Opportunity Information: Apply for RFA OD 12 004

  • The National Institutes of Health in the education environment food and nutrition health income security and social services sector is offering a public funding opportunity titled "Small Business Alzheimers Disease Research (STTRR41/R42)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.121 Oral Diseases and Disorders Research 93.136 Injury Prevention and Control Research and State and Community Based Programs 93.172 Human Genome Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.307 Minority Health and Health Disparities Research 93.350 National Center for Advancing Translational Sciences 93.351 Research Infrastructure Programs 93.361 Nursing Research 93.389 National Center for Research Resources 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research 93.879 Medical Library Assistance.
  • This funding opportunity was created on Feb 29, 2012 and posted on Feb 29, 2012.
  • Applicants must submit their applications by Apr 30, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
  • Eligible applicants include: Small businesses.
Apply for RFA OD 12 004

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Opportunity Summary:

The Small Business Alzheimers Disease Research opportunity (STTR R41/R42), released by the National Institutes of Health (NIH) under Funding Opportunity Number RFA-OD-12-004, is a discretionary grant program designed to stimulate research and development efforts led by eligible small business concerns working in Alzheimers disease. It was issued in the context of a broader federal push to accelerate Alzheimers research after the National Alzheimers Project Act was signed, and after the February 7, 2012 announcement by the Secretary of Health and Human Services that an additional $50 million would be directed immediately to boost Alzheimers research in fiscal year 2012. The announcement emphasizes that this increased federal investment is expected to support a wide spectrum of work, from foundational studies of Alzheimers biology and genetics to more applied translational and clinical projects focused on developing and testing potential therapies.

This funding opportunity specifically uses the Small Business Technology Transfer (STTR) mechanism, which generally supports projects where a small business collaborates formally with a nonprofit research institution, combining commercialization-oriented development with academic or institutional research strengths. The solicitation is tied to the STTR phased award structure referenced as R41/R42, which aligns with early feasibility and proof-of-concept work followed by additional development and validation activities. In practical terms, applicants would be expected to propose work that advances understanding of Alzheimers disease and/or moves a therapeutic, diagnostic, device, or enabling technology closer to real-world use, while fitting within the STTR framework that integrates small business innovation with research partner capabilities.

From an administrative standpoint, the program was posted and created on February 29, 2012, with an original and current closing date of April 30, 2012, and an archive date of May 31, 2012. The opportunity lists an estimated total funding amount of $2,000,000 and notes that there is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of the award. Eligibility is limited to small businesses, consistent with the STTR program rules. While the announcement is centered on Alzheimers disease, it is connected to a broad set of NIH activity areas, reflected in the many CFDA numbers included in the listing, spanning aging and neuroscience as well as complementary disciplines that can intersect with Alzheimers research such as genomics, mental health, translational sciences, minority health and disparities, and other biomedical domains.

The official agency point of contact for access or technical issues related to the announcement is the NIH Office of Extramural Research (OER) Webmaster, with the listing providing email contacts for difficulties accessing the announcement or problems linking to it. The primary public-facing reference for full details is the NIH grants guide page provided in the additional information link, which would contain the complete requirements, review criteria, and application instructions for small businesses seeking STTR support in Alzheimers-related research and development.

Frequently Asked Questions (FAQs)

What is the name of this funding opportunity?

The opportunity is titled the Small Business Alzheimers Disease Research opportunity (STTR R41/R42).

Who is offering this grant?

This opportunity was released by the National Institutes of Health (NIH).

What is the Funding Opportunity Number (FON)?

The Funding Opportunity Number is RFA-OD-12-004.

What type of grant program is this?

It is a discretionary grant program using the Small Business Technology Transfer (STTR) mechanism.

What does the STTR mechanism require in general?

STTR generally supports projects where an eligible small business collaborates formally with a nonprofit research institution, combining commercialization-oriented development with academic or institutional research strengths.

What do R41 and R42 refer to?

R41/R42 refers to the STTR phased award structure, aligning with early feasibility and proof-of-concept work (R41) followed by additional development and validation activities (R42).

What is the main research focus of this opportunity?

The opportunity is designed to stimulate research and development efforts led by eligible small business concerns working in Alzheimers disease.

What kinds of projects are appropriate under this solicitation?

Projects would be expected to advance understanding of Alzheimers disease and/or move a therapeutic, diagnostic, device, or enabling technology closer to real-world use, while fitting within the STTR framework that integrates small business innovation with research partner capabilities.

How does this opportunity fit into the broader federal Alzheimers research push described in the listing?

The solicitation was issued in the context of efforts to accelerate Alzheimers research after the National Alzheimers Project Act was signed, and after a February 7, 2012 announcement by the Secretary of Health and Human Services that an additional $50 million would be directed immediately to boost Alzheimers research in fiscal year 2012.

What range of Alzheimers research does the announcement say the increased investment may support?

The announcement states the increased federal investment is expected to support a wide spectrum of work, from foundational studies of Alzheimers biology and genetics to more applied translational and clinical projects focused on developing and testing potential therapies.

Who is eligible to apply?

Eligibility is limited to small businesses, consistent with STTR program rules.

Is cost sharing or matching required?

No. The opportunity states there is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of the award.

What is the estimated total funding amount?

The listing provides an estimated total funding amount of $2,000,000.

When was the opportunity posted/created?

The program was posted and created on February 29, 2012.

What is the closing date?

The original and current closing date listed is April 30, 2012.

When was the opportunity archived?

The archive date listed is May 31, 2012.

What NIH activity areas or subject areas does this opportunity connect to?

While centered on Alzheimers disease, the listing connects the opportunity to a broad set of NIH activity areas reflected in many CFDA numbers. These span aging and neuroscience and also include complementary disciplines that can intersect with Alzheimers research, such as genomics, mental health, translational sciences, minority health and disparities, and other biomedical domains.

Where can applicants find the full requirements and instructions?

The listing indicates the primary public-facing reference for full details is the NIH grants guide page provided in the additional information link, which would contain complete requirements, review criteria, and application instructions.

Who should be contacted for access or technical issues with the announcement?

The official agency point of contact for access or technical issues is the NIH Office of Extramural Research (OER) Webmaster. The listing provides email contacts for difficulties accessing the announcement or problems linking to it.

Does the provided information include detailed review criteria or application steps?

No. The description notes that the NIH grants guide page linked in the additional information would contain the complete requirements, review criteria, and application instructions.

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