Opportunity Information: Apply for PAR 13 280

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Support of NIGMS Program Project Grants (P01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research 93.859 Biomedical Research and Research Training.
  • This funding opportunity was created on Jul 19, 2013 and posted on Jul 19, 2013.
  • Applicants must submit their applications by Sep 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Native American tribal governments (Federally recognized) State governments Special district governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Independent school districts Private institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses City or township governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

Support of NIGMS Program Project Grants (P01) (Funding Opportunity Number PAR-13-280) is a National Institutes of Health funding announcement from the National Institute of General Medical Sciences (NIGMS) that invites applications for Program Project (P01) grants focused on major questions in fundamental biological research. The central idea of this opportunity is to back large, coordinated research efforts where multiple investigators and projects work together on a shared, significant biological problem that fits the NIGMS mission. Rather than funding a set of separate projects that happen to be related, NIGMS is looking for tightly connected, interactive science where the overall program is stronger than the sum of its parts. The expectation is that collaboration among outstanding scientists will create clear scientific advantages, such as shared approaches, complementary expertise, integrated experimental strategies, and cross-project insights that would be difficult to achieve if each project were supported as an individual standard research grant.

This announcement supports research in the broad NIH health and biomedical research area, with an emphasis aligned to NIGMS priorities in foundational biomedical science and research training. The mechanism is a grant, and it falls under the discretionary category. It is associated with CFDA numbers 93.172 (Human Genome Research) and 93.859 (Biomedical Research and Research Training, a category often used for NIGMS-related programs). Importantly, there is no cost sharing or matching requirement listed, meaning applicants are not required to commit non-federal matching funds as a condition of eligibility, though normal NIH budget and cost principles would still apply.

Eligibility is broad across U.S.-based organizations and public entities. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including those with 501(c)(3) status and certain nonprofits without 501(c)(3) status, other than institutions of higher education), for-profit organizations (other than small businesses), and small businesses. It also includes a wide range of governmental and quasi-governmental bodies such as state governments, county governments, city or township governments, special district governments, and independent school districts, as well as public housing authorities and Indian housing authorities. Tribal eligibility is also explicitly recognized, including federally recognized Native American tribal governments and tribal organizations that are not federally recognized. The announcement further clarifies additional eligible applicant types, including various minority-serving institutions and community-based entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.

At the same time, the FOA sets clear limits regarding non-U.S. participation. Non-domestic (non-U.S.) entities, meaning foreign institutions, are not eligible to apply as the applicant organization. Non-domestic components of U.S. organizations are also not eligible to apply as applicant components. However, the FOA allows "foreign components" as defined under the NIH Grants Policy Statement, which typically means a U.S. applicant can include certain foreign work or foreign collaborators when well-justified and consistent with NIH policy, even though a foreign institution cannot serve as the main applicant.

From an administrative standpoint, the opportunity was posted and created on July 19, 2013. The original and final listed closing date is September 7, 2016, and the archive date is October 8, 2016, indicating the FOA is no longer active for new submissions under that specific announcement. Applicants looking for a current version of this program would normally search NIH and NIGMS listings for the most recent P01 program project FOA or related NIGMS program announcements. The official announcement page was provided through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PAR-13-280.html, and the contact point for technical access or linking issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

In practical terms, the FOA is aimed at institutions that can assemble a cohesive team and a set of interdependent research projects centered on a single, high-impact biological problem. The defining feature is integration: the program should be designed so that the projects inform and strengthen each other through shared goals, coordinated planning, and scientific synergy, making the program clearly more compelling than a collection of stand-alone R01-style efforts.

Frequently Asked Questions (FAQs)

What is the "Support of NIGMS Program Project Grants (P01)" opportunity (PAR-13-280)?

PAR-13-280 is a National Institutes of Health (NIH) funding announcement from the National Institute of General Medical Sciences (NIGMS). It invites applications for Program Project (P01) grants that address major questions in fundamental biological research through large, coordinated, multi-investigator research programs.

Which NIH institute is sponsoring this funding announcement?

The sponsoring institute is the National Institute of General Medical Sciences (NIGMS), part of the NIH.

