Opportunity Information: Apply for RFA AI 14 064
Apply for RFA AI 14 064
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Systems Biology and Antibacterial Resistance (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Jan 27, 2015 and posted on Jan 27, 2015.
- Applicants must submit their applications by Jul 9, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $8,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Special district governments For profit organizations other than small businesses City or township governments Small businesses Public housing authorities/Indian housing authorities State governments Native American tribal governments (Federally recognized) Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity titled "Systems Biology and Antibacterial Resistance (U01)" (Funding Opportunity Number RFA-AI-14-064) is a National Institutes of Health (NIH) cooperative agreement meant to support research that tackles antibacterial resistance using a systems biology framework. The core idea is to go beyond studying single genes or isolated pathways and instead map and understand the broader molecular interaction networks that connect a drug-resistant bacterial pathogen with its human (or host) biology. Projects are expected to integrate multiple disciplines and data types to explain how resistance is established, maintained, or altered, and how the host responds during infection or during treatment of infections caused by antibacterial-resistant bacteria.
The scientific scope is specifically centered on bacterial pathogens that already have established antibacterial resistance. The FOA is interested in research that can describe and model pathogen-host interaction networks, including how those networks shift under antibiotic pressure or during clinical treatment. This can include work that combines computational modeling, network analysis, genomics, transcriptomics, proteomics, metabolomics, high-throughput screening, and other systems-level approaches, as long as the central objective remains understanding the interaction circuitry between pathogen and host in the context of resistance or treatment response. A key limitation is that applications focused on drug-resistant tuberculosis are explicitly not supported under this announcement, so proposals centered on Mycobacterium tuberculosis resistance would fall outside the allowed scope.
Mechanistically, the funding instrument is a U01 cooperative agreement, which generally indicates substantial scientific or programmatic involvement by NIH staff compared with a standard research project grant. In practical terms, this often means awardees may be expected to coordinate with NIH program staff on milestones, data-sharing expectations, collaborative efforts, and progress oversight, consistent with cooperative agreement structures. The activity category is health, and the relevant CFDA listings are 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research), aligning the program squarely with infectious disease and microbial pathogenesis priorities.
Financially, NIH estimated a total of $8,000,000 to support the program, with an expectation of making about five awards. The award ceiling is listed as $2,000,000, signaling that individual projects could be sizable and likely designed to support multi-component, interdisciplinary systems biology work. There is no cost sharing or matching requirement, which lowers administrative and budgetary barriers for applicants and is consistent with many NIH opportunities.
Eligibility is broad and includes many types of organizations that typically participate in federal biomedical research. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education in those nonprofit categories), for-profit organizations (including small businesses and other than small businesses), and a wide range of government entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The announcement also extends eligibility to tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments), as well as tribally controlled colleges and universities (TCCUs).
The FOA explicitly notes additional eligible applicant categories that commonly reflect NIH inclusion goals and federal eligibility structures. These include historically Black colleges and universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander serving institutions (AANAPISIs). Faith-based or community-based organizations are also included where relevant. Notably, the eligibility list includes non-domestic (non-U.S.) entities (foreign organizations), U.S. territories or possessions, regional organizations, and eligible agencies of the federal government, indicating that NIH was open to a wide range of institutional settings capable of executing sophisticated systems biology research, potentially including international collaborations.
From an administrative timeline perspective, the FOA was posted and created on January 27, 2015. The original and current closing date was July 9, 2015, and the archive date was August 9, 2015, meaning the opportunity is now closed and archived, but the details remain useful for understanding NIH priorities and the structure of similar future announcements. The listing provides an additional information link to the full FOA on the NIH grants site (http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-064.html). For access issues or linking problems, the contact point given is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, this opportunity was designed to fund a small set of relatively high-budget, interdisciplinary projects that treat antibacterial resistance as a networked biological problem involving both pathogen and host, with an emphasis on systems-level measurement and modeling of interactions and treatment responses, while explicitly excluding drug-resistant tuberculosis as a topic area.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Systems Biology and Antibacterial Resistance (U01)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-AI-14-064.
