Opportunity Information: Apply for PA 13 210

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Symptom Management in HIV Infected Individuals with Comorbid Conditions (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research.
  • This funding opportunity was created on Apr 24, 2013 and posted on Apr 24, 2013.
  • Applicants must submit their applications by Sep 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Independent school districts County governments City or township governments For profit organizations other than small businesses State governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Public housing authorities/Indian housing authorities Small businesses Public and State controlled institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Symptom Management in HIV Infected Individuals with Comorbid Conditions (R01) opportunity (Funding Opportunity Number PA 13-210) was a National Institutes of Health (NIH) discretionary grant announcement aimed at supporting research on symptom management for people living with HIV who also experience HIV-Associated Non-AIDS (HANA) conditions. The core emphasis was on building the evidence base for interventions that help identify, monitor, and manage symptoms tied to these non-AIDS comorbidities, with particular attention to functional capacity, frailty, and the broader goal of improving resilience and self-care. In practical terms, the announcement centered on helping individuals with HIV maintain or regain day-to-day functioning, reduce symptom burden linked to aging and chronic comorbid disease, and strengthen the skills or supports needed to manage health challenges over time.

The research scope highlighted three main intervention-oriented pathways: development of new interventions, adaptation of existing interventions to the HIV/HANA context, and rigorous testing of interventions to determine whether they work and under what circumstances. The target problems were symptoms and symptom clusters commonly experienced in the context of HANA conditions, especially those that contribute to declines in functional status or lead to frailty. The opportunity also stressed resilience, framed as increased self-care capacity, which can include behaviors and strategies that help people recognize symptoms early, respond effectively, adhere to care plans, navigate healthcare systems, and sustain lifestyle changes that preserve functioning. While the announcement language is broad, the clear expectation was that applications would go beyond describing symptom prevalence and instead focus on actionable, measurable intervention strategies that can be evaluated in well-designed studies.

Administratively, this was an NIH grant using the R01 mechanism, which typically supports mature, hypothesis-driven research projects with a defined plan for implementation and evaluation. The activity category was listed under Education/Health, with a CFDA number of 93.361 (Nursing Research), signaling a strong fit for interdisciplinary teams that may include nursing science, behavioral and social science, clinical research, geriatrics, rehabilitation, implementation science, and related fields. The posting and creation dates were April 24, 2013, and the opportunity was open until the original and current closing date of September 7, 2016, after which it was archived on October 8, 2016. There was no cost sharing or matching requirement, meaning applicants were not required to contribute non-federal funds as a condition of receiving the award.

Eligibility was expansive across public, private, nonprofit, and for-profit sectors. Eligible applicants included state, county, city or township governments; independent school districts; special district governments; public housing authorities/Indian housing authorities; small businesses; for-profit organizations other than small businesses; private and public/state-controlled institutions of higher education; and nonprofits both with and without 501(c)(3) status (with the noted exception category for certain nonprofits relative to higher education). The announcement also explicitly included a wide range of mission-driven and underrepresented-serving institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations and eligible federal agencies. U.S. territories or possessions and regional organizations were also listed among eligible entities.

At the same time, the announcement drew clear boundaries regarding non-U.S. participation. Non-domestic (non-U.S.) entities (foreign institutions) were not eligible to apply as primary applicants. However, non-domestic components of U.S. organizations were eligible, and foreign components were allowed as defined in the NIH Grants Policy Statement. This distinction matters for research teams that may want to include international collaborators or study populations, since it permits certain international involvement without allowing a foreign institution to be the applicant organization.

For access and support, NIH provided an additional information link to the full announcement at http://grants.nih.gov/grants/guide/pa-files/PA-13-210.html. The contact guidance in the source data focuses on technical help: applicants who could not access the announcement electronically or who had linking issues were directed to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV. Overall, PA 13-210 was designed to move the field toward practical, tested approaches for symptom identification and management in HIV populations facing non-AIDS comorbidities, with special emphasis on preserving function, addressing frailty, and strengthening resilience through self-care.

Frequently Asked Questions (FAQs)

What is the "Symptom Management in HIV Infected Individuals with Comorbid Conditions (R01)" opportunity?

It is an NIH discretionary grant announcement focused on supporting research that improves symptom management for people living with HIV who also have HIV-Associated Non-AIDS (HANA) conditions. The emphasis is on building evidence for interventions that help identify, monitor, and manage symptoms tied to non-AIDS comorbidities.

