Opportunity Information: Apply for PA 10 228
Apply for PA 10 228
- The National Institutes of Health in the education environment food and nutrition health sector is offering a public funding opportunity titled "Structural Biology of Membrane Proteins (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.173 Research Related to Deafness and Communication Disorders 93.279 Drug Abuse and Addiction Research Programs 93.396 Cancer Biology Research 93.837 Cardiovascular Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.859 Biomedical Research and Research Training 93.866 Aging Research.
- This funding opportunity was created on Jul 9, 2010 and posted on Jul 9, 2010.
- Applicants must submit their applications by Sep 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses Native American tribal governments (Federally recognized) Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) County governments State governments Independent school districts City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Private institutions of higher education Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The Structural Biology of Membrane Proteins (R01) funding opportunity (PA 10-228) is a National Institutes of Health (NIH) initiative designed to speed up and improve the process of determining membrane protein structures and to support projects that directly solve the structures of important membrane proteins. Led by NIGMS with participation from multiple NIH Institutes and Centers (including NCI, NIA, NIDCD, NIDDK, NIDA, NIEHS, and NHLBI), the opportunity targets a longstanding bottleneck in biomedical research: membrane proteins are central to signaling, transport, metabolism, and disease, but they are often difficult to produce and study because they are embedded in lipid membranes and can be unstable when removed from that environment. The FOA therefore encourages both technology development and near-term structure determination efforts that can make measurable progress on biologically significant membrane protein targets.
A major emphasis of the announcement is methodological innovation across the full workflow of membrane protein structural biology. Applicants are encouraged to propose new or improved approaches for expression systems and construct design, strategies for oligomerization and complex assembly, and better ways to solubilize membrane proteins while preserving native-like structure and function. The FOA highlights the need for advances in stabilization (for example, through detergents, lipids, nanodiscs, amphipols, or engineered variants), purification pipelines, and rigorous biochemical and biophysical characterization that can confirm sample quality before high-cost structure work begins. It also calls attention to enabling technologies like crystallization methods tailored to membrane proteins (including lipidic cubic phase approaches), isotopic labeling strategies to support NMR, and other sample-preparation innovations that increase throughput and success rates.
On the structure determination side, the FOA explicitly welcomes a broad set of experimental techniques. Proposed work may involve X-ray diffraction, nuclear magnetic resonance (NMR), electron microscopy (including cryo-EM), mass spectrometry, and other biophysical methods appropriate for membrane protein structure and mechanism. The intent is not to restrict applicants to one platform, but to encourage tool development and integrated strategies that overcome practical barriers such as heterogeneity, conformational flexibility, low yields, and instability outside the membrane. Projects that are positioned to deliver high-impact membrane protein structures in the near term are also encouraged, particularly when the targets are unique, biologically important, or otherwise difficult to tackle with standard approaches.
The award mechanism is the NIH Research Project Grant (R01), and the FOA is categorized as a discretionary grant opportunity. A practical reason NIH offers this topic-specific R01 announcement, rather than relying solely on the general investigator-initiated R01 program, is to allow NIH staff to better track community interest, funded activity, and scientific progress in membrane protein structural biology as a defined area. In other words, applicants can still propose R01-type science, but submitting under this FOA helps NIH monitor advances, identify gaps, and potentially shape future investments in the field.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and a range of government entities (state, county, city/township, special district governments, and certain tribal governments and organizations). The announcement also notes eligibility for a variety of institution types such as Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and foreign (non-U.S.) organizations. There is no cost sharing or matching requirement stated for this opportunity.
Key administrative details from the listing include the posted and creation date of July 9, 2010, with an original and current closing date of September 7, 2013, and an archive date of October 8, 2013, indicating the FOA is no longer active. The opportunity is associated with multiple CFDA program areas spanning environmental health, deafness and communication disorders, drug abuse, cancer biology, cardiovascular disease, diabetes/digestive/kidney research, general biomedical research and training, and aging research, reflecting the cross-cutting importance of membrane proteins across many disease areas and biological systems. The official NIH announcement link is provided at http://grants.nih.gov/grants/guide/pa-files/PA-10-228.html, and the NIH Office of Extramural Research (OER) webmaster contacts are listed for access or technical issues.
FAQs: Structural Biology of Membrane Proteins (R01) - PA 10-228
What is the Structural Biology of Membrane Proteins (R01) funding opportunity?
It is an NIH funding opportunity announcement (FOA) titled "The Structural Biology of Membrane Proteins (R01)" (PA 10-228). Its purpose is to speed up and improve membrane protein structure determination and to support projects that directly solve structures of important membrane proteins.
Which NIH organization leads this FOA?
The FOA is led by the National Institute of General Medical Sciences (NIGMS).
Which other NIH Institutes and Centers participate?
Participating NIH Institutes and Centers listed include NCI, NIA, NIDCD, NIDDK, NIDA, NIEHS, and NHLBI.
What scientific problem is this FOA trying to address?
The FOA targets a longstanding bottleneck in biomedical research: membrane proteins are essential to signaling, transport, metabolism, and disease, but they can be difficult to produce and study because they are embedded in lipid membranes and may become unstable when removed from that environment.
