Opportunity Information: Apply for CDC RFA PS10 10106

  • The Centers for Disease Control and Prevention in the health sector is offering a public funding opportunity titled "Supporting the National Blood Transfusion Service in the Implementation and Expansion of Blood Safety Activities in the Republic of Zambia under the President s Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067 Global AIDS.
  • This funding opportunity was created on Jan 6, 2010 and posted on Jan 6, 2010.
  • Applicants must submit their applications by Mar 8, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $22,600,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
  • The ZNBTS is a statutory board under the MOH and the only institution mandated to ensure efficient and effective implementation of the national blood safety strategy. Since August 2004, ZNBTS has been implementing the PEPFAR funded Rapid Strengthening of Blood Transfusion Services Program , a national program aimed at scaling up safe blood transfusion services to ensure efficient, effective, equitable, and affordable access to safe blood and blood products throughout the country. The project is supported by PEPFAR, with a five year grant scheduled to end in March 2010. In Zambia, screening of blood for HIV, prior to transfusion, started in 1986 with technical and financial support from the World Health Organization (WHO). Under this program, a total of 33 blood screening laboratories were established, where blood was screened for HIV prior to transfusion into patients. However, these centers primarily focused on HIV screening only, without testing for the other transfusion transmissible infections (TTIs). Since 1988, Zambia identified the need and commenced the implementation of a comprehensive blood safety program, founded on the WHO guidelines for the establishment of national blood transfusion services. This program places an emphasis on 1) Promotion of dependency on regular repeating VNRD from low risk population groups, particularly regular repeating donors 2) Development and application of stricter criteria for selection of blood donors 3) Mandatory laboratory screening of blood for HIV, Hepatitis and Syphilis 4) Application of appropriate technologies, methods and standards for laboratory screening and processing of blood 5) Promotion of appropriate methods for clinical use of blood, so as to reduce blood transfusions to a bare minimum 6) Development of appropriate national policy and legal framework to guide blood transfusion practices and 7) Establishment of appropriate nationally coordinated blood transfusion system, with strong government support. Implementation of this strategy has been significantly accelerated by the commencement of PEPFAR support, which has already started making a significant positive impact on blood safety in Zambia. Achievements since the commencement of PEPFAR support include Increasing the number of blood units collected annually from 38,477 in 2004 to 90,049 at the end of March 2009 Reduction in HIV prevalence among first time blood donors from 6.0 in 2004 to 3.8 in 2009 ZNBTS has successfully carried out an interim reorganization and streamlining of functions. This has led to stronger and more effective national coordination, reduction in the number of facilities involved in blood collection and laboratory screening of blood, and redefinition and allocation of functions at all the levels of the blood transfusion system Systems strengthening in infrastructure and equipment. Various protocols and standard operating procedures have been developed and/or updated further enhancing blood safety program at every stage of the blood transfusion process Enhancement of the NBTS technical and managerial capacity to ensure strong national and international leadership Strengthen quality assurance with the introduction of external quality assessment schemes for all the blood transfusion centers, on HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV). The NBTS is the only eligible applicant that can apply for this funding opportunity due to their unique position as the official national service provider and policy advisor for safe blood collection and transfusion practices under the MOH. It is also the only entity in the Republic of Zambia that provides blood transfusion services and is capable of executing the objectives of this agreement, as exemplified by their quality of services, long history of leading this technical domain within the country working with international donors such as PEPFAR. Supporting the NBTS is furthermore consi
Apply for CDC RFA PS10 10106

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Opportunity Summary:

This funding opportunity (CDC RFA PS10-10106) is a PEPFAR-supported cooperative agreement from the U.S. Centers for Disease Control and Prevention focused on one central goal: strengthening Zambia's National Blood Transfusion Service (NBTS) so it can reliably provide health facilities across the country with a safe and adequate supply of blood and blood products. In practical terms, the grant is designed to keep building and expanding the systems that make blood transfusion safer, more consistent, and more nationally coordinated, with a strong emphasis on preventing HIV and other transfusion-transmissible infections from being passed to patients through blood.

The award is categorized as a discretionary health grant and uses a cooperative agreement mechanism, meaning CDC would typically be more actively involved than in a standard grant by providing substantial programmatic input and oversight. The estimated total funding level listed is USD 22.6 million, and the announcement anticipated a single award. There is no cost sharing or matching requirement, which signals that the program was intended to be fully supported through the award rather than requiring the applicant to contribute additional funds as a condition of participation. The opportunity was posted on January 6, 2010, with an original and final closing date of March 8, 2010, and it was later archived on April 7, 2010.

