Opportunity Information: Apply for RFA RM 14 008
Apply for RFA RM 14 008
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Study of Nuclear Bodies and Compartments (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Sep 24, 2014 and posted on Sep 24, 2014.
- Applicants must submit their applications by Feb 2, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Eligible applicants include: For profit organizations other than small businesses Public housing authorities/Indian housing authorities State governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Native American tribal governments (Federally recognized) Small businesses City or township governments Independent school districts Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Study of Nuclear Bodies and Compartments (U01) opportunity (Funding Opportunity Number RFA-RM-14-008) is a National Institutes of Health (NIH) discretionary funding announcement that uses the U01 cooperative agreement mechanism to support research projects focused on understanding how the cell nucleus is organized and how that organization influences genome function. The central aim is tool and strategy development rather than purely descriptive biology, with an emphasis on enabling researchers to map, visualize, perturb, and interpret subnuclear organization in ways that were not previously possible or practical.
Scientifically, the announcement targets three tightly related areas. First, it seeks approaches for studying the three-dimensional architecture of the nucleus in relation to the physical placement and behavior of nuclear bodies and transcriptional machinery. This includes work that connects nuclear geometry and spatial genome organization to where transcription happens, how transcriptional complexes are arranged, and how nuclear bodies may help concentrate, exclude, or organize key regulators. Second, it encourages investigations into nuclear structures that remain poorly characterized, meaning compartments or bodies whose composition, formation rules, dynamics, or functional roles are not yet well understood. Projects in this area would be expected to move beyond naming or imaging a structure and instead clarify what it is made of, how it forms and changes over time, and what it does for gene expression, RNA processing, chromatin regulation, DNA repair, or other nuclear processes. Third, it supports studies on the role of specialized proteins and RNAs in building and maintaining nuclear bodies and subnuclear domains, including how these molecules drive assembly, organization, and function. That can include identifying scaffold or seed components, dissecting RNA-protein interactions that promote compartmentalization, and testing mechanistic models for how compartments emerge and influence nuclear activities.
From an administrative and funding standpoint, this is a cooperative agreement, which generally means the NIH anticipates substantial scientific or programmatic involvement during the course of the award compared with a standard research grant. The funding activity category is Health, and the CFDA listing is 93.310 (Trans-NIH Research Support), reflecting that the topic is relevant across multiple NIH Institutes and Centers. The announcement was posted on September 24, 2014, with an application due date of February 2, 2015, and it was later archived on March 5, 2015. The estimated total funding for the program is listed as $3,000,000, and there is no cost-sharing or matching requirement.
Eligibility is broad and includes many U.S. and non-U.S. organization types. Eligible applicants include public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities); for-profit organizations (including small businesses and other for-profits); and multiple levels of government such as state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The announcement explicitly includes participation from a range of mission-driven and capacity-building institutions and organizations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations and eligible federal agencies. It also allows non-domestic (non-U.S.) entities, foreign organizations and foreign institutions, non-domestic components of U.S. organizations, and foreign components as defined in the NIH Grants Policy Statement, indicating that international expertise and collaboration are considered appropriate for the goals of the program.
For applicants seeking the original, full technical requirements and any special cooperative agreement expectations, the official NIH guide page is provided in the announcement (http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-14-008.html). For access issues or linking problems, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs): The Study of Nuclear Bodies and Compartments (U01) - RFA-RM-14-008
What is the title of this funding opportunity?
The opportunity is titled The Study of Nuclear Bodies and Compartments (U01).
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-RM-14-008.
Which agency is offering this grant opportunity?
This is a National Institutes of Health (NIH) funding opportunity.
What type of funding announcement is this?
It is described as an NIH discretionary funding announcement.
What award mechanism does this opportunity use?
The opportunity uses the U01 cooperative agreement mechanism.
What does it mean that this is a cooperative agreement (U01)?
As a cooperative agreement, the NIH generally anticipates substantial scientific or programmatic involvement during the course of the award compared with a standard research grant.
What is the main scientific goal of this opportunity?
The central goal is to support research that improves understanding of how the cell nucleus is organized and how that organization influences genome function, with a strong emphasis on developing tools and strategies rather than conducting purely descriptive biology.
Is the emphasis on basic description of nuclear structures, or on enabling methods?
The emphasis is on tool and strategy development. The announcement highlights enabling researchers to map, visualize, perturb, and interpret subnuclear organization in ways that were not previously possible or practical.
What kinds of capabilities or outcomes does NIH want projects to enable?
Projects are expected to enable improved ways to map subnuclear organization, visualize nuclear bodies and compartments, perturb subnuclear organization experimentally, and interpret how nuclear organization relates to genome function.
What are the major scientific areas targeted by the announcement?
