Studies in Neonatal Resuscitation (R01) | Apply Online

Opportunity Summary:

The Studies in Neonatal Resuscitation (R01) opportunity, Funding Opportunity Number PAR 11-222, is a National Institutes of Health (NIH) discretionary grant program designed to encourage and expand research focused on neonatal resuscitation. The central aim is to generate strong scientific evidence that can be translated into improved, evidence-based practices for stabilizing newborns at birth, supporting a smoother transition from fetal to neonatal life, and ultimately improving both short-term and long-term outcomes for infants who require assistance immediately after delivery.

This funding announcement is intentionally broad in scope and invites research across a wide range of neonatal resuscitation topics. It highlights interest in studies examining fetal-to-neonatal transitional physiology, including cardiovascular and pulmonary changes that occur at birth, since understanding these mechanisms can inform better interventions when transition does not occur smoothly. It also encourages projects that refine and optimize specific steps of resuscitation, which may include evaluating timing, sequencing, and effectiveness of interventions used in delivery rooms. Another emphasis is the management of the third stage of labor and how practices during this period might affect the fetus or newborn, along with research on resuscitation approaches for infants with congenital malformations. The announcement also underscores the importance of understanding how resuscitation techniques and early stabilization strategies may influence longer-term developmental, neurologic, and health outcomes.

The FOA supports many types of study designs, reflecting the complexity of neonatal resuscitation research and the need for both foundational and applied evidence. Applicants may propose epidemiological studies, animal model research focused on fetal or neonatal physiology, and simulation-based research using computer models or other information technology approaches. Clinical research is also explicitly encouraged and may include observational studies, analyses of existing national or regional datasets, and prospective randomized controlled trials. Mixed-method or combined approaches are allowable as well, meaning applicants can integrate multiple study strategies to strengthen findings and improve real-world applicability.

Administratively, this is an NIH R01 grant mechanism within the Health activity category and is associated with CFDA number 93.865 (Child Health and Human Development Extramural Research), indicating alignment with child health and developmental research priorities. The program does not require cost sharing or matching funds. The announcement was posted and created on June 8, 2011, with an original and final closing date of September 19, 2013, and an archive date of October 20, 2013, meaning it is no longer active but remains useful as a reference for the kinds of neonatal resuscitation projects NIH has sought to fund.

Eligibility is broad and includes a wide array of domestic U.S. organizations and governmental entities, such as state, county, city or township governments, special district governments, independent school districts, and public housing authorities. Higher education institutions are eligible, including public/state-controlled and private institutions. Nonprofit organizations are eligible both with and without 501(c)(3) status (with the non-501(c)(3) category excluding institutions of higher education), and for-profit entities are eligible as well, including small businesses and other for-profit organizations. The FOA also includes eligibility for tribal governments and tribal organizations, as well as specific categories of institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations. Notably, non-U.S. entities (foreign organizations) are allowed, and foreign components of U.S. organizations are also permitted, along with regional organizations and U.S. territories or possessions, reflecting NIH’s openness to internationally relevant collaborations where appropriate.

Overall, the opportunity is aimed at building a stronger scientific foundation for neonatal resuscitation by supporting rigorous studies that can clarify physiology, test interventions, leverage data resources, and evaluate outcomes over time. The intended end result is practical: better evidence to guide clinicians and health systems toward resuscitation practices that improve survival and health trajectories for newborn infants, including those with special medical needs at birth.

For full historical details, the archived announcement was available through NIH at: http://grants.nih.gov/grants/guide/pa-files/PAR-11-222.html (formatting may vary depending on how the link is accessed).

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