Which agency is offering this opportunity?
This is a National Institutes of Health (NIH) funding opportunity.
What type of funding mechanism is it?
The award mechanism is a U01 cooperative agreement.
What does a U01 cooperative agreement generally imply?
A U01 cooperative agreement generally indicates substantial scientific or programmatic involvement by NIH staff compared with a standard research project grant. In practical terms, awardees may be expected to coordinate with NIH program staff on items such as milestones, data-sharing expectations, collaborative efforts, and progress oversight, consistent with cooperative agreement structures.
What is the main scientific focus of the program?
The program supports research to tackle antibacterial resistance using a systems biology framework. The central idea is to move beyond studying single genes or isolated pathways and instead map and understand broader molecular interaction networks that connect a drug-resistant bacterial pathogen with human/host biology.
What kinds of research questions are projects expected to address?
Projects are expected to integrate multiple disciplines and data types to explain how resistance is established, maintained, or altered, and how the host responds during infection or during treatment of infections caused by antibacterial-resistant bacteria.
Does the FOA focus on specific pathogens?
Yes. The scope is centered on bacterial pathogens that already have established antibacterial resistance, with an emphasis on understanding pathogen-host interaction networks in the context of resistance and treatment response.
What types of approaches or methods are encouraged?
The FOA is interested in work that can describe and model pathogen-host interaction networks, including how networks shift under antibiotic pressure or during clinical treatment. Approaches mentioned include (as long as the central objective remains systems-level understanding of pathogen-host interaction circuitry):
- Computational modeling
- Network analysis
- Genomics
- Transcriptomics
- Proteomics
- Metabolomics
- High-throughput screening
- Other systems-level approaches
Is drug-resistant tuberculosis (TB) within scope?
No. Applications focused on drug-resistant tuberculosis are explicitly not supported under this announcement. Proposals centered on Mycobacterium tuberculosis resistance fall outside the allowed scope.
What is the activity category?
The activity category is health.
What CFDA listings are associated with this program?
The CFDA listings are:
- 93.855 - Allergy and Infectious Diseases Research
- 93.856 - Microbiology and Infectious Diseases Research
How much total funding was NIH planning to commit to this program?
NIH estimated a total of $8,000,000 to support the program.
How many awards were expected?
The FOA stated an expectation of making about five awards.
What is the maximum award size (award ceiling)?
The award ceiling is listed as $2,000,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes many organization types typically involved in federal biomedical research, including:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofits (501(c)(3) and non-501(c)(3), excluding institutions of higher education in those nonprofit categories)
- For-profit organizations (including small businesses and other than small businesses)
- Government entities (state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities)
- Tribal governments (federally recognized)
- Tribal organizations (other than federally recognized tribal governments)
- Tribally controlled colleges and universities (TCCUs)
- Non-domestic (non-U.S.) entities (foreign organizations)
- U.S. territories or possessions
- Regional organizations
- Eligible agencies of the federal government
- Faith-based or community-based organizations (where relevant)
Are institutions serving underrepresented groups specifically mentioned as eligible?
Yes. The FOA explicitly includes categories such as:
- Historically Black colleges and universities (HBCUs)
- Hispanic-serving institutions
- Alaska Native and Native Hawaiian serving institutions
- Asian American Native American Pacific Islander serving institutions (AANAPISIs)
When was the FOA posted and created?
The FOA was posted and created on January 27, 2015.
What was the closing (due) date?
The original and current closing date was July 9, 2015.
Is this opportunity still open?
No. The archive date was August 9, 2015, so the opportunity is closed and archived.
Where can applicants find the full FOA details?
The full announcement is available on the NIH grants site at:
http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-064.html
Who should be contacted if there are access issues with the FOA link?
For access issues or linking problems, the contact point provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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