Opportunity Information: Apply for PA 12 233
Apply for PA 12 233
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Stem Cells and Alcohol induced Tissue Injuries (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Jul 10, 2012 and posted on Jul 10, 2012.
- Applicants must submit their applications by Sep 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Private institutions of higher education Native American tribal governments (Federally recognized) County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities State governments Small businesses City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity titled "Stem Cells and Alcohol induced Tissue Injuries (R01)" (Funding Opportunity Number PA-12-233) was a National Institutes of Health (NIH) research project grant announcement designed to support in-depth, hypothesis-driven studies on how stem cells contribute to tissue damage and tissue repair in the context of alcohol exposure. The central idea behind the FOA is that alcohol misuse is not limited to a single organ system; instead, it can trigger or worsen injury across many tissues. Because stem and progenitor cells are key players in maintaining tissue integrity, regenerating damaged structures, and sometimes giving rise to tumors under harmful conditions, the NIH sought applications that would clarify the ways alcohol and its metabolic byproducts alter stem-cell behavior and thereby shape disease onset, progression, and recovery.
From a scientific focus standpoint, the FOA emphasized both human and non-human stem cells, which signals interest in a broad range of experimental approaches, including human cell-based systems, animal models, and comparative mechanistic studies. Alcohol abuse is strongly associated with conditions such as alcoholic liver disease (ALD), pancreatitis, cardiovascular disease, neurological injury, endocrine dysfunction, osteoporosis, immune dysfunction, and multiple cancers. The announcement aimed to encourage research that connects alcohol-related pathology to stem cell and progenitor cell biology within these organ systems. This can include studying how alcohol affects stem cell survival, self-renewal, differentiation, migration, and functional integration into tissues, as well as how alcohol-induced inflammation, oxidative stress, and metabolic disruption reshape the stem-cell niche (the local microenvironment that regulates stem cell fate).
A major theme of the opportunity was understanding alcohol metabolism as a driver of stem-cell-related injury and repair outcomes. Alcohol is metabolized into biologically reactive intermediates (such as acetaldehyde) and can shift redox balance and generate oxidative stress; these processes may damage DNA, interfere with normal epigenetic regulation, and alter signaling pathways that control regeneration. The FOA highlighted interest in how these metabolic and molecular events influence stem cells directly and indirectly through the tissue environment. In practical terms, responsive projects could explore, for example, whether alcohol exposure changes stem cell lineage decisions in the liver, impairs neural stem cell contributions to brain repair, disrupts bone remodeling by altering mesenchymal stem cell function, or weakens immune recovery by affecting hematopoietic progenitors.
Another explicit priority was alcohol-related cancers, particularly the role of stem cells in cancer initiation, promotion, and recurrence. Many cancers are thought to involve cancer stem-like cells or progenitor populations that acquire mutations and become dysregulated. The FOA therefore encouraged studies that address how alcohol exposure and alcohol metabolism might increase malignant transformation risk, promote expansion of precancerous stem/progenitor populations, or alter tumor microenvironments in ways that favor cancer stem cell persistence and therapy resistance. This focus aligns with the broader public health concern that alcohol consumption is a known risk factor for several cancers and may interact with tissue regeneration pathways in ways that elevate that risk.
Administratively, this was a discretionary NIH grant using the R01 mechanism, meaning it supported substantial, multi-year research projects typically led by a principal investigator with a defined research plan and rigorous aims. The CFDA listing associated with this opportunity was 93.273 (Alcohol Research Programs). There was no cost-sharing or matching requirement, which is typical for many NIH research grants and reduces barriers for applicants who may not have access to large non-federal matching funds.
Eligibility was broad and included many types of U.S. organizations: public and private institutions of higher education, nonprofits with or without 501(c)(3) status, for-profit organizations (other than small businesses), small businesses, independent school districts, and various government entities (city/township, county, state, special district governments), as well as public housing authorities/Indian housing authorities. The FOA also explicitly allowed applications from tribal governments and tribal organizations, and it expanded eligibility to include a wide range of mission-driven institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs). Faith-based and community-based organizations were also listed as eligible where appropriate. Notably, foreign institutions and non-U.S. components of U.S. organizations were eligible to apply, and foreign components (as defined by NIH policy) were allowed, reflecting NIH interest in leveraging international expertise and resources when scientifically justified.
In terms of timing, the opportunity was posted on July 10, 2012, and ultimately closed on September 7, 2015, with an archive date of October 8, 2015. While it is no longer active, it represents a clear snapshot of NIH priorities during that period: moving beyond descriptive links between alcohol and organ damage toward mechanistic, regenerative, and stem-cell-centered explanations that could ultimately inform prevention strategies and therapeutic approaches. The full archived announcement was made available through the NIH grants guide (http://grants.nih.gov/grants/guide/pa-files/PA-12-233.html), and the NIH Office of Extramural Research (OER) webmaster contact was provided for access or linking issues (FBOWebmaster@OD.NIH.GOV).
FAQs: Stem Cells and Alcohol induced Tissue Injuries (R01) (PA-12-233)
What is the title of this grant opportunity?
The opportunity is titled "Stem Cells and Alcohol induced Tissue Injuries (R01)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-12-233.
Which agency offered this funding opportunity?
This was an opportunity from the National Institutes of Health (NIH).
What type of grant mechanism did this opportunity use?
