Opportunity Information: Apply for RFA EY 12 001
Apply for RFA EY 12 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Stem Cell Approaches to Developing New Therapies for Ocular Diseases (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.867 Vision Research.
- This funding opportunity was created on Feb 7, 2012 and posted on Feb 7, 2012.
- Applicants must submit their applications by Jul 2, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) State governments County governments Special district governments For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Independent school districts Private institutions of higher education City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The funding opportunity titled "Stem Cell Approaches to Developing New Therapies for Ocular Diseases (R01)" (Funding Opportunity Number RFA-EY-12-001) is a discretionary research grant issued by the National Institutes of Health (NIH) under the vision research program (CFDA 93.867). Its central goal is to stimulate research that uses human stem cells as a foundation for developing new therapeutic approaches for eye diseases and disorders, particularly by creating methods to generate replacement ocular cells and by improving or inventing transplantation techniques that could restore or preserve vision.
A key scientific emphasis of this announcement is on moving stem-cell-based concepts toward practical therapeutic strategies for ocular conditions. Applications are expected to focus on human stem cells and may address the biological and technical steps needed to produce clinically relevant cell types found in the eye. This includes work aimed at understanding and controlling the mechanisms that drive stem cell differentiation into specialized ocular lineages. In other words, the FOA supports studies that either refine the recipe for turning human stem cells into specific eye cell types or clarify the underlying developmental signals and pathways that make such differentiation reliable, efficient, and reproducible.
In addition to generating replacement cells, the opportunity explicitly highlights transplantation techniques as an area of interest. That focus signals interest not only in producing the right cells, but also in solving the practical hurdles that determine whether a cell therapy can work in living tissue, such as delivery methods, survival and integration of transplanted cells, and approaches that would make these procedures feasible for treating ocular diseases. The overall theme is translationally oriented: projects should be positioned to advance stem-cell-derived ocular cell replacement and transplantation toward eventual therapeutic use, even if the proposed work is still preclinical.
This FOA uses the NIH R01 mechanism, meaning it is intended for hypothesis-driven, investigator-initiated research projects with clearly defined aims. The award ceiling is listed as $250,000, and the estimated total funding associated with the announcement is $2,000,000. There is no cost sharing or matching requirement, which generally means applicants are not expected to provide non-federal funds as a condition of the award. The opportunity was posted on February 7, 2012, with an original and current closing date of July 2, 2012, and it was archived on August 2, 2012, indicating it is no longer accepting applications now but remains a useful reference for the type of work NIH sought to support in this area.
Eligibility is broad and includes many categories of domestic U.S. organizations, such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city or township, special district governments), as well as independent school districts and public housing authorities/Indian housing authorities. It also includes Native American tribal governments and tribal organizations. The announcement further clarifies that a range of special-designation institutions and community-focused entities are eligible, including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
Notably, the FOA allows participation from non-U.S. entities as well. Foreign institutions are eligible to apply, non-domestic components of U.S. organizations may be included, and foreign components are allowed as defined in the NIH Grants Policy Statement. This design supports international or cross-border collaborations when they add unique capabilities, expertise, or resources relevant to human stem cell research and ocular therapy development.
For applicants or readers seeking the complete official announcement details, NIH provided an additional information link to the archived FOA page: http://grants.nih.gov/grants/guide/rfa-files/RFA-EY-12-001.html. For technical issues accessing or linking to the announcement, NIH lists the Office of Extramural Research (OER) Webmaster contact at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The funding opportunity is titled "Stem Cell Approaches to Developing New Therapies for Ocular Diseases (R01)" and the Funding Opportunity Number (FON) is RFA-EY-12-001.
Which agency is offering this funding opportunity?
This is a discretionary research grant offered by the National Institutes of Health (NIH).
What NIH program area does this opportunity fall under?
The opportunity is issued under NIH's vision research program (CFDA 93.867).
What is the central goal of this funding opportunity?
The central goal is to stimulate research that uses human stem cells as a foundation for developing new therapeutic approaches for eye diseases and disorders, particularly by generating replacement ocular cells and improving or inventing transplantation techniques that could restore or preserve vision.
What research theme is NIH emphasizing in this FOA?
A key emphasis is moving stem-cell-based concepts toward practical therapeutic strategies for ocular conditions, with projects positioned to advance stem-cell-derived ocular cell replacement and transplantation toward eventual therapeutic use (even if the work is still preclinical).
Does the FOA require the use of human stem cells?
Applications are expected to focus on human stem cells.
What types of scientific questions or activities are encouraged related to generating ocular cells?
The FOA supports work to produce clinically relevant cell types found in the eye and studies aimed at understanding and controlling the mechanisms that drive stem cell differentiation into specialized ocular lineages. This includes refining methods ("recipes") for differentiation and clarifying the underlying developmental signals and pathways so differentiation is reliable, efficient, and reproducible.
Is transplantation research explicitly within scope?
Yes. The opportunity explicitly highlights transplantation techniques as an area of interest, including practical hurdles such as delivery methods, survival and integration of transplanted cells, and approaches that could make procedures feasible for treating ocular diseases.
Is this funding opportunity focused on translational research?
Yes. The overall theme is translationally oriented, supporting research intended to move stem-cell-derived ocular cell replacement and transplantation toward therapeutic use.
What grant mechanism is used for this opportunity?
This FOA uses the NIH R01 mechanism, intended for hypothesis-driven, investigator-initiated research projects with clearly defined aims.
What is the award ceiling listed in the announcement?
The award ceiling is listed as $250,000.
How much total funding is estimated for this FOA?
The estimated total funding associated with the announcement is $2,000,000.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement, meaning applicants are generally not expected to provide non-federal funds as a condition of the award.
When was the opportunity posted and when did it close?
The opportunity was posted on February 7, 2012. The original and current closing date listed is July 2, 2012.
Is this FOA still accepting applications?
No. It was archived on August 2, 2012, indicating it is no longer accepting applications, though it remains available as an archived reference.
Who is eligible to apply within the United States?
Eligibility is broad for domestic U.S. organizations and includes public and state-controlled institutions of higher education; private institutions of higher education; nonprofits (including 501(c)(3) and certain non-501(c)(3) entities); for-profit organizations (including small businesses and other for-profits); and government entities (state, county, city or township, and special district governments). Independent school districts and public housing authorities/Indian housing authorities are also eligible.
Are tribal governments and tribal organizations eligible?
Yes. Native American tribal governments and tribal organizations are included as eligible applicants.
Are institutions with special designations (like HBCUs and HSIs) eligible?
Yes. The FOA explicitly notes eligibility for Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs), among others.
Are faith-based, community-based, or regional organizations eligible?
Yes. The announcement includes faith-based or community-based organizations and regional organizations among eligible entities.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed as eligible.
Can foreign (non-U.S.) organizations apply?
Yes. Foreign institutions are eligible to apply.
Can a U.S. organization include non-U.S. components in the project?
Yes. Non-domestic components of U.S. organizations may be included, and foreign components are allowed as defined in the NIH Grants Policy Statement.
Why does the FOA allow foreign components and foreign applicants?
The design supports international or cross-border collaborations when they add unique capabilities, expertise, or resources relevant to human stem cell research and ocular therapy development.
Where can applicants find the full official FOA details?
The archived FOA page is available at: http://grants.nih.gov/grants/guide/rfa-files/RFA-EY-12-001.html
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues, NIH lists the Office of Extramural Research (OER) Webmaster at: FBOWebmaster@OD.NIH.GOV
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