Phase II when the development plan is strong and well-justified. It is intended to streamline progression when the project is ready for a more continuous development path.
Are the award amounts and number of awards fixed for SHIFT?
No. The notice indicates that specific award levels and the number of awards are not fixed. Awards depend on the availability of funds and whether enough high-quality, meritorious applications are received.
What determines the total funding and award count for this opportunity?
The total funding and number of awards can vary based on the proposed scope, duration, and budget needs across applications, as well as NIH funding availability and the quality of submitted applications.
Is cost-sharing or matching required?
No cost-sharing or matching requirement is stated for this opportunity.
What research or disease areas can SHIFT apply to?
The activity categories span a wide range of NIH and health-related program areas, indicating the opportunity is not confined to a single disease area. It is oriented around translational and commercialization intent and the investigator-to-small-business transition model. The included program listings cover areas such as complementary and integrative health, alcohol and drug abuse research, cardiovascular and pulmonary diseases, blood disorders, arthritis and musculoskeletal conditions, diabetes and kidney diseases, allergy and immunology, infectious diseases, general biomedical research and training, child health and development, and aging research, among others.
Is SHIFT limited to a specific NIH institute or a single topic?
Based on the broad range of activity categories and program listings, SHIFT is intended to apply across many biomedical and behavioral research domains where translation to market is realistic, rather than being limited to one narrow topic area.
What is the funding opportunity number and agency for SHIFT?
The funding opportunity number is PA-10-122, and the agency is the National Institutes of Health (NIH).
When was this funding opportunity posted?
The opportunity was originally posted on March 5, 2010.
Is this opportunity currently open?
No. The record indicates this is a historical opportunity rather than a current open solicitation. It shows an original closing date of January 7, 2013, a current closing date of January 7, 2014, and an archive date of February 7, 2014.
Where can the original NIH announcement be found?
The original announcement link referenced is http://grants.nih.gov/grants/guide/pa-files/PA-10-122.html.
Who is listed as the contact for access or linking issues?
The NIH Office of Extramural Research (OER) webmaster contact is provided for access or linking issues in the opportunity record.
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