Opportunity Information: Apply for PA 11 013
Apply for PA 11 013
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Sickle Cell Disease Inflammation, Thrombosis and Vascular Dysfunction, NHLBI (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Oct 26, 2010 and posted on Oct 26, 2010.
- Applicants must submit their applications by May 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal governments (Federally recognized) State governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments County governments Public housing authorities/Indian housing authorities City or township governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Sickle Cell Disease Inflammation, Thrombosis and Vascular Dysfunction, NHLBI (R01) funding opportunity (PA 11-013) was a discretionary NIH grant announcement designed to support research that goes beyond the classic focus on red blood cell sickling alone. The central idea behind the program was that sickle cell disease (SCD) complications are driven not only by the mechanical and rheological effects of sickled red blood cells, but also by broader biological processes such as inflammation, coagulation and thrombosis, endothelial and vascular dysfunction, and immune-related pathways. The announcement specifically emphasized the need to discover and define new pathways and regulatory mechanisms that may be just as important to SCD pathophysiology as the sickling event itself, with the long-term aim of enabling better-targeted therapeutic strategies and improved clinical outcomes.
A key feature of this FOA was its encouragement of genuinely collaborative, team-based projects. Rather than supporting isolated work within a single discipline, it called for studies that bring together established SCD investigators with researchers from complementary fields, particularly biochemical, biophysical, and immunological disciplines. In practical terms, this meant proposals were expected to integrate expertise across areas like molecular and cellular signaling, vascular biology, platelet and coagulation biology, endothelial activation, immune cell behavior, inflammatory mediators, and biophysical interactions between blood cells and the vessel wall. The expectation was that cross-disciplinary approaches would be more likely to uncover mechanisms that have been missed when SCD is viewed mainly through the lens of hemoglobin polymerization and red cell deformation.
The award mechanism was the NIH R01 research project grant, which generally supports hypothesis-driven, investigator-initiated projects of significant scope. The activity category was Health, and the CFDA listing associated with the program was 93.839 (Blood Diseases and Resources Research). No cost sharing or matching was required, which is consistent with standard NIH research project grants. The announcement was posted on October 26, 2010, with an original and current closing date of May 7, 2011, and it was archived on June 7, 2011, indicating it is no longer open for new submissions under that specific posting.
Eligibility was broad and covered many types of U.S. and non-U.S. organizations, reflecting NIH’s typical openness to strong scientific applications regardless of institutional type, as long as applicant organizations meet NIH requirements. Eligible applicants included federal recognized Native American tribal governments; state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; public housing authorities/Indian housing authorities; nonprofits both with and without 501(c)(3) status; for-profit organizations (including small businesses and other for-profit entities); Native American tribal organizations that are not federally recognized tribal governments; and additional categories specifically named in the eligibility details. Those additional eligible applicants included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and foreign (non-U.S.) entities. This wide eligibility net aligned with the program’s collaborative intent, since meaningful team science in SCD often spans universities, medical centers, community organizations, and specialized research institutes, and can involve international collaborators where relevant expertise exists.
The sponsoring agency was the National Institutes of Health, with the program framed within NHLBI interests (as indicated in the title). The full announcement was made available through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PA-11-013.html. For access issues, the contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, which is the standard point of contact for technical problems reaching the posting rather than scientific or grants management questions.
Overall, this FOA can be understood as a targeted push to deepen and broaden the mechanistic understanding of SCD by funding interdisciplinary R01 projects that connect the dots between sickle cell pathology and systemic processes like inflammation, thrombosis, and vascular injury. The intent was to accelerate discovery of actionable mechanisms and potential intervention points that could complement or extend approaches focused strictly on red blood cell sickling, helping the field address the complex, multi-system nature of SCD complications.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "Sickle Cell Disease Inflammation, Thrombosis and Vascular Dysfunction, NHLBI (R01)" and it is associated with NIH funding opportunity announcement PA 11-013.
Which agency sponsored this announcement?
The sponsoring agency was the National Institutes of Health (NIH). The program was framed within National Heart, Lung, and Blood Institute (NHLBI) interests, as reflected in the title.
What type of grant mechanism was used?
The award mechanism was the NIH R01 research project grant, which typically supports hypothesis-driven, investigator-initiated research projects of significant scope.
