Stress Management Interventions to Reduce Risk of Coronary Artery Disease (R01) | Apply Online

Opportunity Summary:

The National Institutes of Health (NIH) announced this R01 grant opportunity, titled "Stress Management Interventions to Reduce Risk of Coronary Artery Disease," to support research that tests whether stress management programs can meaningfully improve heart-related outcomes in people who already have confirmed coronary artery disease (CAD). The central idea behind the announcement is that mental stress is believed to contribute to major adverse cardiac events (MACE) through specific biological and behavioral pathways, and NIH is looking for studies that can rigorously evaluate whether reducing or managing stress can interrupt those pathways in measurable ways.

A key feature of this opportunity is its emphasis on intermediate, mechanistic outcomes rather than only long-term clinical endpoints. Applicants are encouraged to evaluate stress management interventions using outcomes that sit between mental stress and hard cardiac events, such as subclinical measures of atherosclerosis (for example, indicators of early plaque burden or progression), measures of cardiac function or endothelial function, and stress-provoked physiological responses. The announcement specifically highlights outcomes like cardiovascular reactivity and neurohumoral responses measured during a provocative mental stress test, reflecting interest in how the body responds under acute psychological stress and whether an intervention can blunt harmful responses (such as exaggerated blood pressure or heart rate changes, stress hormone surges, or autonomic dysregulation). In other words, the research is expected to help clarify not just whether stress management "helps," but how it may help, by mapping effects onto plausible pathways linking stress to cardiac risk.

The ultimate goal is translation to clinical practice. NIH signals that, if a stress management approach can be shown to slow CAD progression or reduce MACE, the field should be positioned to bring effective interventions into routine cardiac care. That translation focus implies interest in interventions that could be implemented in real-world clinical settings, potentially including behavioral, psychological, or structured stress reduction programs, so long as the application can credibly evaluate efficacy using the kinds of mechanistic measures described.

From an administrative standpoint, this is a discretionary grant mechanism using the R01 research project grant format, and it falls under the health funding activity category. The associated CFDA number is 93.837 (Cardiovascular Diseases Research). The opportunity number is PA-07-322, and it was posted January 29, 2007, with multiple receipt dates rather than a single deadline; the announcement remained open across cycles until it was archived on February 2, 2010. There is no cost sharing or matching requirement, which means applicants are not required to provide non-federal matching funds as a condition of the award.

Eligibility is broad and includes many U.S. organization types as well as foreign institutions. Eligible applicants include for-profit organizations (including small businesses and other than small businesses), nonprofits with and without 501(c)(3) status, public and private institutions of higher education, state and local governments (including county, city/township, special district), independent school districts, public housing authorities/Indian housing authorities, and Native American tribal governments and tribal organizations. NIH explicitly notes that foreign institutions are eligible to apply, which can matter for multinational teams or research conducted outside the United States.

For applicants seeking the full details, NIH provided an official announcement page (historically at grants.nih.gov) under PA-07-322. For access or technical issues with the posting, the contact listed is the NIH Office of Extramural Research (OER) webmaster via FBOWebmaster@OD.NIH.GOV, including help for both accessing the announcement and resolving linking problems.

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