Opportunity Information: Apply for RFA DK 26 313
Apply for RFA DK 26 313
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Single Source for Continuation of the Accelerating Medicines Partnership (AMP) in Common Metabolic Diseases (CMD) Knowledge Portal (U01 Research Project (Cooperative Agreement) Clinical Trial not allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2026-02-06.
- Applicants must submit their applications by 2026-03-10. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others.
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Opportunity Summary:
This Notice of Funding Opportunity (NOFO), RFA-DK-26-313, is a one-time, non-competitive funding announcement from the National Institutes of Health (NIH) to support the continued operation and growth of the Accelerating Medicines Partnership (AMP) Common Metabolic Diseases (CMD) Knowledge Portal (KP). The mechanism is a U01 cooperative agreement (assistance listing/CFDA 93.847) and it specifically states that clinical trials are not allowed. The intent is straightforward: NIH plans to make a single award, and it is reserved exclusively for the current portal awardee, the Broad Institute, Inc., meaning no other institution is eligible to apply under this announcement.
The portal itself is positioned as the flagship, public-facing resource for the AMP CMD program, which is a multi-sector collaboration among NIH, pharmaceutical companies, and nonprofit organizations focused on improving how researchers identify and validate biological targets that could become biomarkers and/or drug targets for common metabolic diseases and related complications. In practical terms, the Knowledge Portal is not just a website; it is a continuously maintained and curated knowledge base that aggregates many different types of biomedical data and associated metadata so researchers can better understand biological heterogeneity across patients with CMDs. That emphasis on heterogeneity signals that the portal is meant to help users move beyond one-size-fits-all interpretations by enabling stratified analyses across traits, cohorts, and molecular layers.
Over the next five-year project period, the funded work is expected to keep pushing the portal forward rather than simply maintaining the status quo. The NOFO highlights several core expectations: expanding the breadth and depth of datasets and traits represented in the portal, bringing in additional data types, and rolling out additional analytical and visualization tools so users can do more meaningful exploration and interpretation directly through the platform. Another key expectation is to increase the portal's usefulness to a more diverse user base, which implies attention to usability, documentation, accessibility, and potentially outreach and training so that the resource serves not only specialized computational users but also broader biomedical and translational audiences. Finally, the awardee is expected to develop a framework for independent sustainability, suggesting NIH wants a credible plan for how the resource can remain viable long-term (for example, via governance, operations planning, partnerships, or other support models) beyond this funding window.
Although the opportunity is described as non-competitive in the sense that it is single-source and restricted to one eligible applicant, it is not an automatic renewal. The application will still undergo peer review, and the NOFO makes clear that funding depends on the application being judged meritorious; if reviewers do not view it as strong enough, it will not be funded. Operational details from the source notice include an expected number of awards of one, an award ceiling of $2,000,000, and an original application closing date of 2026-03-10, with the announcement created on 2026-02-06.
Frequently Asked Questions (FAQs)
What is the funding opportunity number and title?
The Notice of Funding Opportunity (NOFO) is RFA-DK-26-313. It is a one-time funding announcement from the National Institutes of Health (NIH) to support the continued operation and growth of the Accelerating Medicines Partnership (AMP) Common Metabolic Diseases (CMD) Knowledge Portal (KP).
Which agency is offering this grant?
This opportunity is offered by the National Institutes of Health (NIH).
What type of award mechanism will be used?
The award mechanism is a U01 cooperative agreement.
What is the Assistance Listing (CFDA) number for this opportunity?
The Assistance Listing/CFDA number is 93.847.
Is this opportunity competitive?
No. The NOFO describes it as a one-time, non-competitive announcement intended to make a single award.
How many awards does NIH expect to make?
NIH expects to make one award.
Who is eligible to apply under this NOFO?
Eligibility is restricted exclusively to the current portal awardee, the Broad Institute, Inc. No other institution is eligible to apply under this announcement.
Does "non-competitive" mean the award is automatic?
No. The application will still undergo peer review, and funding depends on the application being judged meritorious. If reviewers do not view the application as strong enough, it will not be funded.
Are clinical trials allowed under this NOFO?
No. The NOFO specifically states that clinical trials are not allowed.
What is being supported with this funding?
The funding is intended to support the continued operation and growth of the AMP CMD Knowledge Portal (KP), described as a continuously maintained and curated knowledge base and the flagship public-facing resource for the AMP CMD program.
What is the AMP Common Metabolic Diseases (CMD) program?
AMP CMD is described as a multi-sector collaboration among NIH, pharmaceutical companies, and nonprofit organizations focused on improving how researchers identify and validate biological targets that could become biomarkers and/or drug targets for common metabolic diseases and related complications.
What is the Knowledge Portal, in practical terms?
The Knowledge Portal is more than a website. It is a continuously maintained and curated knowledge base that aggregates multiple types of biomedical data and associated metadata to support research into common metabolic diseases.
What is a major scientific emphasis of the portal described in the NOFO?
A key emphasis is enabling researchers to better understand biological heterogeneity across patients with common metabolic diseases, including support for stratified analyses across traits, cohorts, and molecular layers.
What are the main expectations for the work over the project period?
The NOFO highlights expectations to keep advancing the portal, including expanding the breadth and depth of datasets and traits, incorporating additional data types, and rolling out additional analytical and visualization tools to enable more meaningful exploration and interpretation through the platform.
Is the goal to simply maintain the portal as-is?
No. The NOFO indicates the funded work is expected to push the portal forward rather than only maintain the status quo.
What kinds of enhancements are expected for data coverage?
The NOFO calls for expanding both the breadth and depth of datasets and traits represented in the portal and bringing in additional data types.
What kinds of enhancements are expected for user-facing functionality?
The NOFO expects the rollout of additional analytical and visualization tools so users can conduct more meaningful exploration and interpretation directly through the platform.
What does the NOFO say about serving a broader or more diverse user base?
The NOFO expects the awardee to increase the portal's usefulness to a more diverse user base, implying attention to usability, documentation, accessibility, and potentially outreach and training so the resource serves both specialized computational users and broader biomedical and translational audiences.
Is there an expectation related to long-term sustainability?
Yes. The awardee is expected to develop a framework for independent sustainability, with a credible plan for long-term viability beyond the funding window (for example, via governance, operations planning, partnerships, or other support models).
What is the project period described in the NOFO?
The NOFO describes expectations over a five-year project period.
What is the award ceiling for this opportunity?
The award ceiling is $2,000,000.
When is the application due?
The original application closing date is 2026-03-10.
When was the announcement created?
The announcement was created on 2026-02-06.
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