What research focus did the FOA emphasize beyond classic sickling?
The FOA emphasized that sickle cell disease complications are influenced not only by the mechanical and rheological effects of sickled red blood cells, but also by broader biological processes. These included inflammation, coagulation and thrombosis, endothelial and vascular dysfunction, and immune-related pathways.
What was the central scientific idea behind the program?
The central idea was that pathways and regulatory mechanisms outside of red blood cell sickling itself may be just as important to sickle cell disease pathophysiology. The FOA encouraged discovering and defining these mechanisms to support better-targeted therapies and improved clinical outcomes.
What kinds of projects were encouraged?
The announcement encouraged genuinely collaborative, team-based projects rather than isolated single-discipline studies. It called for cross-disciplinary approaches designed to uncover mechanisms that might be missed when sickle cell disease is viewed primarily through hemoglobin polymerization and red cell deformation.
What disciplines and areas of expertise were highlighted as important for proposed teams?
The FOA highlighted collaboration between established sickle cell disease investigators and researchers from complementary fields, particularly biochemical, biophysical, and immunological disciplines. Examples of relevant areas included molecular and cellular signaling, vascular biology, platelet and coagulation biology, endothelial activation, immune cell behavior, inflammatory mediators, and biophysical interactions between blood cells and the vessel wall.
What was the long-term aim of funding this research?
The long-term aim was to enable better-targeted therapeutic strategies and improved clinical outcomes by accelerating discovery of actionable mechanisms and potential intervention points related to inflammation, thrombosis, and vascular injury in sickle cell disease.
What was the activity category for this program?
The activity category listed for this opportunity was Health.
What CFDA number was associated with this program?
The CFDA listing associated with the program was 93.839 (Blood Diseases and Resources Research).
Was cost sharing or matching required?
No cost sharing or matching was required, which is consistent with standard NIH research project grant practices.
When was the announcement posted?
The announcement was posted on October 26, 2010.
What was the closing date for submissions?
The original and current closing date listed was May 7, 2011.
Is this funding opportunity currently open?
No. The announcement was archived on June 7, 2011, indicating it is no longer open for new submissions under that specific posting.
Who was eligible to apply?
Eligibility was broad and included many U.S. and non-U.S. organization types, consistent with NIH's general approach to accepting strong scientific applications across institutional categories (as long as NIH requirements are met).
Which U.S. government entities were listed as eligible applicants?
Eligible applicants included federally recognized Native American tribal governments; state governments; county governments; city/township governments; special district governments; and independent school districts.
Were higher education institutions eligible?
Yes. Eligible applicants included public and state-controlled institutions of higher education as well as private institutions of higher education.
Were nonprofits eligible, including those without 501(c)(3) status?
Yes. Eligibility included nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status.
Could for-profit organizations apply?
Yes. For-profit organizations were eligible, including small businesses and other for-profit entities.
Were tribal organizations that are not federally recognized eligible?
Yes. Native American tribal organizations (other than federally recognized tribal governments) were listed as eligible applicants.
Were housing authorities included as eligible applicants?
Yes. Public housing authorities and Indian housing authorities were included in the eligibility list.
Were minority-serving institutions specifically named as eligible?
Yes. The eligibility details specifically named Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Were faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations were specifically named as eligible.
Were regional organizations and U.S. territories mentioned as eligible?
Yes. Regional organizations and U.S. territories or possessions were included in the additional eligibility categories.
Were foreign (non-U.S.) entities eligible to apply?
Yes. Foreign (non-U.S.) entities were explicitly included in the eligibility details.
Why did the FOA emphasize collaboration and team science?
The FOA reflected the view that meaningful progress in understanding sickle cell disease complications often requires cross-disciplinary expertise and can span universities, medical centers, community organizations, specialized research institutes, and international collaborators where relevant expertise exists.
Where could applicants find the full announcement?
The full announcement was available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-11-013.html.
Who was listed as the contact for access issues?
The contact listed for access issues was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV. This contact was described as a standard point of contact for technical problems reaching the posting.
Does the listed contact handle scientific or grants management questions?
Based on the information provided, the listed contact was for technical access issues related to the posting rather than scientific or grants management questions.
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