Opportunity Information: Apply for PAR 09 129
Apply for PAR 09 129
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Probe Production Centers Network (MLPCN) (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Mar 12, 2009 and posted on Mar 12, 2009.
- Applicants must submit their applications by Jan 4, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $25,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Small businesses For profit organizations other than small businesses Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Special district governments City or township governments County governments Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH funding opportunity PAR 09-129, titled "Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Probe Production Centers Network (MLPCN) (R03)," is designed to bring more investigators into the NIH Molecular Libraries Roadmap Initiative by supporting the development and submission of high quality HTS-ready assays that can be run at scale within the MLPCN. The central aim is to accelerate the discovery of new small-molecule chemical probes that researchers can use as practical tools to study biology, validate targets, and explore disease mechanisms. Rather than focusing on developing a therapeutic product directly, the program emphasizes creating reliable probes and openly sharing assay results so that both public and private sector scientists can build on them.
A key feature of this initiative is that awardees are meant to work in partnership with the MLPCN infrastructure. Investigators contribute biological insight and assay concepts, while the network provides access to industrial-style automated screening capacity and expertise needed to run large high throughput campaigns. The FOA is tied to three major components of the Molecular Libraries effort: (1) the MLPCN screening and probe development centers that can execute large-scale automated HTS, (2) the Molecular Libraries Small Molecule Repository (MLSMR), which houses diverse compound collections suitable for broad screening, and (3) PubChem BioAssay, the public database where biological activity data for screened compounds are deposited. In practice, this structure is meant to convert a promising assay into a screening campaign, then into validated hits and eventually into optimized chemical probes, while ensuring the resulting bioactivity data become a community resource.
The funding mechanism used is the NIH Small Research Grant (R03). Under the opportunity listing provided, the award ceiling is $25,000, and there is no cost sharing or matching requirement. The NIH notes that the number of assays selected is not fixed and will depend on scientific merit and on the capacity and resources available within the MLPCN at the time. However, the program’s stated operational target was to select and implement about 100 HTS assays per year beginning in 2008, signaling an intent to support a relatively high throughput pipeline of assay onboarding and screening to drive broad probe discovery efforts across many biological areas.
This is a discretionary grant opportunity in the health funding category (CFDA 93.310, Trans-NIH Research Support). The opportunity was posted on March 12, 2009, with an original and current closing date of January 4, 2012, and it was archived on February 4, 2012. The sponsoring agency is the National Institutes of Health.
Eligibility is broad and includes many organizational types: public and private institutions of higher education, state and local governments, tribal governments and organizations, nonprofits (including both 501(c)(3) and non-501(c)(3) entities), small businesses, and for-profit organizations other than small businesses. The eligibility language also explicitly includes a range of mission- or community-focused institutions and entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, U.S. territories or possessions, and even non-U.S. (foreign) organizations and regional organizations, along with eligible federal agencies. Taken together, the eligibility criteria reflect NIH’s interest in sourcing innovative assays from a wide cross-section of the research ecosystem, provided applicants have the interest and capability to collaborate effectively with the MLPCN screening and probe development pipeline.
Overall, the opportunity is best understood as an on-ramp for investigators who have a compelling biological target, pathway, or phenotype and can propose a robust assay suitable for automated high throughput screening, with the explicit goal of generating publicly useful chemical probes and openly accessible screening data through PubChem. The full announcement was hosted on the NIH Grants Guide site (as referenced in the additional information link), and technical access issues were directed to the NIH Office of Extramural Research webmaster contacts listed in the notice.
FAQs: NIH PAR 09-129 - Solicitation of Assays for High Throughput Screening (HTS) in the MLPCN (R03)
What is PAR 09-129?
PAR 09-129 is an NIH funding opportunity titled "Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Probe Production Centers Network (MLPCN) (R03)." It supports investigators who can develop and submit high-quality, HTS-ready biological assays that can be run at scale within the MLPCN.
What is the main purpose of this funding opportunity?
