Opportunity Information: Apply for PAS 10 246
Apply for PAS 10 246
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Strategies for Treatment of Young Adults with Alcohol Use Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Aug 4, 2010 and posted on Aug 4, 2010.
- Applicants must submit their applications by Sep 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Private institutions of higher education Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH, through the National Institute on Alcohol Abuse and Alcoholism (NIAAA), released this Funding Opportunity Announcement (PAS 10-246) to push forward research on how to better treat alcohol use disorders in young adults ages 18 to 25. The central idea is that this age group has the highest rates of heavy or high-risk drinking compared to any other age bracket, and alcohol use disorders (including alcohol dependence) also peak during these years. At the same time, the period from 18 to 25 is marked by major developmental transitions, so the FOA emphasizes that treatment approaches may need to be tailored to the realities of young adult life rather than simply borrowed from adolescent or older adult treatment models. NIAAA highlights that, despite the size and seriousness of the problem, interventions for young adults have been relatively understudied, leaving clear gaps in the evidence base.
The research focus is practical and treatment-centered: applicants are expected to address challenges such as how to successfully engage young adults in treatment in the first place, which treatment approaches are most effective for this population, and how to sustain positive outcomes after treatment ends. In other words, the announcement is not only about reducing drinking during an active intervention, but also about understanding longer-term maintenance of treatment gains, which is often where relapse risk and drop-off in support become most pronounced for young adults.
This particular opportunity uses the NIH R01 mechanism, meaning it is intended for full-scale, hypothesis-driven research projects rather than small pilots. NIAAA notes that this R01 FOA runs alongside two companion announcements with the same scientific scope but different grant mechanisms: PAS 10-247 (R03), which typically supports smaller, more limited projects, and PAS 10-248 (R21), which commonly supports exploratory or early-stage research. Together, the three FOAs are meant to cover a range of project sizes and maturity levels while keeping the scientific goals consistent.
Funding is described as competitive and dependent on application quality rather than guaranteed. For fiscal year 2011, NIAAA set aside an estimated total of $1.5 million in total costs, and anticipated up to six total awards across this FOA and its companion announcements combined. The final number of awards and total dollars would depend on how many strong applications were received, along with the proposed budgets and project durations.
Administrative details indicate this is a discretionary grant opportunity in the health area, under CFDA 93.273 (Alcohol Research Programs), and it does not require cost sharing or matching. The FOA was posted August 4, 2010, with an original and current closing date of September 7, 2013, and an archive date of October 8, 2013, meaning it is no longer active today but remains relevant as a description of NIAAA priorities during that period.
Eligibility is broad and includes many types of organizations that can carry out health research, such as public and private institutions of higher education, nonprofits with or without 501(c)(3) status, for-profit organizations (including small businesses), state governments, tribal governments and tribal organizations, U.S. territories or possessions, and a variety of mission-focused institutions (for example, HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities). It also indicates that faith-based and community-based organizations, eligible federal agencies, and even non-U.S. entities (foreign organizations) may apply, reflecting NIH’s wide eligibility framework for research participation when the scientific work is strong and feasible.
In plain terms, this grant opportunity was designed to build a stronger, more targeted treatment science for young adults with alcohol use disorders by funding rigorous research that improves engagement, identifies effective interventions, and extends the durability of treatment benefits beyond the end of care.
Frequently Asked Questions (FAQs): NIH/NIAAA PAS 10-246 (R01) - Young Adult Alcohol Use Disorder Treatment Research
What is PAS 10-246?
PAS 10-246 is a Funding Opportunity Announcement (FOA) released by the National Institutes of Health (NIH) through the National Institute on Alcohol Abuse and Alcoholism (NIAAA). It was created to advance research on how to better treat alcohol use disorders in young adults.
What age group is the FOA focused on?
The FOA is specifically focused on young adults ages 18 to 25.
Why does NIAAA focus on ages 18 to 25 for alcohol treatment research?
NIAAA highlights that young adults (18 to 25) have the highest rates of heavy or high-risk drinking compared to other age brackets, and that alcohol use disorders (including alcohol dependence) peak during these years. This period also involves major developmental transitions, which can affect treatment needs and engagement.
