Opportunity Information: Apply for CDC RFA DP14 1403
Apply for CDC RFA DP14 1403
- The NCCDPHP in the health sector is offering a public funding opportunity titled "Sudden Death in the Young (SDY) Registry" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.946 Cooperative Agreements to Support State Based Safe Motherhood and Infant Health Initiative Programs.
- This funding opportunity was created on Jun 6, 2014 and posted on May 1, 2014.
- Applicants must submit their applications by Jun 30, 2014 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $635,875.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- The number of recipients for this funding is limited to 14 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) State governments.
- State Health Departments or their bona fide agents. Individuals, foreign entities, and sole proprietorship organizations are not eligible to compete for, or receive, awards made under this announcement.
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Opportunity Summary:
The Sudden Death in the Young (SDY) Registry funding opportunity (CDC RFA DP14-1403) is a CDC-led cooperative agreement designed to build stronger, prospectively collected public health data on sudden, unexpected deaths among infants, children, adolescents, and young adults. SDY events are especially traumatic for families and communities and often trigger intense public concern and media attention, yet the public health and clinical response has been hampered by limited, inconsistent epidemiologic information. The core purpose of this program is to improve understanding of how often SDY occurs, what causes it, and which risk factors might be preventable or detectable earlier, so that screening and prevention policies can be based on solid evidence rather than assumptions or incomplete case reports.
The opportunity reflects the reality that SDY can stem from multiple underlying conditions, many of which may be heritable or difficult to detect without targeted evaluation. The announcement highlights several well recognized contributors to sudden cardiac death in the young, including hypertrophic cardiomyopathy, anomalous coronary arteries (especially wrong sinus origin), arrhythmogenic right ventricular cardiomyopathy, and ion channel disorders (channelopathies) that can trigger lethal arrhythmias. It also emphasizes neurologic contributors, particularly genetic forms of epilepsy such as Dravet Syndrome, and it connects SDY to related syndromes such as Sudden Infant Death Syndrome (SIDS) and Sudden Unexpected Death in Epilepsy (SUDEP). Notably, the announcement points out that a meaningful share of cases remain unexplained even after autopsy, with up to about 30 percent described as "autopsy negative" sudden cardiac death in the young, underscoring the need for improved investigation and standardized data capture. It further notes that sudden cardiac death has been documented across all ages and may occur in association with competitive athletics, and that an estimated 10 to 15 percent of SIDS cases may be due to ion channelopathies, suggesting overlap between cardiac electrical disorders and some infant deaths previously categorized as unexplained.
To close these knowledge gaps, CDC partnered with two NIH institutes, the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Neurological Disorders and Stroke (NINDS), to develop the SDY Registry. In practical terms, the registry effort is meant to create a more uniform, prospective approach to identifying SDY cases and documenting key information such as circumstances of death, medical and family history, autopsy findings when available, and suspected etiologies across cardiac and neurologic pathways. The long-term public health value is that better incidence estimates and clearer etiologic patterns can inform rational policy and program decisions, including how to target prevention strategies, how to approach screening questions, and how to improve investigation practices when a sudden death occurs.
Administratively, this is a discretionary health grant mechanism offered as a cooperative agreement, meaning recipients should expect substantial involvement and collaboration with CDC rather than a hands-off grant relationship. The program anticipated about 14 awards, with total estimated funding of $635,875. Individual awards were expected to range from a floor of $25,000 up to a ceiling of $200,000, and there was no cost sharing or matching requirement. Eligible applicants were limited to state health departments or their bona fide agents; individuals, foreign entities, and sole proprietorships were explicitly not eligible. The CFDA number listed is 93.946, and the sponsoring CDC area is NCCDPHP.
Key dates included a posted date of May 1, 2014, with applications due June 30, 2014 (electronically submitted by 11:59 p.m. Eastern Time), and an archive date of July 30, 2014. The opportunity also included a formatting amendment dated May 30, 2014 that set specific application preparation rules: single-spaced text using Calibri 12-point font with 1-inch margins, numbered pages, and clarified page limits. The table of contents had no page limit and did not count toward the project narrative limit. The project abstract was limited to a maximum of 1 page. The project narrative, including the work plan, was limited to 25 pages, and any pages beyond that limit would not be reviewed or considered.
For support or access issues related to the full announcement, the contact listed was Lena Camperlengo at gtx6@cdc.gov.
Frequently Asked Questions (FAQs): Sudden Death in the Young (SDY) Registry (CDC RFA DP14-1403)
What is the SDY Registry funding opportunity (CDC RFA DP14-1403)?
The Sudden Death in the Young (SDY) Registry funding opportunity (CDC RFA DP14-1403) is a CDC-led cooperative agreement intended to strengthen prospectively collected public health data on sudden, unexpected deaths among infants, children, adolescents, and young adults.
