Opportunity Information: Apply for RFA AI 11 036
Apply for RFA AI 11 036
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Strategies for the Protection of Pregnant Women and Infants Against Infectious Diseases (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jul 22, 2011 and posted on May 27, 2011.
- Applicants must submit their applications by Oct 13, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,900,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- The number of recipients for this funding is limited to 8 candidate(s).
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education County governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses State governments City or township governments Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
The grant opportunity titled "Strategies for the Protection of Pregnant Women and Infants Against Infectious Diseases (R01)" (Funding Opportunity Number RFA-AI-11-036) is a discretionary NIH research grant designed to push forward new, creative, and mechanistic studies on infectious pathogens that threaten pregnancy and early life. The central focus is on understanding how specific pathogens disrupt placental function and compromise fetal well-being, because the placenta is both a critical lifeline between mother and fetus and a key site where infections can cause outsized harm. By emphasizing mechanistic work, this opportunity is aimed at generating the kind of cause-and-effect biological insight that can directly inform future preventions and treatments, ultimately reducing infection-related pregnancy loss as well as infant illness and death.
This funding announcement sits within the broader health research mission of the NIH and aligns strongly with infectious disease and maternal-child health priorities. The associated CFDA program areas listed include 93.855 (Allergy and Infectious Diseases Research), 93.856 (Microbiology and Infectious Diseases Research), and 93.865 (Child Health and Human Development Extramural Research), which signals a clear expectation that projects may span immunology, microbiology, pathogenesis, and pregnancy/early-life biology. In practical terms, the FOA is looking for projects that go beyond descriptive correlations and instead clarify the biological mechanisms through which pathogens affect the placenta, the developing fetus, and newborn outcomes, with the long-term intent that these insights will support the development of interventions (such as therapeutics, vaccines, diagnostics, or other preventive strategies) and reduce the overall burden of adverse pregnancy and infant outcomes linked to infection.
The award mechanism is an R01, meaning it is intended to support substantial, hypothesis-driven research projects that can sustain a coherent program of investigation. NIH anticipated making about 8 awards under this announcement, with an estimated total funding amount of about $2.9 million. The award ceiling is listed as $350,000, which indicates an upper limit on award size under the terms of this solicitation. There is no cost-sharing or matching requirement, so applicants are not expected to provide non-federal matching funds as a condition of the award.
Eligibility is broad and inclusive, covering a wide range of organization types across academia, government, nonprofit, and industry. Eligible applicants include public and private institutions of higher education, nonprofits with or without 501(c)(3) status (with the noted exception framework common to NIH listings), for-profit organizations (other than small businesses) as well as small businesses, and multiple levels of government including state governments, county governments, city or township governments, special district governments, and independent school districts. The announcement also explicitly includes Native American tribal governments (both federally recognized and other than federally recognized) and tribal organizations, along with tribally controlled colleges and universities. Additional eligible categories include Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities, faith-based or community-based organizations, and other entities referenced in the eligibility clarification. Importantly, the FOA allows participation by non-U.S. entities (foreign organizations), regional organizations, and U.S. territory or possession applicants, and it also allows foreign components of U.S. organizations. This structure reflects an understanding that pregnancy-related infections and the pathogens that drive them are global problems and that key expertise, cohorts, model systems, or pathogen strains may exist outside the United States.
From an administrative standpoint, the FOA was posted on May 27, 2011, with the original and current closing date both listed as October 13, 2011, and an archive date of November 13, 2011. While these dates indicate the specific competition window for that cycle, the content provides a useful snapshot of NIH priorities and the types of studies NIH has actively encouraged in this area. The primary agency listed is the National Institutes of Health, and the full announcement was made available through the NIH grants website at the provided link.
For applicants or readers who need help accessing the official announcement or encounter technical issues, the contact point provided is the NIH Office of Extramural Research (OER) Webmaster, reachable at FBOWebmaster@OD.NIH.GOV. This contact is geared toward resolving access and linking problems rather than scientific program questions.
Overall, the opportunity is best understood as a targeted call for rigorous, mechanistically grounded research that explains how infectious agents harm placental function and fetal outcomes, with an explicit translational motivation: building the knowledge base needed to design interventions that protect pregnant women and infants and reduce the severe consequences of infection during pregnancy and early life.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Strategies for the Protection of Pregnant Women and Infants Against Infectious Diseases (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-AI-11-036.
Who is the primary agency offering this funding?
The primary agency listed is the National Institutes of Health (NIH).