What is the main purpose of this funding opportunity?
The purpose is to build stronger, more targeted treatment science for young adults with alcohol use disorders by funding rigorous research that improves treatment engagement, identifies effective interventions, and supports longer-term maintenance of treatment gains after care ends.
What kinds of research topics does the FOA emphasize?
The FOA emphasizes practical, treatment-centered research topics, including:
- How to successfully engage young adults in treatment
- Which treatment approaches are most effective for young adults
- How to sustain positive outcomes after treatment ends (maintenance of treatment gains)
Is the FOA only about reducing drinking during treatment?
No. The FOA explicitly emphasizes long-term outcomes, including how to maintain treatment gains after an intervention ends, when relapse risk and drop-off in support can be especially pronounced for young adults.
Does the FOA suggest that young adult treatments should differ from adolescent or older adult models?
Yes. NIAAA notes that ages 18 to 25 involve major developmental transitions and implies that treatment approaches may need to be tailored to young adult realities rather than simply borrowed from adolescent or older adult treatment models.
What grant mechanism does PAS 10-246 use?
PAS 10-246 uses the NIH R01 grant mechanism, which is intended for full-scale, hypothesis-driven research projects rather than small pilot studies.
Are there related or companion funding opportunities tied to the same scientific scope?
Yes. NIAAA released two companion announcements with the same scientific scope but different grant mechanisms:
- PAS 10-247 (R03), typically for smaller, more limited projects
- PAS 10-248 (R21), commonly for exploratory or early-stage research
How competitive is the funding under this opportunity?
Funding is described as competitive and dependent on application quality. Awards are not guaranteed.
How much funding was available?
For fiscal year 2011, NIAAA set aside an estimated total of $1.5 million in total costs. This total applied across this FOA and its companion announcements combined.
How many awards were anticipated?
NIAAA anticipated up to six total awards across PAS 10-246 and its companion announcements combined. The final number depended on the quality of applications received, proposed budgets, and project durations.
Is cost sharing or matching required?
No. The opportunity states that it does not require cost sharing or matching.
What type of grant program is this categorized under?
It is described as a discretionary grant opportunity in the health area under CFDA 93.273 (Alcohol Research Programs).
When was this FOA posted?
The FOA was posted on August 4, 2010.
What were the closing date and archive date?
The original and current closing date was September 7, 2013, and the archive date was October 8, 2013.
Is PAS 10-246 still active?
No. Based on the listed closing and archive dates, this FOA is no longer active today. It remains relevant as a record of NIAAA priorities during that period.
Who is eligible to apply?
Eligibility is broad and includes many organization types capable of conducting health research, including:
- Public and private institutions of higher education
- Nonprofits (with or without 501(c)(3) status)
- For-profit organizations (including small businesses)
- State governments
- Tribal governments and tribal organizations
- U.S. territories or possessions
- Mission-focused institutions such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities
- Faith-based and community-based organizations
- Eligible federal agencies
- Non-U.S. entities (foreign organizations)
Does this FOA allow foreign organizations to apply?
Yes. The eligibility description indicates that non-U.S. entities (foreign organizations) may apply.
What is the central problem this FOA is trying to address?
NIAAA identifies a major public health problem (high-risk drinking and peak alcohol use disorder rates among 18 to 25-year-olds) and notes that interventions for young adults have been relatively understudied, leaving gaps in the evidence base. This FOA aims to help close those gaps through rigorous treatment research.
What kind of project scale is NIAAA looking for under PAS 10-246?
Because the mechanism is R01, the FOA is intended for full-scale, hypothesis-driven research rather than small or purely preliminary efforts.
What factors influence the final number of awards and total funding actually granted?
The FOA states that the final number of awards and total dollars depend on the number of strong applications received, as well as the budgets and project durations proposed by applicants.
What is the plain-language takeaway for applicants or interested readers?
This opportunity was designed to strengthen the science of treating alcohol use disorders in young adults by supporting research that improves getting young adults into treatment, determines what works best for them, and helps ensure benefits last beyond the end of care.
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Previous opportunity: Strategies for Treatment of Young Adults with Alcohol Use Disorders (R03)
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