Eligibility is highly restricted. The opportunity states that the only eligible applicant is the Zambia National Blood Transfusion Service, described as a statutory board under the Ministry of Health and the sole institution mandated to implement the national blood safety strategy. The justification for limiting eligibility is that NBTS occupies a unique legal and operational role: it is the national service provider and policy advisor for safe blood collection and transfusion practice, and it is presented as the only entity in Zambia capable of executing the agreement's objectives at the required national scale. This restriction is also tied to the fact that NBTS had already been implementing a major PEPFAR-funded national blood program since August 2004, known as the Rapid Strengthening of Blood Transfusion Services Program, with a five-year grant scheduled to end in March 2010. In other words, this announcement functions as a continuation and expansion pathway to preserve gains and push further improvements rather than allowing momentum to drop at the end of the prior funding cycle.

The background included in the announcement explains why the program priorities extend beyond HIV alone. Zambia began screening blood for HIV prior to transfusion in 1986, supported by WHO, and established 33 screening laboratories. However, those earlier efforts were largely limited to HIV screening and did not consistently cover the broader set of transfusion-transmissible infections (TTIs) that also pose serious risks to patients. Starting in 1988, Zambia moved toward a comprehensive blood safety program aligned with WHO guidance for national blood transfusion services, emphasizing that safe transfusion requires an entire system: safe donors, strong testing, careful processing, appropriate clinical use, and supportive policy and governance.

The announcement outlines the core pillars of the national strategy that this cooperative agreement is meant to strengthen and expand. These include promoting reliance on regular, repeat voluntary non-remunerated blood donors from lower-risk population groups; applying stricter donor selection criteria; ensuring mandatory laboratory screening not only for HIV but also for hepatitis and syphilis; using appropriate technologies, methods, and standards in screening and processing; promoting appropriate clinical use of blood so transfusions are used only when medically necessary; strengthening national policy and legal frameworks; and maintaining a nationally coordinated blood transfusion system with strong government support. Taken together, these priorities show that the program is not just about collecting more blood, but about making the entire transfusion chain safer and more efficient, from recruitment and selection of donors through to testing, processing, distribution, and clinical use.

The opportunity also highlights concrete results achieved during the earlier PEPFAR-supported period, presenting them as evidence that further investment is worthwhile. It reports that annual blood unit collection increased from 38,477 units in 2004 to 90,049 by the end of March 2009, which reflects a major scale-up in supply. It also notes a reduction in HIV prevalence among first-time blood donors from 6.0% in 2004 to 3.8% in 2009, suggesting improved donor selection, safer donor pools, and stronger prevention and recruitment approaches. On the systems side, it describes an interim reorganization and streamlining of functions that strengthened national coordination, reduced the number of facilities involved in collection and screening, and clarified roles across levels of the transfusion system. Additional achievements include investments in infrastructure and equipment, development and updating of protocols and standard operating procedures across the transfusion process, and efforts to build technical and managerial capacity so NBTS can provide stronger leadership both nationally and in line with international expectations.

Quality assurance is singled out as a major area of progress and a likely continuing focus under the new award. The announcement notes the introduction of external quality assessment schemes for transfusion centers covering HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV). This matters because even when testing is officially required, the reliability of results depends on consistent quality systems, proficiency testing, equipment maintenance, standardized procedures, documentation, and corrective action when problems appear. External quality assessment is a key tool for making sure testing accuracy is not just assumed but continuously verified across sites.

In summary, this CDC/PEPFAR cooperative agreement was built to ensure Zambia could sustain and expand a national blood safety system that had already shown measurable gains in both supply and safety. It supports NBTS as the nationally mandated institution to keep scaling collection from safer donor populations, expand and standardize screening for multiple infections, strengthen laboratory and processing standards, improve governance and coordination, and deepen quality assurance so blood and blood products delivered to Zambian health facilities are both adequate in quantity and as safe as possible.

Frequently Asked Questions (FAQs)

What is CDC RFA PS10-10106?

CDC RFA PS10-10106 is a PEPFAR-supported funding opportunity from the U.S. Centers for Disease Control and Prevention (CDC) to strengthen Zambia's National Blood Transfusion Service (NBTS) so it can reliably provide health facilities nationwide with a safe and adequate supply of blood and blood products.

What is the central goal of this cooperative agreement?

The central goal is to strengthen Zambia's National Blood Transfusion Service so it can consistently deliver a nationally coordinated blood supply that is both sufficient in quantity and safe, with a strong emphasis on preventing HIV and other transfusion-transmissible infections from being passed to patients through blood.

What type of funding mechanism is used?

This opportunity uses a cooperative agreement mechanism. That generally means CDC would be more actively involved than under a standard grant, providing substantial programmatic input and oversight as the work is carried out.

How is the award categorized?

The award is categorized as a discretionary health grant.

