Opportunity Information: Apply for PAR 15 020
Apply for PAR 15 020
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Systems Developmental Biology for Understanding Embryonic Development and the Ontogeny of Structural Birth Defects (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Oct 17, 2014 and posted on Oct 16, 2014.
- Applicants must submit their applications by Nov 10, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: County governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses City or township governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Private institutions of higher education Native American tribal governments (Federally recognized) State governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity titled "Systems Developmental Biology for Understanding Embryonic Development and the Ontogeny of Structural Birth Defects (R01)" (Funding Opportunity Number PAR 15-020) is an NIH discretionary research grant designed to push forward systems-level approaches to developmental biology. Its central goal is to support research that explains embryonic development as an integrated, multi-component process, focusing on how biological parts and processes interact to generate the complex outcomes seen in developing embryos. In this context, "systems developmental biology" means going beyond studying single genes, pathways, or cell types in isolation and instead investigating how networks of components work together over time and space to build tissues and organs, and how disruptions to those networks can lead to structural birth defects.
The scientific emphasis is on understanding embryonic development and the ontogeny (the origin and developmental progression) of structural birth defects. In practical terms, this encourages projects that connect multiple layers of biology such as gene regulation, signaling pathways, cell behaviors, tissue mechanics, and morphogenesis, with an eye toward explaining how coordinated interactions normally produce correct anatomical structures and how specific failures in coordination produce malformations. The R01 mechanism indicates the opportunity is intended for substantial, hypothesis-driven research projects that can sustain a robust, multi-year program of work, often involving interdisciplinary teams, integrated datasets, and analytical or computational strategies appropriate for complex developmental systems.
Administratively, this is a grant (Funding Instrument Type: Grant) in the broad activity area of health and related human services, with CFDA number 93.865 (Child Health and Human Development Extramural Research), reflecting alignment with NICHD-related priorities within NIH. The opportunity does not require cost sharing or matching, which generally means applicants are not expected to provide committed non-federal funds as a condition of the award. The FOA was posted on October 16, 2014, and the final listed closing date was November 10, 2016, with an archive date of December 11, 2016, meaning it was active for submissions during that period and is now archived as a historical announcement.
Eligibility is broad and includes many types of domestic and international organizations. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including 501(c)(3) and other nonprofit structures), for-profit organizations (including small businesses and other for-profits), and multiple levels of government such as state governments, county governments, city or township governments, special district governments, and independent school districts. It also includes public housing authorities/Indian housing authorities. The FOA explicitly extends eligibility to a wide range of institution types that NIH often highlights for inclusion and capacity building, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations where applicable.
Notably, the announcement allows non-U.S. entities to apply, including foreign organizations and foreign institutions, and it also permits non-domestic components of U.S. organizations. Foreign components, as defined by the NIH Grants Policy Statement, are allowed, which signals that NIH was open to strong, internationally based developmental biology research efforts or collaborations when scientifically justified. Regional organizations and U.S. territories or possessions are also listed as eligible. This wide eligibility range fits the interdisciplinary and global nature of modern developmental biology, where expertise, model systems, imaging platforms, and computational methods may be distributed across institutions and countries.
For applicants or institutions that needed help accessing the full announcement or experienced technical issues, the contact point listed is the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV). A link to the full FOA text was provided through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PAR-15-020.html, which would have contained the detailed scientific scope, application instructions, review criteria, and NIH policy requirements associated with the program during its active years.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Systems Developmental Biology for Understanding Embryonic Development and the Ontogeny of Structural Birth Defects (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR 15-020.
What agency is associated with this opportunity?
This is an NIH (National Institutes of Health) research grant opportunity. The information provided also references the NIH Office of Extramural Research (OER) as a contact point.
What type of funding instrument is this?
The funding instrument type is a Grant.
What mechanism does this opportunity use?
This opportunity uses the R01 mechanism, which is typically intended for substantial, hypothesis-driven research projects that can support a multi-year program of work.
What is the main purpose of this FOA?
The FOA is designed to advance systems-level approaches to developmental biology, with the central goal of supporting research that explains embryonic development as an integrated, multi-component process.
What does "systems developmental biology" mean in this context?
In this FOA, "systems developmental biology" means going beyond studying single genes, pathways, or cell types in isolation, and instead investigating how networks of biological components work together over time and space to build tissues and organs.
What scientific topics does the FOA emphasize?
The scientific emphasis is on understanding embryonic development and the ontogeny (origin and developmental progression) of structural birth defects, including how disruptions to coordinated developmental networks can lead to malformations.
What kinds of biological layers or processes are encouraged to be connected in proposed research?
The FOA encourages projects that connect multiple layers of biology such as gene regulation, signaling pathways, cell behaviors, tissue mechanics, and morphogenesis to explain how coordinated interactions produce correct anatomical structures and how failures in coordination produce structural birth defects.
Is the opportunity focused on single-factor studies (like one gene or one pathway)?
The description indicates a preference for systems-level work rather than studying single genes, pathways, or cell types in isolation, emphasizing integrated and network-based explanations of development.
What is the broader activity area for this grant?
The activity area is health and related human services.
What is the CFDA number listed for this opportunity?
The CFDA number is 93.865, labeled as Child Health and Human Development Extramural Research.
Does this grant require cost sharing or matching funds?
No. The opportunity states that it does not require cost sharing or matching, meaning applicants generally are not expected to provide committed non-federal funds as a condition of the award.
When was the FOA posted?
The FOA was posted on October 16, 2014.
What was the final closing date for submissions?
The final listed closing date was November 10, 2016.
Is this FOA still active?
No. The information provided indicates it is archived as a historical announcement, with an archive date of December 11, 2016.
Who is eligible to apply?
Eligibility is broad and includes many domestic and international organization types, including institutions of higher education (public, state-controlled, and private), nonprofit organizations (including 501(c)(3) and other nonprofit structures), for-profit organizations (including small businesses), and multiple levels of government.
Which levels of government are listed as eligible applicants?
The eligible government applicants listed include state governments, county governments, city or township governments, special district governments, independent school districts, and also public housing authorities/Indian housing authorities.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed as eligible.
Are regional organizations eligible to apply?
Yes. Regional organizations are listed as eligible applicants.
Are foreign (non-U.S.) organizations allowed to apply?
Yes. The announcement allows non-U.S. entities to apply, including foreign organizations and foreign institutions.
Are non-domestic components of U.S. organizations allowed?
Yes. The FOA permits non-domestic components of U.S. organizations.
Are foreign components allowed under NIH policy as referenced here?
Yes. The information notes that foreign components (as defined by the NIH Grants Policy Statement) are allowed, indicating NIH openness to international collaboration or internationally based efforts when scientifically justified.
Does the FOA specifically mention eligibility for certain institution types often highlighted for inclusion and capacity building?
Yes. The description explicitly mentions eligibility for HBCUs, Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations where applicable.
Where can applicants find the full FOA text?
The full FOA text is linked via the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PAR-15-020.html.
What kinds of details would the full FOA have contained during the active period?
The information indicates the full FOA would have contained detailed scientific scope, application instructions, review criteria, and NIH policy requirements associated with the program during its active years.
Who should be contacted for help accessing the full announcement or for technical issues?
The contact listed for help accessing the full announcement or for technical issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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