Opportunity Information: Apply for PA 16 092
Apply for PA 16 092
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Small Business Alzheimer's Disease Research (R41/R42)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866,.
- This funding opportunity was created on Feb 01, 2016 and posted on Feb 01, 2016.
- Applicants must submit their applications by Apr 05, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Opportunity Summary:
The Small Business Alzheimer's Disease Research (R41/R42) opportunity (Funding Opportunity Number PA 16-092) is a discretionary NIH grant program designed to stimulate Small Business Technology Transfer (STTR) projects focused specifically on Alzheimer's disease. In practical terms, the announcement is aimed at getting small businesses to work in formal partnership with a nonprofit research institution (such as a university or medical center) to move promising Alzheimer's-related science and technology toward real-world products, tools, or interventions. The funding is organized under the STTR mechanism, which is commonly used when the work requires both the commercialization drive of a company and the specialized research capabilities of an academic or clinical partner.
This announcement supports projects under the R41/R42 framework, which typically maps onto a phased development path. Phase I (R41) generally emphasizes proof-of-concept work, early feasibility, and risk reduction, while Phase II (R42) generally supports more advanced research and development steps that build on successful Phase I results and push the technology closer to practical deployment. For applicants, this structure is useful because it signals that reviewers will expect a clear, staged plan: first demonstrating that the approach is workable, then showing how it will be matured into something that can ultimately be tested, validated, manufactured, scaled, or otherwise prepared for broader use in the Alzheimer's field.
Eligibility is limited to small businesses, reflecting the program's intent to strengthen innovation and commercialization capacity in the private sector while still leveraging a research partner through the STTR model. The sponsoring agency is the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), identified in the source as HHS-NIH11. The activity category is Health, and the associated CFDA numbers are 93.866 (and 93.866 listed again in the source data), which indicates the NIH assistance listing category under which the program falls.
Key administrative details in the listing include an original and current closing date of April 5, 2019, with the opportunity first created and posted on February 1, 2016. The source data does not specify an award ceiling or expected number of awards, so applicants would typically need to consult the full announcement text, NIH budget guidelines for STTRs, and any institute-specific funding notes to understand typical funding ranges, budget caps (if any), and competitiveness. Overall, the central purpose of the opportunity is straightforward: to encourage and fund STTR grant applications from eligible small business concerns working on Alzheimer's disease-focused research and development with a trajectory toward impactful, usable outcomes.
FAQs: Small Business Alzheimer's Disease Research (R41/R42) - NIH STTR (PA 16-092)
What is this grant opportunity?
This is the Small Business Alzheimer's Disease Research (R41/R42) opportunity under NIH's Small Business Technology Transfer (STTR) program. It is a discretionary NIH grant program intended to stimulate STTR projects focused specifically on Alzheimer's disease.
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number provided is PA 16-092.
Who is the sponsoring agency?
The sponsoring agency is the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), identified as HHS-NIH11 in the source information.
What is the main purpose of the program?
The main purpose is to encourage and fund STTR applications that move promising Alzheimer's-related science and technology toward real-world products, tools, or interventions. The program is designed to support research and development with a trajectory toward usable outcomes in the Alzheimer's field.
What type of projects does this opportunity support?
The opportunity supports Alzheimer's disease-focused research and development projects conducted under the STTR model, where a small business works in a formal partnership with a nonprofit research institution (for example, a university or medical center). The intent is to combine a company's commercialization focus with the research capabilities of an academic or clinical partner.
What grant mechanism is used for this opportunity?
This opportunity uses the STTR mechanism and is organized under the R41/R42 framework.
What do R41 and R42 mean in practice?
R41 generally corresponds to Phase I and typically emphasizes proof-of-concept work, early feasibility, and risk reduction. R42 generally corresponds to Phase II and typically supports more advanced research and development steps that build on successful Phase I results and move the technology closer to practical deployment.
How should applicants think about the phased structure?
The phased structure signals that reviewers will expect a clear staged plan: first, demonstrate the approach is workable (Phase I), then show how it will be matured into something that can be tested, validated, manufactured, scaled, or otherwise prepared for broader use in Alzheimer's-related applications (Phase II).
Is this opportunity limited to Alzheimer's disease?
Yes. The announcement is specifically aimed at Alzheimer's disease-focused research and development.
Who is eligible to apply?
Eligibility is limited to small businesses, consistent with the program's goal of strengthening innovation and commercialization capacity in the private sector while leveraging a nonprofit research partner through the STTR model.
Does the program require a research partnership?
Yes. The STTR model is described as requiring the small business to work in formal partnership with a nonprofit research institution, such as a university or medical center.
What is the activity category for this opportunity?
The activity category is Health.
What CFDA (Assistance Listing) number is associated with this opportunity?
The associated CFDA number listed is 93.866 (it appears twice in the source data, but it is the same number).
When was this opportunity first posted?
The opportunity was first created and posted on February 1, 2016.
What was the closing date?
The original and current closing date listed is April 5, 2019.
Is the award ceiling listed?
No. The source information does not specify an award ceiling.
Does the listing state the expected number of awards?
No. The source information does not provide an expected number of awards.
Where would applicants typically look for budget ranges or caps?
Because the listing does not provide an award ceiling or expected number of awards, applicants would typically need to consult the full announcement text, NIH budget guidelines for STTR awards, and any institute-specific funding notes to understand typical funding ranges, budget caps (if any), and competitiveness.
What kind of outcomes is NIH trying to encourage through this program?
The central goal is to push Alzheimer's disease-related innovations toward practical, real-world deployment. The description emphasizes translation into products, tools, or interventions and highlights later-stage preparation steps such as testing, validation, manufacturing readiness, or scaling where appropriate.
Why does NIH use STTR for this topic area?
The STTR mechanism is commonly used when a project benefits from both the commercialization drive of a small business and the specialized research capabilities of an academic or clinical partner. For Alzheimer's disease R&D, this structure supports collaborative development that can move research toward practical use.
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