“Strengthening the Evidence Base and Capacity for Implementing HIV Prevention and Care and Treatment Programs in the Republic of South Africa under the United States Presidents Emergency Plan for AIDS Relief (PEPFAR)”. | Apply Online

Opportunity Summary:

This grant opportunity is a continuation cooperative agreement from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), under the Center for Global Health. It is titled "Strengthening the Evidence Base and Capacity for Implementing HIV Prevention and Care and Treatment Programs in the Republic of South Africa under the United States Presidents Emergency Plan for AIDS Relief (PEPFAR)." In practical terms, the focus is on improving how HIV programs in South Africa are planned, carried out, and evaluated by building stronger local and national capacity and by generating better evidence to guide implementation. The opportunity sits within PEPFAR, the long-running U.S. initiative that supports HIV prevention, care, and treatment services globally, and it reflects the CDC role in public health technical leadership, surveillance, monitoring and evaluation, and program improvement.

The mechanism is a cooperative agreement, which usually means the CDC expects to be substantially involved in the work beyond simply providing funds. Recipients typically collaborate closely with CDC staff on technical direction, aligning activities with PEPFAR priorities, using recommended public health approaches, and meeting reporting and performance requirements. The opportunity is categorized as continuation funding, indicating it is meant to extend or continue existing work rather than launch an entirely new standalone project. That also suggests applicants are expected to have an established presence, relationships, and operational experience relevant to HIV programming and public health systems in South Africa.

The core purpose described is to strengthen the evidence base and capacity for implementing HIV prevention and care and treatment programs. "Evidence base" generally points to generating, analyzing, and using data that can answer real program questions: what is working, for whom, where, and why; what gaps remain; and which strategies are most efficient and equitable. This often includes monitoring and evaluation systems, routine data quality improvement, surveillance support, program evaluations, and applied research or implementation science that helps translate proven interventions into consistent real-world outcomes. "Capacity" generally points to building the skills, systems, and institutional capabilities of South African entities and partners so that programs can be managed, improved, and sustained, including strengthening workforce competencies, management systems, data systems, and the ability to use evidence for decision-making.

Because the activity category is listed as Health and the CFDA number is 93.067 (a CDC global health funding line), the funded work typically aligns with public health functions such as strategic information, epidemiology, surveillance, laboratory systems support, quality improvement, and technical assistance for prevention and clinical service delivery programs. Within PEPFAR HIV programming, this can encompass prevention approaches (such as testing strategies, linkage to prevention services, and targeted prevention for populations at higher risk), care and treatment improvements (supporting linkage to care, retention, adherence, viral load monitoring, and program quality), and cross-cutting systems that make those services more effective (data use, supply chain coordination interfaces, workforce development, and partner coordination). The title makes clear that the geographic focus is the Republic of South Africa.

From an administrative standpoint, the opportunity number is CDC RFA GH14-140304CONT17, with a creation date of September 22, 2016, and an original closing date of November 22, 2016. The listing indicates an expectation of about 10 awards. The award ceiling is shown as 0, which in many government postings is a data-entry convention meaning the ceiling is not specified in the synopsis rather than literally indicating no funding; the actual funding level and budget expectations are often detailed in the full funding announcement or in continuation guidance provided to eligible recipients. The instrument type being a cooperative agreement signals that budgets, work plans, and performance measures are typically negotiated and refined with CDC involvement, and that recipients are expected to follow PEPFAR reporting structures and CDC technical guidance.

Eligibility is labeled broadly as "Others (see text field entitled Additional Information on Eligibility for clarification)." In many CDC continuation opportunities, this phrasing is used when eligibility is limited to a defined set of organizations, often current recipients or specific partners with existing awards, rather than open competition to all entities. Without the full eligibility text, the safest interpretation is that eligibility rules are specialized and should be checked in the full announcement or related continuation documentation.

Overall, this opportunity is best understood as CDC-supported, PEPFAR-aligned continuation funding aimed at improving HIV program impact in South Africa by strengthening the systems and expertise needed to implement prevention and treatment programs effectively and by producing and using high-quality evidence to guide decisions. It emphasizes measurable public health outcomes, strong monitoring and evaluation, and close collaboration with CDC as part of the cooperative agreement structure.

Browse more opportunities from the same agency: Department of Health and Human Services, Centers for Disease Control - CGH

Browse more opportunities from the same category: Health

Next opportunity: Technical Assistance and Support for the Development and Implementation of Key Aspects of HIV/AIDS Care and Support Services in South Africa under the President’s Emergency Plan for AIDS Relief (PEPFAR).

Previous opportunity: Strengthening the South African National Department of Health (NDOH) to implement and evaluate evidence-based public health program, surveillance and disease control efforts under the President’s Emergency Plan for AIDS Relief (PEPFAR)

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