Sub Saharan African Collaborative HIV and Cancer Consortia (U54) | Apply Online

Opportunity Summary:

The Sub Saharan African Collaborative HIV and Cancer Consortia (U54) opportunity (Funding Opportunity Number RFA-CA-13-010) is a National Institutes of Health (NIH) cooperative agreement designed to strengthen and expand research on HIV-associated cancers in sub-Saharan Africa through structured, long-term collaboration between institutions and investigators based in the United States and those based in sub-Saharan African countries. The central idea is to build consortia that can tackle cancer problems that are especially urgent in African settings where HIV is prevalent, while also building local research capacity and creating durable partnerships that can keep producing impactful science beyond the life of a single project.

This FOA supports applications for Specialized Center Cooperative Agreements (U54), which means awardees should expect an active partnership with NIH program staff rather than a hands-off grant mechanism. The consortium model is intended to bring multiple related projects under one coordinated umbrella, so the whole is stronger than any single study alone. Applications must include two to four linked research projects that address high-priority questions relevant to the participating African country or countries. The scope is intentionally broad: projects can range from basic laboratory science to translational research, as well as population-based, epidemiologic, and implementation-focused studies that look at how to deliver effective cancer prevention, screening, diagnosis, or care in real-world settings. At the same time, the announcement clearly states that clinical trials will not be supported under this FOA, so applicants need to design studies that stop short of interventional clinical trial activity while still producing actionable evidence.

A defining feature of the program is its required infrastructure, built through two mandatory cores that every application must include. First, an Administrative/Coordinating Core is required to manage the consortium, keep the projects aligned, coordinate communications and data/resource sharing, handle regulatory and operational logistics, and generally ensure that the collaboration functions smoothly across institutions and countries. Second, a Mentoring/Career Development Core is required to cultivate the next generation of researchers, with an emphasis on training and mentorship that strengthens scientific leadership and research independence, particularly in the African partner institutions. Applicants may also propose additional cores when they are justified by the scientific needs of the projects, such as shared technical resource cores (for example, pathology support, biostatistics, informatics, specimen processing, or other centralized capabilities that multiple projects will use). The expectation is that these shared resources will improve efficiency, standardize methods, and raise the overall quality and reproducibility of the consortiums work.

In terms of eligible applicants, the FOA is open to a wide range of organizations, including public and private institutions of higher education, state governments, and nonprofit organizations (both those with and without 501(c)(3) status), as well as other eligible entities described in the full announcement. The eligibility language explicitly includes several types of minority-serving institutions and tribally controlled institutions (such as HBCUs, Hispanic-serving institutions, AANAPISIs, and TCCUs). Importantly, foreign organizations are eligible to apply if they are located in sub-Saharan African countries, reflecting the program goal of centering African institutional participation rather than treating it as purely a subcontracting role. In addition, non-U.S. components of U.S. organizations may apply without geographic restriction, and foreign components as defined by NIH policy are allowed.

Administratively, the opportunity is categorized as a discretionary funding program using a cooperative agreement instrument, and it sits within NIH activity areas spanning cancer biology, prevention, detection/diagnosis, treatment research, and cancer control, along with international research and research training (CFDA numbers listed include 93.393, 93.394, 93.395, 93.396, 93.399, and 93.989). The posted date for the announcement was October 25, 2013, with an original application due date of January 17, 2014, later extended to January 27, 2014. The award ceiling is listed as $750,000, and there is no cost sharing or matching requirement, which can make budgeting more straightforward for consortia that need to support cross-site coordination, training activities, and shared research infrastructure.

Overall, this FOA is aimed at creating well-coordinated, multi-project research centers that can answer pressing questions about HIV-associated cancers in sub-Saharan Africa while simultaneously developing sustainable research capacity through formal coordination structures and strong mentoring and career development. It is not simply a call for isolated studies; it is a call to build an integrated research and training ecosystem that can produce high-quality evidence relevant to local needs and strengthen the long-term ability of African and U.S. partners to address the intersecting burdens of HIV and cancer.

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