Opportunity Information: Apply for PA 14 350
Apply for PA 14 350
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Studies in Neonatal and Pediatric Resuscitation (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Sep 26, 2014 and posted on Sep 25, 2014.
- Applicants must submit their applications by Jan 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses Public housing authorities/Indian housing authorities For profit organizations other than small businesses Private institutions of higher education Native American tribal governments (Federally recognized) Special district governments Native American tribal organizations (other than Federally recognized tribal governments) County governments Independent school districts State governments City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Studies in Neonatal and Pediatric Resuscitation (R01) (Funding Opportunity Number PA-14-350) was a National Institutes of Health (NIH) discretionary grant opportunity designed to spur new, rigorous research that can directly improve how clinicians resuscitate newborns and children. The overall purpose of the announcement was to build stronger evidence around what happens physiologically during the fetal-to-newborn transition and during pediatric emergencies, and then translate that knowledge into practical, evidence-based resuscitation steps and post-resuscitation care. The emphasis was on generating results that can improve both immediate survival and longer-term health outcomes for infants and children who require resuscitation.
The scope of research was intentionally broad. The FOA invited projects addressing key knowledge gaps in neonatal and pediatric resuscitation, including fetal and neonatal transitional cardiovascular and pulmonary physiology, ways to optimize the sequence and timing of resuscitation interventions, and how management of the third stage of labor might affect the fetus and influence resuscitation needs. It also highlighted complex clinical scenarios such as resuscitation of children with congenital malformations, as well as research on how resuscitation practices influence longer-term neurodevelopmental or health outcomes. Another major theme was what happens after return of spontaneous circulation or stabilization, meaning post-resuscitation practices and care pathways that could reduce complications and improve recovery.
A wide range of study designs and methods were considered appropriate, reflecting the reality that resuscitation science benefits from multiple types of evidence. The FOA allowed epidemiologic studies, animal model research focused on fetal or neonatal physiology, and computer-based or information-technology-driven simulations. It also encouraged clinical observational research, secondary analyses of existing national or regional datasets, and opportunistic studies that take advantage of real-world clinical events. Importantly, it also supported prospective randomized controlled trials when feasible, and it explicitly allowed combinations of approaches, which makes it possible to link mechanistic findings to clinical outcomes and implementation strategies.
From an administrative standpoint, this opportunity used the NIH R01 mechanism, meaning it supported full-scale, hypothesis-driven research projects rather than smaller pilot efforts. It fell under the Health activity category and was listed under CFDA 93.865 (Child Health and Human Development Extramural Research). There was no cost sharing or matching requirement, which lowered barriers for applicants who might otherwise struggle to provide institutional matching funds.
Eligibility was broad and inclusive. In addition to typical academic and nonprofit research institutions, eligible applicants included small businesses, for-profit organizations, and a wide variety of government entities (state, county, city/township, special districts, and independent school districts). Tribal governments and tribal organizations were eligible, along with public housing authorities and U.S. territories or possessions. The FOA also specifically recognized and welcomed applications from institutions serving historically underrepresented communities, including HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian serving institutions, and tribally controlled colleges and universities. Foreign organizations and foreign institutions were eligible to apply, and foreign components of U.S. organizations were allowed, consistent with NIH policy.
Key dates indicate that this was a time-limited, now-archived opportunity. It was posted in late September 2014, with an original and final closing date of January 7, 2018, and it was archived on February 7, 2018. While no longer open for submission, the FOA reflects NIH priorities in resuscitation research during that period and outlines the types of questions and study designs NIH considered important for advancing neonatal and pediatric outcomes.
The core takeaway is that PA-14-350 sought to strengthen the scientific foundation of neonatal and pediatric resuscitation by funding studies that clarify physiology, test and refine resuscitation steps, evaluate special populations and circumstances, and link acute interventions to long-term outcomes. The intended impact was clear: turn better research into better resuscitation guidelines and bedside practices so that more newborns and children not only survive resuscitation events, but also do well in the months and years that follow.
Frequently Asked Questions (FAQs)
What is the Studies in Neonatal and Pediatric Resuscitation (R01) opportunity (PA-14-350)?
PA-14-350 was a National Institutes of Health (NIH) discretionary funding opportunity that used the R01 mechanism to support rigorous, hypothesis-driven research aimed at improving how clinicians resuscitate newborns and children. The goal was to generate stronger evidence that can translate into practical, evidence-based resuscitation steps and post-resuscitation care.
What was the main purpose of this FOA?
The announcement aimed to build stronger evidence about (1) physiologic events during the fetal-to-newborn transition and (2) pediatric emergencies requiring resuscitation, and then translate that knowledge into improvements in clinical resuscitation and post-resuscitation practices. The intended impact was better immediate survival and improved longer-term health outcomes for infants and children who require resuscitation.
