Opportunity Information: Apply for PA 13 286
Apply for PA 13 286
- The National Institutes of Health in the education food and nutrition health sector is offering a public funding opportunity titled "Systemic Amyloidosis Basic, Translational, and Clinical Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Jul 26, 2013 and posted on Jul 26, 2013.
- Applicants must submit their applications by Sep 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) State governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses City or township governments Special district governments Native American tribal governments (Federally recognized) Independent school districts Small businesses Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Systemic Amyloidosis Basic, Translational, and Clinical Research (R01) opportunity (Funding Opportunity Number PA-13-286) is a National Institutes of Health (NIH) discretionary grant program that supported research projects aimed at improving the understanding, diagnosis, and treatment of systemic amyloidosis. It used the NIH R01 mechanism, which is the standard, investigator-initiated research project grant format designed for well-developed, hypothesis-driven studies that can span basic science through clinical investigation. In practical terms, this opportunity was meant to encourage proposals that move the field forward at multiple levels, including foundational biology of amyloid diseases, translational work that connects lab discoveries to patient-focused applications, and clinical research that improves how these conditions are detected, monitored, and treated.
This funding announcement sat within NIH activity categories tied to health research, and it was associated with multiple CFDA program areas, including several cancer-related research codes (93.393, 93.394, 93.395, 93.396, 93.399), as well as NIH programs focused on diabetes, digestive, and kidney diseases (93.847) and aging research (93.866). That mix signals that systemic amyloidosis was treated as a cross-cutting biomedical problem with relevance across organ systems and disease areas rather than being confined to a single institute or specialty. Amyloidosis can affect the heart, kidneys, nerves, gastrointestinal tract, and other organs, and it often intersects with hematologic disorders and age-related biology, so the broad program alignment reflects how NIH positioned the topic.
A notable feature of the announcement is that it did not require cost sharing or matching, meaning applicants were not expected to provide non-federal matching funds as a condition of receiving an award. This is typical for many NIH research grants and helps keep the focus on scientific merit and feasibility rather than an applicant’s ability to contribute additional dollars.
Eligibility was very broad and included many types of U.S. and non-U.S. organizations. Domestic eligible applicants included federal, state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; and private institutions of higher education. It also allowed nonprofit organizations both with and without 501(c)(3) status (so long as they met the relevant NIH criteria), public housing authorities/Indian housing authorities, and a wide range of for-profit entities (other than small businesses) as well as small businesses themselves. Beyond those categories, NIH explicitly listed additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American, Native American, and Pacific Islander-serving institutions (AANAPISIs), along with faith-based and community-based organizations and regional organizations. Importantly, foreign participation was permitted: non-U.S. organizations and foreign institutions could apply, non-U.S. components of U.S. organizations were eligible, and foreign components were allowed consistent with the NIH Grants Policy Statement. Taken together, the eligibility language reflects NIH’s intent to attract the strongest science wherever it is conducted and to encourage participation across institution types, including those that serve historically underrepresented communities.
From an administrative standpoint, the opportunity was posted and created on July 26, 2013. The original and current closing date were both September 7, 2016, and the archive date was October 8, 2016, indicating the announcement is no longer active for new submissions under that specific notice. Applicants looking for the full historical announcement and requirements were directed to the NIH Grants Guide link (http://grants.nih.gov/grants/guide/pa-files/PA-13-286.html). For technical issues accessing or linking to the announcement, NIH provided support through the NIH Office of Extramural Research (OER) webmaster contact (FBOWebmaster@OD.NIH.GOV).
Overall, PA-13-286 functioned as a targeted NIH R01 research solicitation centered on systemic amyloidosis, emphasizing work that could range from mechanistic discovery to translational development and clinical evaluation, while keeping eligibility open to a wide range of domestic and international research performers and not imposing a matching requirement.
FAQs: Systemic Amyloidosis Basic, Translational, and Clinical Research (R01) (PA-13-286)
What is PA-13-286?
PA-13-286 is the Funding Opportunity Number for the National Institutes of Health (NIH) discretionary grant opportunity titled Systemic Amyloidosis Basic, Translational, and Clinical Research (R01). It supported research projects aimed at improving the understanding, diagnosis, and treatment of systemic amyloidosis.
What type of grant mechanism did this opportunity use?
This opportunity used the NIH R01 mechanism. An R01 is NIH's standard, investigator-initiated research project grant format and is generally intended for well-developed, hypothesis-driven studies that can range from basic science through clinical investigation.
What kinds of research were encouraged under PA-13-286?
The announcement was meant to encourage proposals that move the systemic amyloidosis field forward at multiple levels, including:
- Basic research on the foundational biology of amyloid diseases
- Translational research connecting laboratory discoveries to patient-focused applications
- Clinical research improving how systemic amyloidosis is detected, monitored, and treated
Was this opportunity focused on a single disease area or institute?
No. The program alignment signals that NIH treated systemic amyloidosis as a cross-cutting biomedical problem with relevance across organ systems and disease areas rather than being confined to a single specialty.
Why is systemic amyloidosis considered cross-cutting in NIH program terms?
Systemic amyloidosis can affect multiple organs (including the heart, kidneys, nerves, gastrointestinal tract, and others) and can intersect with hematologic disorders and age-related biology. The broad program association reflects that multi-organ and multi-discipline relevance.
Which CFDA program areas were associated with this opportunity?
This funding announcement was associated with multiple CFDA program areas, including several cancer-related research codes (93.393, 93.394, 93.395, 93.396, 93.399), as well as NIH programs focused on diabetes, digestive, and kidney diseases (93.847) and aging research (93.866).
Did the grant require cost sharing or matching funds?
No. The announcement did not require cost sharing or matching. Applicants were not expected to provide non-federal matching funds as a condition of receiving an award.
Who was eligible to apply within the United States?
Eligibility was broad and included many types of domestic organizations, including:
- Federal, state, county, city/township, and special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations with or without 501(c)(3) status (consistent with NIH criteria)
- Public housing authorities/Indian housing authorities
- For-profit entities (other than small businesses)
- Small businesses
Were minority-serving institutions and community-based organizations eligible?
Yes. NIH explicitly listed additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American, Native American, and Pacific Islander-serving institutions (AANAPISIs). It also included faith-based and community-based organizations, as well as regional organizations.
Could foreign (non-U.S.) organizations apply?
Yes. Foreign participation was permitted. Non-U.S. organizations and foreign institutions could apply, non-U.S. components of U.S. organizations were eligible, and foreign components were allowed consistent with the NIH Grants Policy Statement.
Are non-U.S. components of U.S. organizations eligible under this announcement?
Yes. The eligibility language stated that non-U.S. components of U.S. organizations were eligible.
Was this funding opportunity active for new applications after 2016?
No. The original and current closing date were both September 7, 2016, and the archive date was October 8, 2016. This indicates the announcement is no longer active for new submissions under that specific notice.
When was PA-13-286 posted?
The opportunity was posted and created on July 26, 2013.
Where can someone find the full historical announcement for PA-13-286?
The full historical announcement and requirements were available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-13-286.html.
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues, NIH provided support through the NIH Office of Extramural Research (OER) webmaster contact: FBOWebmaster@OD.NIH.GOV.
How did NIH frame the overall purpose of PA-13-286?
Overall, PA-13-286 functioned as a targeted NIH R01 research solicitation centered on systemic amyloidosis. It emphasized work spanning mechanistic discovery, translational development, and clinical evaluation, kept eligibility open to a wide range of domestic and international research performers, and did not impose a matching requirement.
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