Opportunity Information: Apply for PA 13 314

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Small Grants on Primary Immunodeficiency Diseases (R03)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
  • This funding opportunity was created on Aug 6, 2013 and posted on Aug 6, 2013.
  • Applicants must submit their applications by Sep 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $50,000.00 in funding.
  • Eligible applicants include: Private institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments State governments Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) County governments For profit organizations other than small businesses Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Small Grants on Primary Immunodeficiency Diseases (R03) opportunity (Funding Opportunity Number PA 13-314) is a National Institutes of Health discretionary grant program designed to fund focused, small-scale research projects in the area of primary immunodeficiency diseases. Its main goal is to encourage studies that improve how these disorders are detected and understood at a molecular level, and to accelerate progress toward new or improved therapies. The FOA highlights two especially relevant research directions: ex vivo work using human specimens (for example, studies that analyze patient-derived cells or tissues outside the body) and research using existing or newly developed animal models that better mirror specific immunodeficiency conditions. In addition, the announcement explicitly welcomes novel clinical strategies aimed at detection, identification of molecular causes, and innovative treatment approaches for primary immunodeficiency diseases.

This FOA uses the NIH R03 mechanism, which is specifically intended for smaller projects that can be completed in a relatively short timeframe with limited resources. The R03 format supports several common project types: pilot and feasibility studies that generate early evidence for a future larger project, secondary analyses of existing datasets, small self-contained research projects that answer a specific question without requiring large infrastructure, and efforts centered on developing new research methods or technologies. In practical terms, the program is structured to help investigators test new ideas, establish preliminary proof-of-concept, refine approaches, or generate critical data that can later underpin a more extensive NIH application. The FOA also makes clear that investigators who have not yet received independent NIH funding, or who have not received independent NIH funding specifically in this field, are encouraged to apply, which signals a strong interest in bringing new researchers and new perspectives into primary immunodeficiency research.

From an administrative standpoint, the program falls under the NIH health-related funding activity category and is associated with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research). The award ceiling listed is $50,000, and there is no cost-sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of receiving the award. The opportunity was posted and created on August 6, 2013, with an original and current closing date of September 7, 2016, and an archive date of October 8, 2016, indicating the announcement is no longer active but remains useful as a reference for the kinds of projects NIH sought to support under this mechanism.

Eligibility is broad across many U.S.-based organization types. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with 501(c)(3) status and those without it, in certain cases), for-profit organizations other than small businesses, small businesses, and a wide range of government entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly includes a range of institution types and community-based entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and certain regional organizations and eligible federal agencies. At the same time, it restricts applications from non-U.S. entities: foreign institutions and non-domestic components of U.S. organizations are not eligible to apply. However, the FOA allows foreign components as defined by the NIH Grants Policy Statement, meaning a U.S. applicant organization may still propose certain project elements that involve foreign collaboration or performance sites when justified and permitted under NIH rules.

Overall, this grant opportunity is best understood as a targeted, entry-friendly NIH mechanism to stimulate practical, hypothesis-driven or method-development work in primary immunodeficiency diseases, particularly studies grounded in human specimen analysis and animal modeling. It is structured to help researchers move quickly on well-defined questions, validate early ideas, and produce the kind of preliminary data or technical advances that can support larger translational or clinical trajectories in the immunodeficiency field.

FAQs: Small Grants on Primary Immunodeficiency Diseases (R03) - PA 13-314

What is the Small Grants on Primary Immunodeficiency Diseases (R03) opportunity?

It is a National Institutes of Health (NIH) discretionary grant program that uses the R03 mechanism to support focused, small-scale research projects related to primary immunodeficiency diseases.

What is the main goal of this funding opportunity?

The goal is to encourage studies that improve detection and molecular-level understanding of primary immunodeficiency disorders and to accelerate progress toward new or improved therapies.

What kinds of research directions does the FOA emphasize?

The announcement highlights two especially relevant directions: (1) ex vivo studies using human specimens (such as patient-derived cells or tissues studied outside the body) and (2) research using existing or newly developed animal models that better reflect specific immunodeficiency conditions.

Does the FOA support clinical strategies as well as basic research?

Yes. It explicitly welcomes novel clinical strategies focused on detection, identifying molecular causes, and innovative treatment approaches for primary immunodeficiency diseases.

What does the NIH R03 mechanism generally support?

The R03 mechanism is intended for smaller projects that can be completed in a relatively short timeframe with limited resources.

What project types are commonly supported under an R03?

The FOA describes several typical R03 project types: pilot and feasibility studies, secondary analyses of existing datasets, small self-contained research projects that address a specific question without requiring large infrastructure, and projects aimed at developing new research methods or technologies.

How is this opportunity intended to help investigators?

In practical terms, it is designed to help investigators test new ideas, establish preliminary proof-of-concept, refine approaches, or generate key data that can support a later, larger NIH application.

Are investigators without prior independent NIH funding encouraged to apply?

Yes. The FOA states that investigators who have not yet received independent NIH funding, or who have not received independent NIH funding specifically in this field, are encouraged to apply.

What is the Funding Opportunity Number (FON) for this announcement?

The Funding Opportunity Number is PA 13-314.

What is the maximum award amount listed for this opportunity?

The award ceiling listed is $50,000.

Is cost sharing or matching required?

No. The FOA indicates there is no cost-sharing or matching requirement.

Which CFDA numbers are associated with this program?

The opportunity is associated with CFDA 93.855 (Allergy and Infectious Diseases Research) and CFDA 93.856 (Microbiology and Infectious Diseases Research).

When was this funding opportunity posted and created?

It was posted and created on August 6, 2013.

What were the closing date and archive date?

The original and current closing date was September 7, 2016, and the archive date was October 8, 2016.

Is this FOA still active?

No. Based on the listed closing and archive dates, the announcement is no longer active, though it may remain useful as a reference for the types of projects NIH sought to support under this mechanism.

What types of U.S. organizations are eligible to apply?

Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations other than small businesses, small businesses, and many government entities (state, county, city/township, special district, independent school districts, and public housing authorities/Indian housing authorities).

Are minority-serving institutions and community-based organizations included in eligible applicants?

Yes. The FOA explicitly includes institution types such as HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and AANAPISIs, as well as faith-based or community-based organizations and certain regional organizations and eligible federal agencies.

Are foreign institutions eligible to apply?

No. Foreign institutions and non-domestic components of U.S. organizations are not eligible to apply.

Can the project include foreign components at all?

Yes, in a limited way. While non-U.S. entities cannot apply, the FOA allows foreign components as defined by the NIH Grants Policy Statement, meaning a U.S. applicant organization may propose certain project elements involving foreign collaboration or performance sites when justified and permitted under NIH rules.

What is the overall intent or “best fit” for projects under this FOA?

This opportunity is best understood as a targeted, entry-friendly NIH mechanism to stimulate practical, hypothesis-driven or method-development work in primary immunodeficiency diseases, particularly studies grounded in human specimen analysis and animal modeling, with the aim of generating early results that can support larger translational or clinical trajectories.

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