How much funding was estimated for this opportunity?

The estimated total funding level listed is USD 22.6 million.

How many awards were anticipated?

The announcement anticipated a single award.

Is cost sharing or matching required?

No. The opportunity states there is no cost sharing or matching requirement.

Who is eligible to apply?

Eligibility is highly restricted. The only eligible applicant named in the opportunity is the Zambia National Blood Transfusion Service (NBTS), described as a statutory board under the Ministry of Health and the sole institution mandated to implement the national blood safety strategy.

Why was eligibility limited only to NBTS?

The opportunity justifies the restriction by stating that NBTS has a unique legal and operational role as the national service provider and policy advisor for safe blood collection and transfusion practice, and that it is the only entity in Zambia capable of executing the agreement's objectives at the required national scale.

How does this opportunity relate to prior PEPFAR funding in Zambia?

This announcement is tied to NBTS having implemented a major PEPFAR-funded national blood program since August 2004 (the Rapid Strengthening of Blood Transfusion Services Program), with a five-year grant scheduled to end in March 2010. The opportunity is presented as a continuation and expansion pathway to sustain gains and push further improvements beyond that earlier funding cycle.

What are the key system areas the grant is meant to strengthen?

The announcement emphasizes strengthening and expanding the systems that make transfusion safer and more nationally coordinated, including donor recruitment and selection, mandatory infection screening, appropriate testing and processing standards, distribution and coordination, appropriate clinical use of blood, and supportive national policy, legal frameworks, and governance.

Is the program only focused on HIV?

No. While preventing HIV transmission through transfusion is a strong emphasis, the background explains that earlier efforts in Zambia were often limited to HIV screening and did not consistently cover the broader set of transfusion-transmissible infections (TTIs). The national strategy highlighted in the announcement includes screening for hepatitis and syphilis in addition to HIV.

What donor strategy is promoted under the national approach described?

The strategy promotes reliance on regular, repeat voluntary non-remunerated blood donors from lower-risk population groups, along with stricter donor selection criteria.

What infections are specifically mentioned for mandatory laboratory screening?

The announcement specifies mandatory screening for HIV, hepatitis, and syphilis. It also discusses quality assessment schemes covering HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV).

What does the opportunity say about laboratory and processing standards?

It emphasizes using appropriate technologies, methods, and standards in screening and processing, supported by protocols and standard operating procedures across the transfusion process.

Does the opportunity address how blood should be used in health facilities?

Yes. The national strategy described includes promoting appropriate clinical use of blood so transfusions are used only when medically necessary.

What role do policy and governance play in the described strategy?

The announcement includes strengthening national policy and legal frameworks, and maintaining a nationally coordinated blood transfusion system with strong government support as core elements of the strategy.

What results were reported from the earlier PEPFAR-supported period?

The announcement reports that annual blood unit collection increased from 38,477 units in 2004 to 90,049 by the end of March 2009. It also reports a reduction in HIV prevalence among first-time blood donors from 6.0% in 2004 to 3.8% in 2009.

What systems improvements were highlighted as achievements under earlier support?

Highlighted achievements include interim reorganization and streamlining of functions to strengthen national coordination, reducing the number of facilities involved in collection and screening, clarifying roles across levels of the transfusion system, investing in infrastructure and equipment, developing and updating protocols and standard operating procedures, and building technical and managerial capacity within NBTS.

What is external quality assessment and why is it emphasized?

The announcement highlights the introduction of external quality assessment schemes for transfusion centers (covering HIV, HBV, and HCV). It emphasizes this because reliable testing depends on consistent quality systems, including standardized procedures, proficiency checks, documentation, equipment maintenance, and corrective actions when issues are identified.

When was the opportunity posted and when did it close?

The opportunity was posted on January 6, 2010. The original and final closing date listed was March 8, 2010.

What does it mean that the opportunity was archived?

The announcement was later archived on April 7, 2010, indicating it is no longer an active open funding opportunity under that posting.

What geographic scope does the program target?

The program targets Zambia at a national scale, aiming to supply health facilities across the country through a nationally coordinated blood transfusion system led by NBTS.

What is the practical focus of the work described in the announcement?

In practical terms, the focus is on continuing to build and expand the end-to-end blood safety and supply system: recruiting safer repeat voluntary donors, improving donor selection, ensuring mandatory screening for multiple infections, strengthening processing and standards, improving coordination and distribution, promoting appropriate clinical use, and reinforcing quality assurance so results are consistent across sites.

Why does the announcement stress national coordination?

Because safe transfusion is described as a full system (donors, testing, processing, clinical use, and governance), and the opportunity positions NBTS as the nationally mandated institution to coordinate these functions consistently across Zambia.

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