It used the R01 mechanism, described as an NIH research project grant intended to support substantial, multi-year, hypothesis-driven research projects led by a principal investigator with a defined research plan and rigorous aims.
What was the overall purpose of this FOA?
The FOA was designed to support in-depth, hypothesis-driven studies on how stem cells contribute to tissue damage and tissue repair in the context of alcohol exposure, including how alcohol and its metabolic byproducts alter stem-cell behavior and influence disease onset, progression, and recovery.
Why did NIH emphasize stem cells in alcohol-related tissue injury?
The FOA stated that alcohol misuse can affect many organ systems, and that stem and progenitor cells are central to maintaining tissue integrity, regenerating damaged structures, and, under harmful conditions, may contribute to tumor formation. NIH sought research clarifying how alcohol-related processes change stem-cell behavior and outcomes.
Was this opportunity focused on a single organ system?
No. A central idea in the FOA was that alcohol misuse is not limited to one organ system and can trigger or worsen injury across multiple tissues.
What kinds of stem cells were included in the scientific scope?
The FOA emphasized both human and non-human stem cells, signaling interest in a broad range of experimental approaches, including human cell-based systems, animal models, and comparative mechanistic studies.
What alcohol-related conditions and organ systems were specifically mentioned?
The FOA noted strong associations between alcohol abuse and conditions such as alcoholic liver disease (ALD), pancreatitis, cardiovascular disease, neurological injury, endocrine dysfunction, osteoporosis, immune dysfunction, and multiple cancers.
What stem cell behaviors and processes were highlighted as potential research topics?
The announcement highlighted interest in how alcohol affects stem cell and progenitor cell biology, including potential effects on survival, self-renewal, differentiation, migration, and functional integration into tissues.
Did the FOA address the stem-cell niche or microenvironment?
Yes. The FOA specifically mentioned interest in how alcohol-induced inflammation, oxidative stress, and metabolic disruption reshape the stem-cell niche (the local microenvironment that regulates stem cell fate).
How did alcohol metabolism factor into the FOA priorities?
A major theme was understanding alcohol metabolism as a driver of stem-cell-related injury and repair outcomes. The FOA discussed alcohol being metabolized into biologically reactive intermediates (such as acetaldehyde), shifting redox balance, generating oxidative stress, and potentially causing DNA damage, interfering with epigenetic regulation, and altering signaling pathways involved in regeneration.
What kinds of mechanistic questions did the FOA encourage applicants to study?
Based on examples in the FOA, responsive projects could explore whether alcohol exposure changes stem cell lineage decisions in the liver, impairs neural stem cell contributions to brain repair, disrupts bone remodeling by altering mesenchymal stem cell function, or weakens immune recovery by affecting hematopoietic progenitors.
Did this opportunity include a cancer-related focus?
Yes. An explicit priority was alcohol-related cancers, including the role of stem cells in cancer initiation, promotion, and recurrence.
How did the FOA connect alcohol exposure to cancer stem-like cells or tumor behavior?
The FOA encouraged studies on how alcohol exposure and alcohol metabolism might increase malignant transformation risk, promote expansion of precancerous stem/progenitor populations, or alter tumor microenvironments in ways that favor cancer stem cell persistence and therapy resistance.
Was cost sharing or matching required?
No. The FOA stated there was no cost-sharing or matching requirement.
What was the CFDA listing associated with this opportunity?
The CFDA listing associated with this opportunity was 93.273 (Alcohol Research Programs).
Who was eligible to apply?
Eligibility was broad and included many types of U.S. organizations: public and private institutions of higher education, nonprofits with or without 501(c)(3) status, for-profit organizations (other than small businesses), small businesses, independent school districts, and various government entities (including city/township, county, state, and special district governments), as well as public housing authorities/Indian housing authorities.
Were tribal governments and tribal organizations eligible?
Yes. The FOA explicitly allowed applications from tribal governments and tribal organizations.
Did the FOA specifically include eligibility for minority-serving institutions?
Yes. The FOA listed eligibility for a range of mission-driven institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Were faith-based and community-based organizations eligible?
Yes. The FOA stated that faith-based and community-based organizations were eligible where appropriate.
Could foreign institutions apply to this FOA?
Yes. The FOA stated that foreign institutions and non-U.S. components of U.S. organizations were eligible to apply.
Were foreign components allowed under NIH policy?
Yes. The FOA stated that foreign components (as defined by NIH policy) were allowed.
When was the opportunity posted?
The FOA was posted on July 10, 2012.
When did the opportunity close?
The FOA closed on September 7, 2015.
What was the archive date?
The archive date was October 8, 2015.
Is this funding opportunity still active?
No. Based on the provided dates, the FOA is no longer active and is available as an archived announcement.
Where can the full archived announcement be found?
The archived announcement was made available through the NIH grants guide at: http://grants.nih.gov/grants/guide/pa-files/PA-12-233.html
Who was listed as a contact for access or linking issues?
The NIH Office of Extramural Research (OER) webmaster contact was provided for access or linking issues: FBOWebmaster@OD.NIH.GOV.
What does this FOA represent in terms of NIH priorities during the period it was active?
The FOA was described as a snapshot of NIH priorities at the time: moving beyond descriptive links between alcohol and organ damage toward mechanistic, regenerative, and stem-cell-centered explanations that could ultimately inform prevention strategies and therapeutic approaches.
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