What type of award mechanism is used?
The award mechanism is an R01, which is intended to support substantial, hypothesis-driven research projects that sustain a coherent program of investigation.
What is the main scientific focus of this FOA?
This FOA focuses on new, creative, mechanistic studies of infectious pathogens that threaten pregnancy and early life, with a central emphasis on understanding how specific pathogens disrupt placental function and compromise fetal well-being.
Why does the FOA emphasize the placenta?
The placenta is described as both a critical lifeline between mother and fetus and a key site where infections can cause outsized harm. The FOA prioritizes work that explains cause-and-effect mechanisms of how pathogens affect placental function and downstream fetal and newborn outcomes.
What does "mechanistic" mean in the context of this announcement?
Within this announcement, mechanistic research means studies that move beyond descriptive correlations and instead clarify the biological mechanisms (cause-and-effect pathways) through which pathogens affect the placenta, the developing fetus, and newborn outcomes.
What kinds of outcomes is the FOA ultimately trying to reduce?
The long-term intent is to reduce infection-related pregnancy loss as well as infant illness and death linked to infections during pregnancy and early life.
How is this FOA connected to translational impact (prevention and treatment)?
The FOA frames mechanistic insight as a foundation for future interventions, noting that the knowledge generated can inform the development of therapeutics, vaccines, diagnostics, and other preventive strategies.
What NIH program areas (CFDA) are associated with this opportunity?
The CFDA program areas listed are 93.855 (Allergy and Infectious Diseases Research), 93.856 (Microbiology and Infectious Diseases Research), and 93.865 (Child Health and Human Development Extramural Research).
What research areas does the CFDA listing suggest may be relevant?
Based on the CFDA areas provided, the FOA signals relevance to immunology, microbiology, infectious disease pathogenesis, and pregnancy/early-life biology.
How many awards did NIH anticipate making?
NIH anticipated making about 8 awards under this announcement.
What was the estimated total funding amount for the competition?
The estimated total funding amount was about $2.9 million.
Is there an award ceiling (maximum award size) stated?
Yes. The award ceiling is listed as $350,000, indicating an upper limit on award size under the terms of this solicitation.
Is cost sharing or matching required?
No. There is no cost-sharing or matching requirement; applicants are not expected to provide non-federal matching funds as a condition of the award.
What kinds of organizations are eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofits with or without 501(c)(3) status (within the noted exception framework common to NIH listings); for-profit organizations (other than small businesses) and small businesses; and multiple levels of government (state, county, city or township, special district governments, and independent school districts).
Are tribal governments and tribal organizations eligible?
Yes. The FOA explicitly includes Native American tribal governments (federally recognized and other than federally recognized), tribal organizations, and tribally controlled colleges and universities.
Are minority-serving institutions mentioned as eligible?
Yes. The eligibility list explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, and Historically Black Colleges and Universities (HBCUs).
Are faith-based or community-based organizations eligible?
Yes. The announcement explicitly includes faith-based or community-based organizations among eligible applicants.
Can foreign (non-U.S.) organizations apply?
Yes. The FOA allows participation by non-U.S. entities (foreign organizations), regional organizations, and U.S. territory or possession applicants.
Are foreign components of U.S. organizations allowed?
Yes. The FOA allows foreign components of U.S. organizations.
What is the posting date for this FOA?
The FOA was posted on May 27, 2011.
What is the closing date listed for this opportunity?
The original and current closing date are both listed as October 13, 2011.
What is the archive date?
The archive date is listed as November 13, 2011.
Does the FOA information suggest it was a time-limited competition window?
Yes. The listed posting, closing, and archive dates indicate a specific competition window for that cycle.
Where was the full announcement made available?
The full announcement was made available through the NIH grants website at the provided link referenced in the opportunity description.
Who should be contacted for technical issues accessing the official announcement?
The contact point provided for access and linking problems is the NIH Office of Extramural Research (OER) Webmaster.
What is the email address for the NIH OER Webmaster listed in the opportunity?
The email address is FBOWebmaster@OD.NIH.GOV.
Is the listed contact intended for scientific or program questions?
No. The provided contact is geared toward resolving access and linking problems rather than scientific program questions.
In one sentence, what is the overall intent of the FOA?
It is a targeted call for rigorous, mechanistically grounded research explaining how infectious agents harm placental function and fetal outcomes, with a translational motivation to enable interventions that protect pregnant women and infants and reduce severe infection-related consequences.
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