Which research areas and knowledge gaps did the FOA prioritize?
The scope was broad and invited projects that address key gaps in neonatal and pediatric resuscitation science, including:
- Fetal and neonatal transitional cardiovascular physiology
- Fetal and neonatal transitional pulmonary physiology
- How to optimize the sequence and timing of resuscitation interventions
- How management of the third stage of labor might affect the fetus and influence resuscitation needs
- Resuscitation in complex pediatric scenarios, including children with congenital malformations
- How resuscitation practices influence longer-term neurodevelopmental or health outcomes
- Post-resuscitation practices and care pathways after stabilization or return of spontaneous circulation (ROSC)
Was the FOA limited to neonatal resuscitation, pediatric resuscitation, or both?
Both. The FOA covered neonatal resuscitation topics (including the fetal-to-newborn transition and newborn physiology) and pediatric resuscitation topics (including emergencies in children and complex clinical scenarios).
What kinds of outcomes was NIH trying to improve through this funding opportunity?
The FOA emphasized improving immediate survival during resuscitation events and improving longer-term outcomes after resuscitation, including health and neurodevelopmental outcomes for infants and children.
What does the FOA mean by translating physiology into practice?
The FOA’s intent was to support studies that clarify what is happening physiologically during transition and emergencies, then use that evidence to test, refine, or inform real-world resuscitation steps and post-resuscitation care. The overall aim was to strengthen evidence-based clinical practice and guidelines.
What study designs and research methods were considered appropriate under PA-14-350?
The FOA explicitly supported a wide range of study designs and methods, including:
- Epidemiologic studies
- Animal model research focused on fetal or neonatal physiology
- Computer-based approaches and information-technology-driven simulations
- Clinical observational research
- Secondary analyses of existing national or regional datasets
- Opportunistic studies leveraging real-world clinical events
- Prospective randomized controlled trials (when feasible)
- Combinations of approaches (for example, linking mechanistic findings to clinical outcomes and implementation strategies)
Did the FOA allow randomized controlled trials?
Yes. Prospective randomized controlled trials were supported when feasible, and the FOA also allowed blending trial approaches with other designs to connect mechanistic insights to clinical outcomes.
Did the FOA encourage use of existing datasets?
Yes. The FOA supported secondary analyses of existing national or regional datasets, as well as observational and opportunistic studies that leverage real-world clinical events.
Did the FOA support simulation or technology-based approaches?
Yes. Computer-based and information-technology-driven simulations were specifically described as appropriate methods for resuscitation research under this announcement.
What is the funding mechanism used in this opportunity?
The opportunity used the NIH R01 mechanism, which generally supports full-scale, hypothesis-driven research projects rather than smaller pilot studies.
What activity category was this opportunity listed under?
It was listed under the Health activity category.
What CFDA number was associated with this FOA?
The FOA was listed under CFDA 93.865, Child Health and Human Development Extramural Research.
Was cost sharing or matching required?
No. The FOA stated there was no cost sharing or matching requirement.
Who was eligible to apply?
Eligibility was broad. The FOA allowed applications from a wide range of organization types, including academic and nonprofit research institutions, small businesses, for-profit organizations, and multiple types of government entities.
What types of U.S. government entities were eligible?
The FOA included eligibility for multiple government entity types, including state, county, city/township governments, special districts, and independent school districts. It also included public housing authorities and U.S. territories or possessions.
Were tribal governments and tribal organizations eligible?
Yes. Tribal governments and tribal organizations were eligible applicants under this FOA.
Were institutions serving historically underrepresented communities encouraged to apply?
Yes. The FOA specifically recognized and welcomed applications from institutions serving historically underrepresented communities, including HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian serving institutions, and tribally controlled colleges and universities.
Could foreign organizations apply?
Yes. Foreign organizations and foreign institutions were eligible to apply, consistent with NIH policy.
Were foreign components of U.S. organizations allowed?
Yes. The FOA allowed foreign components of U.S. organizations, consistent with NIH policy.
Is PA-14-350 still open for applications?
No. This was a time-limited opportunity that is now archived and no longer open for submission.
When was the opportunity posted, and what were the closing dates?
It was posted in late September 2014. The original and final closing date was January 7, 2018, and the FOA was archived on February 7, 2018.
What was the significance of the post-resuscitation focus in this FOA?
The FOA emphasized that what happens after stabilization or return of spontaneous circulation (ROSC) can affect complications and recovery. It therefore encouraged research on post-resuscitation practices and care pathways intended to improve recovery and outcomes.
How did this FOA define its intended impact?
The intended impact was to strengthen the scientific foundation of neonatal and pediatric resuscitation and translate findings into improved guidelines and bedside practices, so that more newborns and children survive resuscitation events and do well in the months and years afterward.
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