Opportunity Information: Apply for RFA HD 16 014
Apply for RFA HD 16 014
- The HHS-NIH11 in the health, income security and social services sector is offering a public funding opportunity titled "Specialized Centers in Research in Pediatric Developmental Pharmacology (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865,.
- This funding opportunity was created on Dec 11, 2015 and posted on Dec 11, 2015.
- Applicants must submit their applications by Feb 18, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Specialized Centers in Research in Pediatric Developmental Pharmacology (U54) opportunity, listed as RFA HD 16 014, is a re-competition of the Research in Pediatric Developmental Pharmacology Centers Program (RPDP) run by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) within NIH (agency listed as HHS-NIH11). It uses a U54 cooperative agreement mechanism, which generally means NICHD expects to have an active partnership role with awardees rather than acting only as a passive funder. The overall aim is to support a small number of multidisciplinary research Centers focused on pediatric developmental pharmacology, with a strong emphasis on translational research that connects basic science discoveries to clinical applications in children.
At its core, this FOA is designed to create Center environments where basic and clinical scientists can work side by side to build high-quality translational programs in pediatric developmental pharmacology. In practical terms, the Centers are meant to be hubs that bring together expertise across disciplines to address how medicines work in children as they grow and develop, recognizing that pediatric drug response is shaped by developmental biology and that children are not simply "small adults" in terms of dosing, metabolism, safety, and effectiveness. By funding Centers rather than isolated projects, NICHD is signaling that it values coordinated programs with shared infrastructure, collaboration, and a pipeline from mechanistic research through clinical investigation.
Beyond research, the FOA explicitly highlights workforce development and the strengthening of the field. Each Center is expected to serve as a national resource for educating and training new scientists who want to build careers in translational research in high-priority areas of pediatric developmental pharmacology. This training focus suggests the program is interested in cultivating expertise that can sustain and expand the national capacity to conduct rigorous pediatric pharmacology studies, including the ability to move discoveries toward real-world pediatric care.
The announcement also places weight on community outreach and public education. Center investigators are expected to engage in efforts that increase awareness of the research, explain why it matters, and communicate implications to the general public. This component points to a broader mission: not only generating evidence, but also improving understanding among patients, families, and communities about pediatric medication research, its goals, and its potential benefits and limitations.
Administratively, the opportunity falls under the broader federal activity category of Health, Income Security and Social Services and is associated with CFDA numbers 93.865. The posted and creation dates are both December 11, 2015, and the closing date listed is February 18, 2016 (original and current closing dates match). The funding details indicate an award ceiling of $500,000 and an expectation of about 4 awards, reflecting the intent to fund only a limited number of Centers with substantial, program-level responsibilities rather than many smaller, independent awards.
Eligibility is broad and includes many types of organizations that can support complex research and training programs. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations both with and without 501(c)(3) status (as long as they are not institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities as described in the FOA’s additional eligibility language. This wide eligibility range is consistent with NIH Center programs, which often support university-based medical research while also allowing participation by other qualified institutions capable of conducting pediatric translational pharmacology research and associated training and outreach.
Overall, the opportunity is best understood as NICHD’s effort to maintain and refresh a national network of pediatric developmental pharmacology Centers that integrate multidisciplinary translational research, build the next generation of investigators, and communicate the value and impact of pediatric pharmacology research to the public.
Frequently Asked Questions (FAQs)
What is the Specialized Centers in Research in Pediatric Developmental Pharmacology (U54) funding opportunity?
This opportunity (RFA HD 16 014) supports Specialized Centers in Research in Pediatric Developmental Pharmacology using the NIH U54 cooperative agreement mechanism. It is a re-competition of the Research in Pediatric Developmental Pharmacology Centers Program (RPDP) administered by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) within NIH (agency listed as HHS-NIH11).
What does it mean that this is a re-competition of the RPDP Centers Program?
It means NICHD is renewing and refreshing an existing Center-based program (RPDP) by running a new competition for awards under the same broad program concept: a small network of multidisciplinary Centers focused on pediatric developmental pharmacology with strong translational emphasis.