The announcement targets three closely related areas: (1) approaches to study the three-dimensional nuclear architecture and its relationship to nuclear bodies and transcriptional machinery; (2) investigations into poorly characterized nuclear structures; and (3) studies of specialized proteins and RNAs that build and maintain nuclear bodies and subnuclear domains.
What does the opportunity mean by studying 3D nuclear architecture?
It includes approaches that connect nuclear geometry and spatial genome organization to where transcription happens, how transcriptional complexes are arranged, and how nuclear bodies may concentrate, exclude, or organize key regulators.
How does transcription relate to the focus of this program?
The program is interested in how nuclear architecture relates to the placement and behavior of transcriptional machinery, including where transcription occurs and how transcriptional complexes may be organized within the nuclear space.
What types of nuclear bodies or compartments are in scope?
The opportunity includes nuclear bodies and compartments broadly, including those that are poorly characterized in terms of composition, formation rules, dynamics, or functional roles.
What does NIH mean by "poorly characterized" nuclear structures?
These are compartments or bodies whose composition, formation rules, dynamics, or functional roles are not yet well understood.
What is expected of projects focused on poorly characterized nuclear structures?
Projects are expected to go beyond simply naming or imaging a structure and instead clarify what it is made of, how it forms, how it changes over time, and what it does for nuclear functions.
Which nuclear functions are specifically mentioned as relevant?
The announcement specifically mentions potential roles in gene expression, RNA processing, chromatin regulation, DNA repair, and other nuclear processes.
What is the role of proteins and RNAs in this opportunity?
A major focus area is understanding how specialized proteins and RNAs help build and maintain nuclear bodies and subnuclear domains, including how these molecules drive assembly, organization, and function.
What kinds of molecular studies are encouraged under the protein/RNA focus?
Examples given include identifying scaffold or seed components, dissecting RNA-protein interactions that promote compartmentalization, and testing mechanistic models for how compartments emerge and influence nuclear activities.
What is the funding activity category?
The funding activity category is listed as Health.
What is the CFDA number for this opportunity?
The CFDA listing is 93.310 (Trans-NIH Research Support).
What does "Trans-NIH" imply in this context?
It indicates the topic is relevant across multiple NIH Institutes and Centers.
When was this announcement posted?
The announcement was posted on September 24, 2014.
What was the application due date?
The application due date was February 2, 2015.
Is this funding opportunity still active?
No. The opportunity was archived on March 5, 2015.
How much total funding is estimated for the program?
The estimated total funding for the program is $3,000,000.
Is cost sharing or matching required?
No. The announcement states there is no cost-sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes many U.S. and non-U.S. organization types, including higher education institutions, nonprofits, for-profits, and multiple levels of government organizations.
Are U.S. public and private institutions of higher education eligible?
Yes. The announcement includes public and private institutions of higher education as eligible applicants.
Are nonprofit organizations eligible?
Yes. Eligible applicants include nonprofit organizations, including 501(c)(3) and non-501(c)(3) entities.
Are for-profit organizations eligible?
Yes. Eligible applicants include for-profit organizations, including small businesses and other for-profits.
Are government entities eligible to apply?
Yes. Eligible government applicants include state, county, city/township, and special district governments, as well as independent school districts and public housing authorities/Indian housing authorities.
Are HBCUs specifically included as eligible applicants?
Yes. The announcement explicitly includes Historically Black Colleges and Universities (HBCUs).
Are Hispanic-serving Institutions eligible?
Yes. Hispanic-serving Institutions are explicitly listed as included.
Are Tribally Controlled Colleges and Universities (TCCUs) eligible?
Yes. Tribally Controlled Colleges and Universities (TCCUs) are explicitly included.
Are Alaska Native and Native Hawaiian Serving Institutions eligible?
Yes. The announcement explicitly includes Alaska Native and Native Hawaiian Serving Institutions.
Are AANAPISIs eligible?
Yes. The announcement explicitly includes Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. The announcement states that faith-based or community-based organizations are included among eligible applicants.
Are eligible federal agencies allowed to participate?
Yes. The announcement includes eligible federal agencies among eligible applicants.
Are non-U.S. (international) organizations eligible to apply?
Yes. The announcement allows non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions.
Can a U.S. organization include a non-domestic component?
Yes. The announcement allows non-domestic components of U.S. organizations and foreign components as defined in the NIH Grants Policy Statement.
Does the announcement suggest NIH welcomes international expertise or collaboration?
Yes. By allowing foreign organizations and foreign components, the announcement indicates international expertise and collaboration are considered appropriate for the program goals.
Where can applicants find the official NIH guide page for the full announcement?
The official NIH guide page is provided as: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-14-008.html.
Who should be contacted if there are access issues or linking problems with the official page?
The contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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