Opportunity Information: Apply for RFA HD 10 026
Apply for RFA HD 10 026
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Specialized Centers in Research in Pediatric Developmental Pharmacology Program (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 16, 2010 and posted on Dec 16, 2010.
- Applicants must submit their applications by Mar 22, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Specialized Centers in Research in Pediatric Developmental Pharmacology Program (U54) funding opportunity (RFA-HD-10-026) is a National Institutes of Health initiative led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to support a small number of multidisciplinary research centers focused on pediatric developmental pharmacology. The main idea is to create well-organized “center” environments where basic scientists and clinical researchers work side by side to build strong translational research programs, meaning projects that deliberately connect laboratory discoveries to real-world pediatric testing, dosing, safety, and effectiveness questions. Rather than funding isolated individual projects, this program is structured to promote coordinated teamwork, shared expertise, and cross-disciplinary collaboration aimed at improving how medications are studied and used in infants, children, and adolescents, where developmental biology can strongly affect drug response.
A core purpose of the program is to strengthen high-quality translational research in high-priority areas of pediatric pharmacology, with an emphasis on developmental considerations that make children different from adults in absorption, distribution, metabolism, excretion, and pharmacodynamic response. These centers are expected to function as hubs that can tackle complex problems that often require combined skills in pediatrics, clinical pharmacology, developmental biology, genetics/genomics, bioinformatics, biostatistics, formulation science, and related fields. By concentrating resources and expertise, the centers are positioned to generate more reliable evidence that can inform pediatric dosing strategies, reduce adverse drug events, and support safer and more effective medication use for children at different stages of development.
Another major goal is workforce development. The centers are intended to serve as national resources for training and career development, helping to prepare new scientists for careers in pediatric translational research. In practice, that means the center structure should provide mentorship, research opportunities, and a professional pipeline for early-stage investigators who want to specialize in pediatric developmental pharmacology. The program’s emphasis on training recognizes that pediatric pharmacology research requires specialized knowledge and infrastructure, and that building a sustained cadre of investigators is necessary to keep progress moving forward in this field.
The funding opportunity also highlights a public-facing responsibility: community outreach and education. Center investigators are expected to communicate with broader audiences to increase awareness of why pediatric developmental pharmacology matters and what the implications of the research are for children’s health. This outreach component reflects a view that research centers should not only generate scientific findings but also help the public understand issues like pediatric drug safety, why pediatric studies can be ethically and scientifically complex, and how evidence-based pediatric dosing and labeling improvements can benefit families and healthcare systems.
Administratively, this opportunity uses the U54 mechanism, which is a cooperative agreement. That means NICHD is expected to have substantial programmatic involvement compared with a standard grant, typically through coordination, oversight, and collaborative planning with awardees. The opportunity was posted on December 16, 2010, with an application closing date of March 22, 2011, and an archive date of April 22, 2011. The estimated total funding amount listed is $3.5 million, with an award ceiling of $500,000. There is no cost-sharing or matching requirement. The CFDA number associated with the program is 93.865 (Child Health and Human Development Extramural Research).
Eligibility is broad and includes a range of organization types such as public and state-controlled institutions of higher education, private institutions of higher education, certain nonprofit organizations (including 501(c)(3) nonprofits and some non-501(c)(3) nonprofits), state governments, federally recognized tribal governments, other tribal organizations, and for-profit organizations other than small businesses. The eligibility section also explicitly references a variety of institution types often highlighted for federal opportunities, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, regional organizations, and U.S. territories or possessions. Overall, the program is designed to build a limited number of strong, collaborative centers that can move pediatric pharmacology forward through integrated research, training, and public engagement under NICHD’s cooperative agreement framework.
Frequently Asked Questions (FAQs)
What is the Specialized Centers in Research in Pediatric Developmental Pharmacology Program (U54)?
This is a National Institutes of Health (NIH) funding opportunity to support a small number of multidisciplinary research centers focused on pediatric developmental pharmacology. The program is designed to create well-organized "center" environments where basic scientists and clinical researchers work side by side in coordinated, translational research programs focused on how medicines work in infants, children, and adolescents.
Which NIH Institute leads this funding opportunity?
The opportunity is led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
What is the funding opportunity number for this program?
The funding opportunity is identified as RFA-HD-10-026.
What does "pediatric developmental pharmacology" mean in the context of this program?
