Opportunity Information: Apply for RFA DA 16 013
Apply for RFA DA 16 013
- The HHS-NIH11 in the education, health sector is offering a public funding opportunity titled "Systems Biology Approaches in HIV/AIDS and Substance Use (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279,.
- This funding opportunity was created on Dec 10, 2015 and posted on Dec 10, 2015.
- Applicants must submit their applications by Apr 04, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The grant opportunity titled "Systems Biology Approaches in HIV/AIDS and Substance Use (R01)" (Funding Opportunity Number RFA-DA-16-013) is a discretionary NIH research grant program designed to fund systems biology projects that tackle high-priority questions about HIV/AIDS specifically in the context of drugs of abuse. The central idea is that substance use and substance use disorders can fundamentally change the biology of HIV infection and HIV-related outcomes, and those changes are often multifactorial and interconnected. Because of that complexity, the FOA emphasizes systems biology approaches, meaning research strategies that integrate multiple types of biological data and analytical methods to understand how interacting biological systems behave as a whole rather than studying a single pathway or factor in isolation.
The scientific focus is the biological intersection where HIV/AIDS and substance use overlap. The FOA highlights that substance use and abuse create distinct challenges across the full HIV continuum, including prevention, treatment, disease progression, and medical consequences. It also points to major translational endpoints where substance use may alter outcomes, such as the prospects for an HIV cure and the way people respond to vaccines or therapeutics. In practical terms, this implies interest in research that can explain how drugs of abuse and the physiological states associated with substance use influence host immunity, viral dynamics, inflammation, co-morbidities, treatment response, and other system-level processes that ultimately shape HIV acquisition risk and long-term health.
This opportunity uses the R01 mechanism, which is NIH's standard grant format for investigator-initiated research projects and generally supports substantial, hypothesis-driven or question-driven programs of work. The administering agency is within the U.S. Department of Health and Human Services, National Institutes of Health (listed as HHS-NIH11 in the source data). The activity category is listed under Education and Health, and the CFDA numbers associated with the program are 93.279 (reflecting the NIH portfolio area relevant to this announcement).
Eligibility is broad and includes many types of domestic organizations that commonly apply for NIH funding. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations both with and without 501(c)(3) status (as long as they are not institutions of higher education in the nonprofit category stated); for-profit organizations other than small businesses; and small businesses. The listing also includes an "Others" category with additional eligibility clarifications referenced in the full FOA text.
Key administrative details from the source record include a posted date and creation date of December 10, 2015, with an application closing date of April 4, 2016 (both the original and current closing date are the same). The source excerpt does not provide an award ceiling, expected number of awards, or other award size specifics, indicating those fields were left blank in the summarized data provided. Overall, the program is aimed at advancing an integrated, systems-level understanding of how substance use modifies HIV biology and clinical outcomes, with the broader goal of improving prevention and treatment strategies for populations affected by both HIV and drugs of abuse.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Systems Biology Approaches in HIV/AIDS and Substance Use (R01)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DA-16-013.
What type of grant mechanism does this opportunity use?
This opportunity uses the NIH R01 mechanism, which is NIH's standard research project grant format and is typically used for substantial, hypothesis-driven or question-driven research programs.
Which agency is administering the program?
The administering agency is the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), listed as HHS-NIH11 in the source data.
What is the overall purpose of this FOA?
The FOA is designed to fund systems biology research projects that address high-priority scientific questions about HIV/AIDS specifically in the context of drugs of abuse. The underlying premise is that substance use and substance use disorders can fundamentally change HIV biology and HIV-related outcomes in complex, interconnected ways.
What does "systems biology" mean in the context of this grant?
In this FOA, systems biology refers to research strategies that integrate multiple types of biological data and analytical methods to understand how interacting biological systems behave as a whole, rather than focusing on a single pathway or factor in isolation.
What scientific area does the FOA focus on?
The scientific focus is the biological intersection where HIV/AIDS and substance use overlap, especially how drugs of abuse and substance-use-associated physiological states influence host and viral processes that shape HIV acquisition risk and long-term health.
Why does this FOA emphasize the intersection of HIV and substance use?
The FOA emphasizes this intersection because substance use and substance use disorders can create multifactorial, interconnected changes that modify HIV infection and HIV-related outcomes. The complexity of these changes is a key reason the FOA prioritizes integrated, systems-level approaches.
Which parts of the HIV continuum are mentioned as being impacted by substance use?
The FOA highlights challenges across the full HIV continuum, including prevention, treatment, disease progression, and medical consequences.
What translational endpoints are highlighted in the FOA?
The FOA points to major translational endpoints where substance use may alter outcomes, including prospects for an HIV cure and how people respond to vaccines or therapeutics.
What kinds of biological processes or outcomes does the FOA suggest may be influenced by drugs of abuse?
Based on the description provided, the FOA implies interest in systems-level work examining how drugs of abuse and related physiological states may influence: host immunity, viral dynamics, inflammation, co-morbidities, treatment response, and other interconnected processes that affect HIV acquisition risk and long-term outcomes.
Is the program focused on a single pathway or factor in HIV biology?
No. The FOA explicitly emphasizes approaches that go beyond single-factor studies by using systems biology to understand interacting biological systems and multifactorial mechanisms.
Who is eligible to apply?
Eligibility is broad and includes many domestic organization types commonly eligible for NIH funding, including:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Other Native American tribal organizations
- Public housing authorities / Indian housing authorities
- Nonprofit organizations with 501(c)(3) status (other than institutions of higher education)
- Nonprofit organizations without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations other than small businesses
- Small businesses
The listing also includes an "Others" category with additional eligibility clarifications referenced in the full FOA text.
Are for-profit organizations eligible?
Yes. The eligibility list includes for-profit organizations other than small businesses and also explicitly includes small businesses.
Are tribal governments or tribal organizations eligible?
Yes. The eligibility list includes federally recognized Native American tribal governments and other Native American tribal organizations.
Are institutions of higher education eligible?
Yes. The eligibility list includes both public and state-controlled institutions of higher education and private institutions of higher education.
Are nonprofit organizations eligible?
Yes. The eligibility list includes nonprofit organizations with and without 501(c)(3) status, with the noted condition in the provided text that these categories are listed as other than institutions of higher education for the nonprofit category stated.
What is the CFDA number associated with this program?
The CFDA number associated with the program is 93.279.
What activity category is this opportunity listed under?
The activity category is listed under Education and Health.
When was the opportunity posted?
The posted date is December 10, 2015.
What is the creation date shown in the source record?
The creation date shown is December 10, 2015.
What is the application closing date?
The application closing date is April 4, 2016. The source record indicates the original and current closing dates are the same.
Does the provided summary include the award ceiling or expected number of awards?
No. The provided source excerpt does not include an award ceiling, expected number of awards, or other award size specifics; those fields are left blank in the summarized data provided.
What is the big-picture goal of funding this research?
The program aims to advance an integrated understanding of how substance use modifies HIV biology and clinical outcomes, with the broader goal of improving prevention and treatment strategies for populations affected by both HIV and drugs of abuse.
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| Drug Discovery For Nervous System Disorders (R21) Apply for PAR 16 042 Funding Number: PAR 16 042 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
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