The main purpose is to accelerate discovery of new small-molecule chemical probes. These probes are intended as practical research tools to study biology, validate targets, and explore disease mechanisms, rather than to directly develop a therapeutic product.
What does the program expect applicants to provide?
Applicants are expected to contribute strong biological insight and a robust assay concept that is ready for high throughput screening. The emphasis is on assays that can be implemented in an automated, industrial-style screening environment.
What does "HTS-ready assay" mean in this context?
Within the scope described, an HTS-ready assay is one designed with the quality and robustness needed to run at large scale in an automated high throughput screening campaign managed through the MLPCN infrastructure.
What is the MLPCN and why is it part of this FOA?
The Molecular Libraries Probe Production Centers Network (MLPCN) provides the large-scale screening and probe development infrastructure that individual investigators typically do not have on their own. Awardees are intended to partner with MLPCN centers, combining investigator-driven assay ideas with network screening capacity and expertise.
What are the major components tied to the Molecular Libraries effort in this opportunity?
This opportunity is tied to three major components: (1) MLPCN screening and probe development centers that execute large-scale automated HTS, (2) the Molecular Libraries Small Molecule Repository (MLSMR), which houses diverse compound collections for screening, and (3) PubChem BioAssay, the public database where screening results are deposited.
Where do the screening results and bioactivity data go?
The opportunity states that biological activity data for screened compounds are deposited in PubChem BioAssay, making assay results openly accessible as a community resource.
Is the program focused on developing drugs or therapies?
No. The described emphasis is on discovering and validating chemical probes and on openly sharing assay results. The goal is to create reliable tools and data that others in the public and private sectors can build on.
What is the funding mechanism for PAR 09-129?
The funding mechanism is the NIH Small Research Grant (R03).
What is the award ceiling listed for this opportunity?
Under the listing provided, the award ceiling is $25,000.
Is cost sharing or matching required?
No. The opportunity specifies that there is no cost sharing or matching requirement.
How many awards or assays will NIH fund?
The number selected is not fixed and depends on scientific merit and the capacity and resources available within the MLPCN at the time.
Does the FOA indicate a target volume for assay selection?
Yes. The program described an operational target to select and implement about 100 HTS assays per year beginning in 2008, indicating an intent to support a high-throughput pipeline of assay onboarding and screening.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
What funding category and CFDA number are associated with this opportunity?
The opportunity is in the health funding category and is associated with CFDA 93.310 (Trans-NIH Research Support).
When was this opportunity posted, and what are the closing dates?
It was posted on March 12, 2009. The original and current closing date listed is January 4, 2012.
Is this funding opportunity still active?
No. It was archived on February 4, 2012.
What types of organizations are eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, state and local governments, tribal governments and organizations, nonprofits (both 501(c)(3) and non-501(c)(3)), small businesses, and for-profit organizations other than small businesses.
Are community-focused or mission-focused institutions explicitly included?
Yes. The eligibility language explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly included in the eligibility language provided.
Are non-U.S. (foreign) organizations eligible?
Yes. The eligibility description explicitly includes non-U.S. (foreign) organizations and regional organizations.
Are federal agencies eligible to apply?
Yes. The eligibility language includes eligible federal agencies.
What kind of project is the opportunity best suited for?
It is best suited for investigators with a compelling biological target, pathway, or phenotype who can propose a robust assay suitable for automated HTS, with the explicit goal of generating publicly useful chemical probes and openly accessible screening data through PubChem.
How does an assay move through the program pipeline as described?
The structure described is intended to take a promising assay into a screening campaign, then into validated hits, and eventually into optimized chemical probes, while ensuring the resulting bioactivity data become a community resource.
Where was the full announcement hosted?
The full announcement was hosted on the NIH Grants Guide site, as referenced by the additional information link in the notice.
Where were technical access issues directed?
Technical access issues were directed to the NIH Office of Extramural Research webmaster contacts listed in the notice.
Is this grant described as discretionary?
Yes. It is described as a discretionary grant opportunity.
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