What types of projects does the FOA encourage?
The FOA encourages both (1) technology development to improve the membrane protein structural biology pipeline and (2) near-term structure determination projects that can make measurable progress on biologically significant membrane protein targets.
Does the FOA emphasize methodological innovation?
Yes. A major emphasis is methodological innovation across the full workflow of membrane protein structural biology.
What parts of the membrane protein workflow are highlighted for improvement?
The FOA highlights opportunities for advances in expression systems, construct design, strategies for oligomerization and complex assembly, solubilization approaches that preserve native-like structure and function, stabilization methods, purification pipelines, and rigorous biochemical/biophysical characterization to confirm sample quality before starting high-cost structure work.
What stabilization approaches are specifically mentioned?
Examples listed include detergents, lipids, nanodiscs, amphipols, and engineered variants.
What types of sample preparation and enabling technologies are called out?
The FOA calls attention to technologies such as membrane-protein-tailored crystallization methods (including lipidic cubic phase approaches), isotopic labeling strategies to support NMR, and other sample-preparation innovations intended to increase throughput and success rates.
Which experimental structure determination methods are welcomed?
The FOA explicitly welcomes a broad set of experimental techniques, including X-ray diffraction, nuclear magnetic resonance (NMR), electron microscopy (including cryo-EM), mass spectrometry, and other biophysical methods appropriate for membrane protein structure and mechanism.
Is the FOA limited to a single structure determination platform (for example, only X-ray crystallography)?
No. The intent is not to restrict applicants to one platform, but to encourage tool development and integrated strategies that overcome common barriers in membrane protein structural studies.
What practical barriers in membrane protein structural biology does the FOA highlight?
The FOA highlights barriers such as heterogeneity, conformational flexibility, low yields, and instability outside the membrane.
Are near-term structure determination projects encouraged?
Yes. Projects positioned to deliver high-impact membrane protein structures in the near term are encouraged, especially when targets are unique, biologically important, or unusually difficult to tackle with standard approaches.
What is the award mechanism for this opportunity?
The award mechanism is the NIH Research Project Grant (R01).
How is this FOA categorized?
The FOA is categorized as a discretionary grant opportunity.
Why did NIH issue a topic-specific R01 announcement for this area instead of relying only on the general investigator-initiated R01 program?
A stated reason is to allow NIH staff to better track community interest, funded activity, and scientific progress in membrane protein structural biology as a defined area. Submitting under this FOA helps NIH monitor advances, identify gaps, and potentially shape future investments.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic and non-domestic organizations, including public and private higher education institutions, nonprofit organizations (including 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses and other for-profits), and a range of government entities (state, county, city/township, special district governments, and certain tribal governments and organizations).
Are foreign (non-U.S.) organizations eligible?
Yes. The announcement notes eligibility for foreign (non-U.S.) organizations.
Does the FOA mention eligibility for specific institution categories such as HBCUs or Hispanic-serving institutions?
Yes. It notes eligibility for a variety of institution types, including Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and other categories such as faith-based or community-based organizations and regional organizations.
Are U.S. territories or possessions included as eligible applicants?
Yes. The listing notes eligibility for U.S. territories or possessions.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement stated for this opportunity.
Is this funding opportunity currently open?
No. The listing indicates the FOA is no longer active. It shows an original and current closing date of September 7, 2013, and an archive date of October 8, 2013.
What are the posted and creation date and the key closing/archiving dates?
The posted and creation date is July 9, 2010. The original and current closing date is September 7, 2013. The archive date is October 8, 2013.
What CFDA program areas are associated with this opportunity?
The opportunity is associated with multiple CFDA program areas spanning environmental health, deafness and communication disorders, drug abuse, cancer biology, cardiovascular disease, diabetes/digestive/kidney research, general biomedical research and training, and aging research.
What does the range of CFDA areas imply about the scope of membrane protein structural biology?
Based on the listing, it reflects that membrane proteins are cross-cutting and relevant across many disease areas and biological systems.
Where can applicants find the official NIH announcement for PA 10-228?
The official NIH announcement link provided is http://grants.nih.gov/grants/guide/pa-files/PA-10-228.html.
Who is listed for help with access or technical issues?
The listing notes that NIH Office of Extramural Research (OER) webmaster contacts are provided for access or technical issues.
Browse more opportunities from the same category: Education Environment Food and Nutrition Health
Next opportunity: Initiative for Conservation of the Andean Amazon Phase II
Previous opportunity: Abandoned Mine Lands Inventory on Lands to be Conveyed, Alaska statewide
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 10 228
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PA 10 228) also looked into and applied for these:
| Funding Opportunity |
|---|
| Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral MD/PhD and Other Dual Doctoral Degree Fellows (Parent F30) Apply for PA 11 110 Funding Number: PA 11 110 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (Parent F32) Apply for PA 11 113 Funding Number: PA 11 113 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award Short Term Institutional Research Training Grants (Parent T35) Apply for PA 11 185 Funding Number: PA 11 185 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 10 228", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.