Opportunity Information: Apply for RFA DA 12 009
Apply for RFA DA 12 009
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Systems Biology Approaches in HIV/AIDS and Substance Use (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Apr 21, 2011 and posted on Apr 21, 2011.
- Applicants must submit their applications by Aug 17, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $650,000.00 in funding.
- Eligible applicants include: County governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses City or township governments Native American tribal governments (Federally recognized) State governments Independent school districts Special district governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
Systems Biology Approaches in HIV/AIDS and Substance Use (R01) (Funding Opportunity Number RFA-DA-12-009) was a discretionary National Institutes of Health (NIH) grant opportunity designed to support research projects that use systems biology to tackle important scientific questions at the intersection of HIV/AIDS and substance use. The central aim was to stimulate integrative, data-driven studies that move beyond single-gene or single-pathway explanations and instead look at how complex biological networks and interacting systems shape HIV disease processes, especially when influenced by drugs of abuse or other substance use. In practical terms, the FOA sought proposals that could combine multiple layers of biological information (for example, genomic, transcriptomic, proteomic, metabolomic, immunologic, neurologic, or clinical data) and use computational, mathematical, or network-based modeling to understand mechanisms, predict outcomes, and identify potential intervention points relevant to HIV infection, progression, comorbidities, and treatment response in the context of substance exposure.
The mechanism was an R01 (research project grant), meaning it was intended for substantial, hypothesis-driven or discovery-oriented projects led by an investigator team, often involving interdisciplinary collaboration between experimental biologists, clinicians, and computational or quantitative scientists. The activity fell under the broad Education and Health category and was associated with CFDA 93.279, Drug Abuse and Addiction Research Programs, reflecting the National Institute on Drug Abuse (NIDA) focus within NIH. The opportunity did not require cost sharing or matching, reducing barriers for applicants that might not have access to non-federal funds to supplement the project budget.
From a funding standpoint, the announcement listed an award ceiling of $650,000, indicating an upper bound on the amount that could be requested or awarded under the terms of the FOA (typically interpreted in line with NIH budget rules described in the full announcement). The FOA was posted and created on April 21, 2011, with an original and final application due date of August 17, 2011, and it was archived on September 17, 2011, meaning it was a time-limited call rather than an ongoing/open-ended program announcement.
Eligibility was broad and included many types of U.S. and non-U.S. institutions and organizations. Eligible applicants encompassed public and private institutions of higher education, nonprofits with or without 501(c)(3) status, small businesses, and for-profit entities (other than small businesses), along with various levels of government organizations such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly allowed applications from Native American tribal governments (federally recognized) and tribal organizations (including those not federally recognized), as well as tribally controlled colleges and universities. In addition, it listed a range of mission-relevant institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations. Notably, the FOA permitted non-domestic (non-U.S.) entities (foreign organizations), regional organizations, and U.S. territory or possession entities, and it allowed foreign components of U.S. organizations, signaling an openness to international collaboration when scientifically justified.
The sponsoring agency was NIH, and the full announcement (including specific scientific scope, review criteria, allowable costs, application instructions, and any special requirements tied to systems biology approaches) was made available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-12-009.html. For technical issues accessing or linking to the announcement, the contact provided was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the funding opportunity called?
The funding opportunity is titled Systems Biology Approaches in HIV/AIDS and Substance Use (R01), Funding Opportunity Number RFA-DA-12-009.
Which agency sponsored this opportunity?
The sponsoring agency was the National Institutes of Health (NIH), with the opportunity aligned with the National Institute on Drug Abuse (NIDA) focus area.
What type of grant mechanism was used?
This opportunity used the R01 (research project grant) mechanism, intended for substantial research projects led by an investigator team and often involving interdisciplinary collaboration.
What was the central aim of this FOA?
The central aim was to stimulate integrative, data-driven systems biology studies that address key scientific questions at the intersection of HIV/AIDS and substance use, moving beyond single-gene or single-pathway explanations to understand complex biological networks and interacting systems.
What kinds of research approaches were encouraged?
The FOA encouraged projects that combine multiple layers of biological information and apply computational, mathematical, or network-based modeling to understand mechanisms, predict outcomes, and identify potential intervention points related to HIV disease processes in the context of substance exposure.
What types of data could be integrated in proposed studies?
Examples of data layers mentioned include genomic, transcriptomic, proteomic, metabolomic, immunologic, neurologic, and clinical data.
What scientific areas or outcomes were the studies meant to inform?
The FOA described research intended to inform understanding of HIV infection, disease progression, comorbidities, and treatment response, specifically in contexts where these are influenced by drugs of abuse or other substance use.
What broad category did this activity fall under?
The activity was listed under the broad Education and Health category.
What CFDA program was associated with this opportunity?
This FOA was associated with CFDA 93.279, Drug Abuse and Addiction Research Programs.
Was cost sharing or matching required?
No. The opportunity explicitly stated that it did not require cost sharing or matching.
What was the award ceiling for this FOA?
The announcement listed an award ceiling of $650,000, indicating an upper bound on the amount that could be requested or awarded under the FOA terms (typically interpreted in line with NIH budget rules in the full announcement).
When was the FOA posted and created?
The FOA was posted and created on April 21, 2011.
What were the application due dates?
The FOA listed an original application due date of August 17, 2011, and the final application due date was also August 17, 2011.
Is this opportunity still open?
No. The FOA was archived on September 17, 2011, which indicates it was a time-limited call and is no longer active.
Who was eligible to apply?
Eligibility was described as broad and included many types of U.S. and non-U.S. institutions and organizations, spanning academic, nonprofit, business, and government entities.
Are U.S. colleges and universities eligible?
Yes. Eligible applicants included public and private institutions of higher education.
Are nonprofits eligible, and do they need 501(c)(3) status?
Yes. The FOA included nonprofits with or without 501(c)(3) status.
Are small businesses eligible?
Yes. Small businesses were included among eligible applicants.
Are for-profit entities eligible?
Yes. The FOA allowed for-profit entities (other than small businesses) as eligible applicants.
Are government entities eligible to apply?
Yes. The FOA listed multiple levels of government organizations as eligible, including state, county, and city or township governments, as well as special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The FOA explicitly allowed applications from Native American tribal governments (federally recognized) and tribal organizations, including those not federally recognized.
Are tribally controlled colleges and universities eligible?
Yes. Tribally controlled colleges and universities were listed among eligible applicants.
Did the FOA include eligibility for certain mission-relevant institution types?
Yes. The FOA listed institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations.
Were non-U.S. (foreign) organizations allowed to apply?
Yes. The FOA permitted non-domestic (non-U.S.) entities (foreign organizations).
Did the FOA allow international or cross-border collaboration?
Yes. In addition to foreign organizations, the FOA allowed regional organizations, U.S. territory or possession entities, and foreign components of U.S. organizations, indicating openness to international collaboration when scientifically justified.
Where can applicants find the full announcement details?
The full announcement was made available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-12-009.html.
Who should be contacted for technical issues accessing the announcement link?
For technical issues accessing or linking to the announcement, the contact provided was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What does it mean that the FOA was "discretionary"?
Based on the information provided, the FOA was described as a discretionary NIH grant opportunity, meaning it was a specific, time-limited funding call designed to support particular research goals rather than an always-open program.
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