What is the Funding Opportunity Number (FON) for this announcement?

The Funding Opportunity Number is PA 13-210.

What type of grant mechanism does this opportunity use?

This opportunity uses the NIH R01 mechanism, which typically supports mature, hypothesis-driven research projects with a defined plan for implementation and evaluation.

What is the main goal of the research supported by this opportunity?

The main goal is to move beyond describing symptom prevalence and instead support actionable, measurable intervention strategies that can be evaluated in well-designed studies. The overall aims include reducing symptom burden, preserving or regaining day-to-day functioning, addressing frailty, and improving resilience through self-care capacity.

What kinds of health issues are the focus of this announcement?

The focus is on symptoms and symptom clusters experienced in the context of HIV-Associated Non-AIDS (HANA) conditions, especially symptoms that contribute to declines in functional status or lead to frailty.

What does the announcement emphasize regarding functional status and frailty?

It places particular attention on maintaining or improving functional capacity and addressing frailty, with the broader goal of helping people living with HIV sustain day-to-day functioning as they face aging and chronic comorbid disease.

How does the announcement define or frame "resilience"?

Resilience is framed as increased self-care capacity. This can include behaviors and strategies that help people recognize symptoms early, respond effectively, adhere to care plans, navigate healthcare systems, and sustain lifestyle changes that preserve functioning.

What types of intervention research pathways are highlighted?

The scope highlights three intervention-oriented pathways: (1) development of new interventions, (2) adaptation of existing interventions to the HIV/HANA context, and (3) rigorous testing of interventions to determine whether they work and under what circumstances.

Is this opportunity intended for descriptive studies of symptom prevalence?

The expectation is that applications go beyond describing symptom prevalence and instead focus on intervention strategies that are actionable, measurable, and evaluable.

What is the CFDA number associated with this opportunity?

The CFDA number listed is 93.361 (Nursing Research).

What activity category is this opportunity listed under?

The activity category is listed under Education/Health.

Does the CFDA listing suggest particular disciplines or team compositions?

Yes. The Nursing Research CFDA listing signals a strong fit for interdisciplinary teams that may include nursing science, behavioral and social science, clinical research, geriatrics, rehabilitation, implementation science, and related fields.

When was this opportunity posted and created?

The posting date and creation date are both April 24, 2013.

What was the closing date for applications?

The original and current closing date was September 7, 2016.

Is this funding opportunity still open?

No. It was archived on October 8, 2016, after the closing date.

Is there a cost sharing or matching requirement?

No. There was no cost sharing or matching requirement, meaning applicants were not required to contribute non-federal funds as a condition of receiving the award.

What types of organizations were eligible to apply?

Eligibility was expansive across public, private, nonprofit, and for-profit sectors. Eligible applicants included various levels of government (state, county, city or township), independent school districts, special district governments, public housing authorities/Indian housing authorities, small businesses, for-profit organizations other than small businesses, private and public/state-controlled institutions of higher education, and nonprofits with or without 501(c)(3) status (with a noted exception category related to certain nonprofits and higher education).

Were underrepresented-serving and mission-driven institutions explicitly included?

Yes. The announcement explicitly included organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also included faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, and regional organizations.

Can non-U.S. (foreign) institutions apply as the primary applicant?

No. Non-domestic (non-U.S.) entities (foreign institutions) were not eligible to apply as primary applicants.

Are any international or non-U.S. components allowed to participate?

Yes. Non-domestic components of U.S. organizations were eligible, and foreign components were allowed as defined in the NIH Grants Policy Statement. This allows certain international involvement without permitting a foreign institution to be the applicant organization.

Where can applicants find the full announcement text?

The full announcement was available at http://grants.nih.gov/grants/guide/pa-files/PA-13-210.html.

Who should be contacted for technical issues accessing the announcement?

Applicants who could not access the announcement electronically or who had linking issues were directed to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

What is the overall practical impact this opportunity aimed to achieve?

It aimed to strengthen the evidence base for practical, tested approaches to symptom identification and management in HIV populations facing non-AIDS comorbidities, with special emphasis on preserving function, reducing symptom burden linked to aging and chronic comorbid disease, addressing frailty, and strengthening resilience through self-care.

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