In this program, pediatric developmental pharmacology refers to studying how developmental biology affects medication response in children. It emphasizes that infants, children, and adolescents can differ from adults in absorption, distribution, metabolism, excretion, and pharmacodynamic response, and that these differences matter for dosing, safety, and effectiveness.
What is the overall purpose of creating "center" environments rather than funding isolated projects?
The program is structured to promote coordinated teamwork, shared expertise, and cross-disciplinary collaboration. Rather than supporting standalone projects, it supports centers that can integrate multiple scientific and clinical capabilities to tackle complex pediatric pharmacology problems through deliberate translation from laboratory findings to real-world pediatric questions.
What types of research are these centers expected to support?
The centers are expected to strengthen high-quality translational research in high-priority areas of pediatric pharmacology, particularly research that connects laboratory discoveries to pediatric testing, dosing, safety, and effectiveness questions across different stages of child development.
What scientific and technical disciplines are emphasized for these multidisciplinary centers?
The opportunity emphasizes combined expertise that may include pediatrics, clinical pharmacology, developmental biology, genetics/genomics, bioinformatics, biostatistics, formulation science, and related fields. The goal is to concentrate resources and expertise to generate stronger evidence for pediatric medication use.
How does the program aim to improve pediatric medication use?
By supporting coordinated translational research, the centers are positioned to generate more reliable evidence that can inform pediatric dosing strategies, help reduce adverse drug events, and support safer and more effective medication use for children at different developmental stages.
Does this program include training and career development components?
Yes. Workforce development is a major goal. The centers are intended to serve as national resources for training and career development, creating mentorship and research opportunities and building a pipeline for early-stage investigators focused on pediatric translational research.
Who is the training pipeline intended to support?
The training emphasis is intended to help prepare new scientists for careers in pediatric translational research, especially those specializing in pediatric developmental pharmacology, where specialized knowledge and infrastructure are important.
Is community outreach and education part of the program expectations?
Yes. The opportunity highlights a public-facing responsibility for community outreach and education. Center investigators are expected to communicate with broader audiences to increase awareness of pediatric developmental pharmacology and its implications for children's health.
What kinds of topics are the centers expected to communicate about through outreach?
Based on the opportunity description, outreach should help the public understand why pediatric drug safety matters, why pediatric studies can be ethically and scientifically complex, and how evidence-based pediatric dosing and labeling improvements can benefit families and healthcare systems.
What grant mechanism is used for this opportunity?
This opportunity uses the U54 mechanism, which is a cooperative agreement.
What does it mean that this is a "cooperative agreement" (U54)?
A cooperative agreement means NICHD is expected to have substantial programmatic involvement compared with a standard grant. This typically includes coordination, oversight, and collaborative planning with awardees.
When was this funding opportunity posted?
The opportunity was posted on December 16, 2010.
What was the application closing date?
The application closing date was March 22, 2011.
When was the opportunity archived?
The archive date listed is April 22, 2011.
How much total funding is estimated for this program?
The estimated total funding amount listed for the program is $3.5 million.
What is the award ceiling?
The award ceiling listed is $500,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost-sharing or matching requirement.
What is the CFDA number associated with this program?
The CFDA number associated with the program is 93.865, labeled as Child Health and Human Development Extramural Research.
What types of organizations are eligible to apply?
Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, certain nonprofit organizations (including 501(c)(3) and some non-501(c)(3) nonprofits), state governments, federally recognized tribal governments, other tribal organizations, and for-profit organizations other than small businesses.
Are minority-serving institutions and certain designated institution types included in eligibility?
Yes. The eligibility description explicitly references institution types commonly highlighted in federal opportunities, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, regional organizations, and U.S. territories or possessions.
How many centers is the program intended to support?
The opportunity describes supporting a small number of centers and notes that it is designed to build a limited number of strong, collaborative centers.
What makes this program different from a typical single-investigator grant?
It is designed around a coordinated center structure (not isolated projects), emphasizes multidisciplinary collaboration and shared resources, includes explicit workforce development and outreach expectations, and operates under a U54 cooperative agreement with substantial NICHD involvement.
What is the main translational focus of the centers supported under this program?
The translational focus is to deliberately connect laboratory discoveries with practical pediatric questions, including pediatric testing, dosing, safety, and effectiveness, taking into account developmental differences that can affect medication response.
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