Opportunity Information: Apply for RFA HL 16 002
Apply for RFA HL 16 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Sudden Cardiac Death in the Young Population Based Studies (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research.
- This funding opportunity was created on Feb 25, 2015 and posted on Feb 25, 2015.
- Applicants must submit their applications by Jun 15, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $540,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: County governments Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments For profit organizations other than small businesses State governments Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The funding opportunity titled "Sudden Cardiac Death in the Young Population Based Studies (U01)" (Funding Opportunity Number RFA-HL-16-002) is a National Institutes of Health (NIH) cooperative agreement designed to support research focused on sudden cardiac death (SCD) in young people. The central goal is to fund mechanistic, genetic, and related studies that can clarify the causes of sudden cardiac death in the young, identify risk factors that increase the likelihood of these events, and better understand the consequences for families and populations. A key requirement is that funded projects must build their research on the existing infrastructure of the Sudden Death in the Young Case Registry, specifically using the registry data and DNA samples as the foundation for proposed analyses. In practical terms, this FOA is looking for studies that can leverage population-based case information and biospecimens to produce stronger, more generalizable evidence than what is often possible from single-center case series.
This opportunity uses the U01 mechanism, which is a cooperative agreement rather than a traditional research grant. That typically means there is substantial scientific and/or programmatic involvement from the NIH during the conduct of the project. Applicants should be prepared for a more collaborative relationship with NIH staff, which can include coordination on milestones, data sharing expectations, and alignment with program priorities tied to the registry resource. The funding activity category is health, and the CFDA listing is 93.837 (Cardiovascular Diseases Research), placing it squarely within NIH-supported cardiovascular research efforts.
The FOA anticipated making around three awards, with an estimated total funding level of approximately $2,500,000. The stated award ceiling is $540,000, signaling that individual projects are expected to fit within a defined upper budget range. There is no cost-sharing or matching requirement, so applicants are not required to contribute non-federal funds as a condition of the award. The opportunity was posted on February 25, 2015, with an original and current closing date of June 15, 2015, and an archive date of July 16, 2015, indicating the solicitation is now historical rather than open, but still useful as a reference for the kind of work NIH sought to support.
Eligibility is broad and includes many types of domestic organizations. Eligible applicants include state, county, city or township governments; special district governments; public housing authorities/Indian housing authorities; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with and without 501(c)(3) status (with the noted exception language regarding institutions of higher education); small businesses; and for-profit organizations other than small businesses. The eligibility language also explicitly references a wide set of institution types and community-based entities such as historically black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISISs). Faith-based or community-based organizations and eligible federal agencies are also included, along with regional organizations and U.S. territories or possessions. At the same time, the FOA clearly excludes non-U.S. applicants: non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed. This keeps the work fully domestic, consistent with the use of a U.S.-based case registry and associated DNA resources.
In terms of the science, the FOA emphasizes studies that can illuminate underlying mechanisms and genetics of sudden cardiac death in the young, while also addressing broader contributors and outcomes. Because the registry is a required foundation, the emphasis is on population-based insights rather than narrowly selected clinical cohorts. Projects responsive to this FOA would likely center on analyzing registry case information, linking or integrating phenotypic and epidemiologic data, and performing genetic or genomic analyses using the provided DNA samples. The overall intent is to improve understanding of why these deaths happen, what warning signs or risk factors might be detectable, and what the downstream implications are for prevention strategies, screening approaches, family counseling, and public health planning.
For applicants or readers seeking the official announcement details, NIH provided an additional information link to the full FOA text at http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-16-002.html. For technical issues accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, with guidance to use that contact for both access difficulties and linking problems.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The funding opportunity is titled "Sudden Cardiac Death in the Young Population Based Studies (U01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-HL-16-002.
Which agency is offering this opportunity?
This opportunity is offered by the National Institutes of Health (NIH).
What is the main goal of the FOA?
The central goal is to support research focused on sudden cardiac death (SCD) in young people, including mechanistic, genetic, and related studies that clarify causes, identify risk factors, and improve understanding of consequences for families and populations.
What research areas or types of studies are emphasized?
The FOA emphasizes mechanistic, genetic, and related studies of sudden cardiac death in the young. It highlights work that can use population-based case information and biospecimens to generate more generalizable evidence than single-center case series.
Is use of the Sudden Death in the Young Case Registry required?
Yes. A key requirement is that proposed projects must build their research on the existing infrastructure of the Sudden Death in the Young Case Registry, specifically using registry data and DNA samples as the foundation for the analyses.
What kinds of data or materials are expected to be used?
Studies are expected to leverage population-based case information from the registry and use DNA samples associated with the registry as a foundation for genetic or genomic analyses.
Why does the FOA emphasize population-based studies?
Because projects must be built on the registry, the intent is to support research that can produce stronger, more generalizable findings than what is often possible from narrowly selected cohorts or single-center case series.
What funding mechanism is used (U01)?
The FOA uses the U01 mechanism, which is an NIH cooperative agreement rather than a traditional research grant.
What does it mean that this is a cooperative agreement?
A cooperative agreement typically involves substantial scientific and/or programmatic involvement from NIH during the project. Applicants should expect a more collaborative relationship that may include coordination on milestones, data sharing expectations, and alignment with program priorities tied to the registry resource.
What is the funding activity category and CFDA number?
The funding activity category is health. The CFDA listing is 93.837 (Cardiovascular Diseases Research).
How many awards were anticipated?
The FOA anticipated making around three awards.
What was the estimated total funding level?
The estimated total funding level was approximately $2,500,000.
What is the award ceiling for an individual project?
The stated award ceiling is $540,000, indicating individual projects were expected to fit within a defined upper budget range.
Is cost-sharing or matching required?
No. There is no cost-sharing or matching requirement.
Is this FOA currently open for applications?
No. The opportunity is historical. It was posted on February 25, 2015, had a closing date of June 15, 2015, and an archive date of July 16, 2015.
When was the FOA posted?
The FOA was posted on February 25, 2015.
What was the application closing date?
The original and current closing date listed is June 15, 2015.
What is the archive date and what does it imply?
The archive date is July 16, 2015, which indicates the solicitation is archived and no longer active for new submissions, though it can still be referenced for the type of work NIH sought to support.
Who was eligible to apply?
Eligibility was broad for domestic organizations and included: state, county, city, or township governments; special district governments; public housing authorities/Indian housing authorities; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with and without 501(c)(3) status (with noted exception language regarding institutions of higher education); small businesses; and for-profit organizations other than small businesses.
Are community-based and faith-based organizations included in eligibility?
Yes. The eligibility language explicitly includes faith-based or community-based organizations.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The FOA explicitly references a wide set of institution types, including historically black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISISs).
Are U.S. territories or possessions eligible?
Yes. The eligibility language includes U.S. territories or possessions.
Are federal agencies eligible to apply?
Yes. The eligibility language includes eligible federal agencies.
Are foreign (non-U.S.) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply.
Can a U.S. organization apply if it proposes a non-U.S. component?
No. The FOA states that non-domestic components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed.
Why is eligibility limited to domestic applicants and components?
The FOA keeps the work fully domestic, consistent with using a U.S.-based case registry and associated DNA resources.
What outcomes or impacts does NIH appear to be aiming for with this research?
The intent is to improve understanding of why sudden cardiac deaths happen in young people, identify warning signs or risk factors, and clarify downstream implications for prevention strategies, screening approaches, family counseling, and public health planning.
Where can I find the official FOA announcement text?
The FOA text is available at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-16-002.html
Who should be contacted for technical issues accessing the announcement?
The contact listed for technical issues (access difficulties and linking problems) is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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