What is the main purpose of an NIGMS P01 Program Project Grant under this FOA?

The purpose is to support tightly integrated, interactive research programs where multiple investigators and multiple interdependent projects work together on a shared, significant biological problem that fits the NIGMS mission. The program is expected to produce scientific advantages that would be difficult to achieve through separate, stand-alone awards.

What kind of research does this opportunity emphasize?

It emphasizes fundamental biological research aligned with NIGMS priorities in foundational biomedical science and research training, within the broad NIH health and biomedical research area.

What makes a strong P01 application for this announcement?

Based on the description provided, a strong application is centered on a single, high-impact biological problem and is designed for real scientific integration across projects. NIGMS is looking for a program where collaboration, shared approaches, complementary expertise, coordinated planning, and cross-project insights make the whole program clearly stronger than the sum of its parts.

Is this FOA intended to fund several related but independent projects?

No. The announcement highlights that NIGMS is not looking for a set of separate projects that simply happen to be related. The focus is on a coordinated program with meaningful interdependence and synergy among projects and investigators.

What is the funding mechanism and category?

The mechanism is a grant using the Program Project (P01) structure. The opportunity is described as falling under the discretionary category.

Are there cost sharing or matching requirements?

No cost sharing or matching requirement is listed in the provided information. Applicants are not required to provide non-federal matching funds as a condition of eligibility, although standard NIH budgeting and cost principles still apply.

What CFDA numbers are associated with this opportunity?

This opportunity is associated with CFDA 93.172 (Human Genome Research) and CFDA 93.859 (Biomedical Research and Research Training).

Which organizations are eligible to apply?

Eligibility is broad across U.S.-based organizations and public entities. Eligible applicants include:

  • Public and state-controlled institutions of higher education
  • Private institutions of higher education
  • Nonprofit organizations (including 501(c)(3) and certain nonprofits without 501(c)(3) status, other than institutions of higher education)
  • For-profit organizations (other than small businesses)
  • Small businesses
  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public housing authorities and Indian housing authorities
  • Federally recognized Native American tribal governments
  • Tribal organizations (including those not federally recognized)
  • U.S. territories or possessions
  • Eligible federal agencies
  • Faith-based or community-based organizations
  • Regional organizations

Are minority-serving institutions included as eligible applicants?

Yes. The announcement explicitly recognizes eligibility for several minority-serving institutions and related entities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs).

Can a foreign (non-U.S.) institution apply as the applicant organization?

No. Non-domestic (non-U.S.) entities are not eligible to apply as the main applicant organization under the provided eligibility limits.

Can a non-U.S. component of a U.S. organization apply as the applicant component?

No. Non-domestic components of U.S. organizations are not eligible to apply as applicant components under this FOA.

Are foreign collaborators or foreign work allowed at all?

Yes, in a limited way. The FOA allows "foreign components" as defined under the NIH Grants Policy Statement. This typically means a U.S. applicant may include certain foreign work or foreign collaborators when well-justified and consistent with NIH policy, even though a foreign institution cannot be the primary applicant.

When was this funding opportunity posted?

The opportunity was posted and created on July 19, 2013.

What was the closing date for applications under PAR-13-280?

The original and final listed closing date is September 7, 2016.

Is PAR-13-280 still open for new applications?

No. The archive date is October 8, 2016, which indicates the FOA is no longer active for new submissions under that specific announcement.

What should applicants do if they want a current P01 opportunity related to NIGMS?

The provided information indicates that applicants would typically search NIH and NIGMS listings for the most recent P01 program project FOA or related NIGMS program announcements, since PAR-13-280 has been archived.

Where can the official FOA page be found?

The official NIH Grants Guide page provided is: http://grants.nih.gov/grants/guide/pa-files/PAR-13-280.html

Who is the contact for technical access or linking issues related to the FOA page?

The contact point listed for technical access or linking issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

What is the defining feature of the research program NIGMS wants to support here?

Integration and synergy. The program should be structured so projects inform and strengthen each other through shared goals, coordinated planning, integrated experimental strategies, and cross-project insights, creating clear advantages over separate R01-style efforts.

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