Opportunity Information: Apply for PA 16 091
Apply for PA 16 091
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Small Business Alzheimer's Disease Research (R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866,.
- This funding opportunity was created on Feb 01, 2016 and posted on Feb 01, 2016.
- Applicants must submit their applications by Apr 05, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Opportunity Summary:
The Small Business Alzheimer's Disease Research (R43/R44) opportunity (Funding Opportunity Number PA 16 091) is a National Institutes of Health (NIH) funding announcement under the U.S. Department of Health and Human Services (HHS) that supports small businesses pursuing research and development aimed at improving the understanding, detection, prevention, or treatment of Alzheimer's disease. It is structured as a discretionary, grant-based program using the SBIR mechanism, which is specifically designed to help small companies move promising scientific ideas toward practical, commercializable technologies. In plain terms, the government is looking to fund small businesses that can translate innovative research into tools, products, or platforms that could make a real impact on Alzheimer's disease.
This FOA uses the NIH SBIR phased award structure tied to the R43 and R44 activity codes. The R43 mechanism corresponds to SBIR Phase I, typically focused on establishing feasibility, proving a concept, or generating early technical data that shows a new approach has merit. The R44 mechanism corresponds to SBIR Phase II, generally intended to build on successful Phase I results by further developing, optimizing, and validating the technology, often moving it closer to readiness for clinical studies, regulatory planning, manufacturing considerations, or market entry. While the specific FOA text would define the exact expectations for each phase, the overall intent is to fund development-oriented research that goes beyond basic science and pushes toward a tangible innovation relevant to Alzheimer's disease.
Eligibility is limited to small businesses, reflecting the SBIR program's purpose of strengthening innovation within the U.S. small business sector while addressing high-priority public health needs. The funding activity category is Health, and the CFDA numbers associated with the opportunity are 93.866 (and also listed 93.866 again in the source data). The administering agency is identified as HHS-NIH11, indicating it is managed within NIH's organizational structure. Because this is a government grant opportunity, projects are expected to be proposed with clear technical milestones, a credible development plan, and an explanation of how the technology could advance progress in Alzheimer's disease, including the potential pathway to real-world use.
Key dates in the posting indicate the announcement was created and posted on February 1, 2016. The original and current closing date listed is April 5, 2019. The source data does not provide an award ceiling or expected number of awards, which means applicants would typically need to consult NIH policy and the full FOA text for budget limits, project period guidance, and any institute- or topic-specific constraints. Overall, the opportunity is best understood as NIH inviting SBIR proposals from qualified small businesses that are developing innovative technologies with the potential to meaningfully improve outcomes in Alzheimer's disease, from early feasibility work through more advanced development stages.
Frequently Asked Questions (FAQs)
What is this grant opportunity?
This is the Small Business Alzheimer's Disease Research (R43/R44) funding opportunity from the National Institutes of Health (NIH) under the U.S. Department of Health and Human Services (HHS). It supports small businesses doing research and development aimed at improving the understanding, detection, prevention, or treatment of Alzheimer's disease.
What is the Funding Opportunity Number (FON) for this announcement?
The Funding Opportunity Number is PA 16 091.
Which agency is offering and administering this opportunity?
The opportunity is offered by HHS through NIH. The administering agency is identified as HHS-NIH11, meaning it is managed within NIH's organizational structure.
What type of funding mechanism does this use?
It is a discretionary, grant-based program using the Small Business Innovation Research (SBIR) mechanism.
Who is eligible to apply?
Eligibility is limited to small businesses, consistent with the purpose of the SBIR program.
What does the government want to fund through this program?
The focus is on small businesses that can translate innovative research into practical, commercializable tools, products, or platforms that could make an impact on Alzheimer's disease. Projects should target improvements in understanding, detection, prevention, or treatment.
What do R43 and R44 mean in this announcement?
R43 corresponds to SBIR Phase I, and R44 corresponds to SBIR Phase II. These are the NIH SBIR phased activity codes used to support development from early feasibility through more advanced technology development.
What is the goal of SBIR Phase I (R43) under this opportunity?
Phase I (R43) is typically aimed at establishing feasibility, proving a concept, or generating early technical data to show that an approach has merit.
What is the goal of SBIR Phase II (R44) under this opportunity?
Phase II (R44) generally builds on successful Phase I results by further developing, optimizing, and validating the technology, often moving it closer to readiness for clinical studies, regulatory planning, manufacturing considerations, or market entry.
Is this opportunity intended for basic science or development-oriented work?
The overall intent is development-oriented research that goes beyond basic science and pushes toward a tangible innovation relevant to Alzheimer's disease.
What kinds of project elements are expected in an application?
Projects are expected to include clear technical milestones, a credible development plan, and an explanation of how the technology could advance progress in Alzheimer's disease, including the potential pathway to real-world use.
What is the program's main public health focus area?
The funding activity category is Health, with a focus on Alzheimer's disease.
What are the CFDA numbers associated with this opportunity?
The CFDA number listed is 93.866 (it is also repeated as 93.866 in the source data).
When was this funding announcement posted?
The posting date (created and posted) is February 1, 2016.
What is the application closing date?
The original and current closing date listed is April 5, 2019.
Is the award amount (ceiling) provided in the information given?
No. The source information does not provide an award ceiling.
Does the information provided say how many awards NIH expects to make?
No. The source information does not list an expected number of awards.
Where would an applicant typically look for budget limits or project period guidance?
Because the award ceiling and expected number of awards are not provided in the source data, applicants would typically need to consult NIH policy and the full FOA text for budget limits, project period guidance, and any institute- or topic-specific constraints.
Is this opportunity aimed at commercialization?
Yes. The SBIR mechanism is designed to help small companies move promising scientific ideas toward practical, commercializable technologies, and this opportunity emphasizes translating innovations into real-world use for Alzheimer's disease.
What is the overall takeaway of this opportunity based on the information provided?
NIH is inviting SBIR proposals from qualified small businesses developing innovative technologies with the potential to meaningfully improve outcomes in Alzheimer's disease, supporting work from early feasibility (Phase I/R43) through more advanced development (Phase II/R44).
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