Strengthening Local Capacity to Provide Sustainable HIV Related Care and Treatment Services in South Africa under the President s Emergency Plan for AIDS Relief (PEPFAR) | Apply Online

Opportunity Summary:

The grant opportunity titled "Strengthening Local Capacity to Provide Sustainable HIV Related Care and Treatment Services in South Africa under the President s Emergency Plan for AIDS Relief (PEPFAR)" is a Centers for Disease Control and Prevention (CDC) funding announcement designed to reinforce South Africa s existing health system so it can deliver durable, locally led HIV services over the long term. The program focuses on strengthening service delivery across the full continuum of care, including community-based services, primary health care facilities, and tertiary care settings. A central feature of the opportunity is that supported activities are meant to be carried out in collaboration with, and under the direction of, the South African National Department of Health (NDOH) and its provincial, district, and local designees, reflecting an emphasis on alignment with government priorities, systems, and leadership rather than stand-alone parallel programming.

The overall intent is to advance PEPFAR s core objectives in South Africa by improving health outcomes and the performance of the HIV response system. The announcement highlights four broad goals: reducing illness and death associated with HIV/AIDS and tuberculosis (TB); strengthening the effectiveness of the HIV response system at district, provincial, and national levels; preventing new HIV infections; and working directly with district Departments of Health and their designated counterparts to identify, shape, and implement policies and programs that improve the district response to HIV prevention, care, and treatment. In practice, this framing signals that awardees are expected to provide technical assistance that helps health authorities plan, manage, and improve services, and to do so in a way that builds lasting institutional capacity within the public health sector.

This Funding Opportunity Announcement (FOA) explicitly builds on prior PEPFAR support provided through HHS/CDC programming related to HIV clinical services and antiretroviral treatment (ART). Rather than starting a new initiative from scratch, it is structured to maintain continuity of technical support while also improving and expanding comprehensive HIV services for both current and future clients. The emphasis on comprehensive programming indicates support that spans prevention, clinical care, and treatment, with ART scale-up and quality improvement as key components, alongside the broader service elements needed to sustain patient outcomes such as effective linkage to care, retention, adherence support, and integration with TB-related services.

A notable feature of this opportunity is its focus on local ownership and indigenous leadership. Eligibility is restricted to indigenous South African organizations only, meaning the CDC intended the funding to flow directly to in-country institutions positioned to continue the work within South Africa s health system context. This approach aligns with the broader PEPFAR direction of building country capacity and supporting transitions toward sustainable, locally managed HIV programs. The award mechanism is a cooperative agreement, which typically indicates substantial involvement by the funding agency during implementation, such as collaboration on technical direction, monitoring expectations, and alignment with evolving public health guidance and national strategies.

From an administrative and funding standpoint, the opportunity is categorized as discretionary funding in the health area under CFDA number 93.067 (Global AIDS). The CDC anticipated making about five awards, with an estimated total funding level of 75,000,000. There was no cost sharing or matching requirement. The funding opportunity number is CDC RFA GH11 1109, and the posting timeline shows it was posted on Feb 11, 2011, with an original and final closing date of Apr 12, 2011, and an archive date of May 12, 2011, indicating the opportunity is historical rather than currently open.

For organizations that applied at the time, the practical takeaway would have been that proposals needed to demonstrate strong coordination with the NDOH and district health structures, a clear plan for strengthening systems across levels of care, and the ability to deliver high-quality technical assistance that improves HIV and TB outcomes while contributing to prevention and overall response effectiveness. Because the FOA centers on sustainability and system strengthening, competitive applications would likely have emphasized capacity building, policy and program support at district level, and approaches that embed improvements into routine public-sector service delivery rather than relying on external, temporary project structures.

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