What is the main purpose or overall aim of this FOA?
The FOA aims to support a small number of multidisciplinary research Centers focused on pediatric developmental pharmacology, emphasizing translational research that connects basic science discoveries to clinical applications in children.
What kind of research emphasis is expected (basic, clinical, or translational)?
The announcement emphasizes translational research. The Centers are intended to connect mechanistic/basic science discoveries to clinical investigation and ultimately to applications relevant to pediatric care.
Why does the FOA stress that children are not simply "small adults"?
The opportunity is centered on the idea that pediatric drug response is shaped by developmental biology. As children grow and develop, differences in dosing, metabolism, safety, and effectiveness can be substantial, so pediatric pharmacology requires dedicated study rather than adult-to-child extrapolation.
What is the award mechanism and why does it matter?
The mechanism is a U54 cooperative agreement. In general, a cooperative agreement means NICHD expects to play an active partnership role with awardees, rather than serving only as a passive funder.
What is meant by "Center" funding rather than funding individual projects?
The FOA signals support for coordinated, multidisciplinary programs with shared infrastructure and collaboration, creating hub-like environments where basic and clinical scientists can work side by side and maintain a pipeline from discovery to clinical investigation.
What non-research activities are expected of funded Centers?
In addition to research, the FOA highlights (1) workforce development through education and training of new scientists and (2) community outreach and public education to increase awareness and understanding of the research and its implications.
What is the training and workforce development expectation for Centers?
Each Center is expected to function as a national resource for educating and training new scientists pursuing careers in translational research in high-priority areas of pediatric developmental pharmacology. The intent is to strengthen and sustain national capacity in this field.
What does the FOA say about outreach and public education?
Center investigators are expected to engage in outreach and public education efforts that increase awareness of the research, explain why it matters, and communicate implications to the general public, including patients, families, and communities.
Which NIH Institute is running this program?
The program is run by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which is part of the National Institutes of Health (NIH). The agency is listed as HHS-NIH11.
How many awards are expected?
The funding details indicate an expectation of about 4 awards, reflecting an intent to fund a limited number of Centers with substantial program-level responsibilities.
What is the maximum award amount (award ceiling)?
The posted funding details list an award ceiling of $500,000.
What are the key dates listed for this opportunity?
The posted and creation dates are both December 11, 2015. The closing date listed is February 18, 2016, and the original and current closing dates match.
What federal activity category is associated with this opportunity?
The opportunity is listed under the broader federal activity category of Health, Income Security and Social Services.
What CFDA number is associated with this program?
The opportunity is associated with CFDA 93.865.
Who is eligible to apply?
Eligibility is broad and includes multiple organization types that can support complex research, training, and outreach activities, including government entities, academic institutions, tribal governments and organizations, nonprofits, and for-profits.
Are state and local government entities eligible?
Yes. Eligible applicants include state governments, county governments, city or township governments, and special district governments.
Are public education entities eligible?
Yes. Independent school districts are listed as eligible applicants.
Are colleges and universities eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education as well as private institutions of higher education.
Are tribal governments or tribal organizations eligible?
Yes. Federally recognized Native American tribal governments and other tribal organizations are included in the eligibility list.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations with and without 501(c)(3) status are listed as eligible, as long as they are not institutions of higher education within those nonprofit categories.
Are for-profit organizations eligible?
Yes. Both small businesses and for-profit organizations other than small businesses are listed as eligible.
Does this FOA allow other entity types beyond the ones listed?
Yes. The eligibility description includes "other entities as described in the FOA's additional eligibility language," indicating there may be additional eligible entity types defined within the full FOA.
What kind of Center environment is NICHD trying to create?
The FOA is designed to foster environments where basic and clinical scientists collaborate closely, supported by shared infrastructure and coordinated programs that can move from mechanistic research toward clinical applications in children.
What is the broader goal of maintaining a network of Centers?
The opportunity is positioned as NICHD's effort to maintain and refresh a national network of pediatric developmental pharmacology Centers that (1) integrate multidisciplinary translational research, (2) build the next generation of investigators, and (3) communicate the value and impact of pediatric pharmacology research to the public.
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