What is the main purpose of the SDY Registry program?
The core purpose is to improve understanding of how often SDY occurs, what causes it, and which risk factors might be preventable or detectable earlier, so that screening and prevention policies can be based on solid evidence rather than assumptions or incomplete case reports.
Why is this program needed?
SDY events are traumatic for families and communities and can generate intense public concern and media attention. Public health and clinical responses have been limited by inconsistent and incomplete epidemiologic information. The registry is designed to close those data gaps through more uniform and prospective case identification and documentation.
What age groups are included in the SDY Registry focus?
The program focuses on sudden, unexpected deaths among infants, children, adolescents, and young adults.
What kinds of conditions can contribute to sudden death in the young, according to the announcement?
The announcement highlights multiple underlying contributors across cardiac and neurologic pathways. Cardiac contributors include hypertrophic cardiomyopathy, anomalous coronary arteries (especially wrong sinus origin), arrhythmogenic right ventricular cardiomyopathy, and ion channel disorders (channelopathies) that can trigger lethal arrhythmias. Neurologic contributors include genetic forms of epilepsy such as Dravet Syndrome.
How does the opportunity relate to SIDS and SUDEP?
The announcement connects SDY to related syndromes including Sudden Infant Death Syndrome (SIDS) and Sudden Unexpected Death in Epilepsy (SUDEP), reflecting overlap between sudden death events and underlying cardiac and neurologic mechanisms.
What does "autopsy negative" sudden cardiac death mean in this context?
The announcement notes that a meaningful share of cases remain unexplained even after autopsy, with up to about 30 percent described as "autopsy negative" sudden cardiac death in the young. This underscores the need for improved investigation and standardized data capture.
Does the announcement mention sudden death in athletes?
Yes. It notes that sudden cardiac death has been documented across all ages and may occur in association with competitive athletics.
What does the opportunity say about ion channel disorders and SIDS?
It notes that an estimated 10 to 15 percent of SIDS cases may be due to ion channelopathies, suggesting that cardiac electrical disorders may account for some infant deaths that were previously categorized as unexplained.
Which agencies partnered to develop the SDY Registry?
CDC partnered with two NIH institutes: the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Neurological Disorders and Stroke (NINDS).
What is expected to be collected or documented through the registry effort?
The registry effort is intended to create a more uniform, prospective approach to identifying SDY cases and documenting key information such as the circumstances of death, medical and family history, autopsy findings when available, and suspected etiologies across cardiac and neurologic pathways.
What is the intended long-term public health value of the SDY Registry?
Better incidence estimates and clearer etiologic patterns can support more rational policy and program decisions, including how to target prevention strategies, how to approach screening questions, and how to improve investigation practices following a sudden death.
What type of grant mechanism is this opportunity?
This is a discretionary health grant mechanism offered as a cooperative agreement.
What does it mean that this is a cooperative agreement?
A cooperative agreement implies substantial involvement and collaboration with CDC, rather than a hands-off grant relationship.
How many awards were anticipated?
The program anticipated about 14 awards.
What was the total estimated funding amount?
The total estimated funding was $635,875.
What was the expected award size range?
Individual awards were expected to range from $25,000 (floor) to $200,000 (ceiling).
Was cost sharing or matching required?
No. There was no cost sharing or matching requirement.
Who was eligible to apply?
Eligible applicants were limited to state health departments or their bona fide agents.
Who was explicitly not eligible to apply?
Individuals, foreign entities, and sole proprietorships were explicitly not eligible.
What is the CFDA number for this opportunity?
The CFDA number listed is 93.946.
What is the sponsoring CDC area?
The sponsoring CDC area is NCCDPHP.
When was the opportunity posted?
The posted date was May 1, 2014.
When were applications due?
Applications were due June 30, 2014, with electronic submission required by 11:59 p.m. Eastern Time.
When was the opportunity archived?
The archive date was July 30, 2014.
Was there an amendment to the application instructions?
Yes. A formatting amendment dated May 30, 2014 set specific application preparation rules and clarified page limits.
What formatting rules were specified in the May 30, 2014 amendment?
The amendment specified single-spaced text using Calibri 12-point font with 1-inch margins, and required numbered pages.
What were the page limits for the application components?
The table of contents had no page limit and did not count toward the project narrative limit. The project abstract was limited to a maximum of 1 page. The project narrative, including the work plan, was limited to 25 pages.
What happens if the project narrative exceeds the page limit?
Any pages beyond the 25-page project narrative limit would not be reviewed or considered.
Who is the contact for support or access issues related to the full announcement?
The contact listed is Lena Camperlengo at gtx6@cdc.gov.
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