Opportunity Information: Apply for PAR 11 257
Apply for PAR 11 257
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Systems Developmental Biology for Understanding Embryonic Development and the Ontogeny of Structural Birth Defects (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.242 Mental Health Research Grants 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Oct 18, 2013 and posted on Jul 18, 2011.
- Applicants must submit their applications by Nov 1, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) County governments Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Independent school districts Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Public and State controlled institutions of higher education Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply.
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Opportunity Summary:
The grant opportunity "Systems Developmental Biology for Understanding Embryonic Development and the Ontogeny of Structural Birth Defects (R01)" (Funding Opportunity Number PAR-11-257) is an NIH discretionary research grant aimed at advancing systems-level approaches to developmental biology. The central goal is to support studies that explain embryonic development as an integrated, coordinated process, rather than as isolated gene or pathway effects. In this FOA, "systems developmental biology" means research that looks at how multiple biological components (for example, genes, regulatory elements, proteins, signaling pathways, cells, tissues, and biomechanical forces) interact over time to produce the complex events of embryogenesis, and how disruptions in those interacting networks can lead to structural birth defects. The emphasis is on understanding development as an emergent phenomenon that arises from many interacting parts working together across scales, from molecules to tissues to whole-organ structures.
Because the FOA explicitly links systems developmental biology to the "ontogeny of structural birth defects," it is oriented toward research that can clarify how normal developmental programs unfold and where, when, and why those programs go off track to produce congenital structural anomalies. In practical terms, this often points to integrative projects that combine experimental data with computational or quantitative frameworks capable of modeling dynamic developmental processes. Projects under this umbrella typically aim to map complex regulatory and cellular interactions, characterize developmental trajectories, and identify critical points of vulnerability where perturbations could produce lasting anatomical or organ-level changes.
This is an R01 mechanism, meaning it is designed for full-scale, hypothesis-driven research projects with a scope and duration consistent with standard NIH investigator-initiated research. The activity category is listed broadly under Health, Income Security, and Social Services, and it maps to multiple CFDA program areas, including oral diseases and disorders research (93.121), mental health research grants (93.242), biomedical research and research training (93.859), and child health and human development extramural research (93.865). That mix reflects how developmental biology and birth defects research can intersect with craniofacial development, neurodevelopment, general biomedical mechanisms, and child health outcomes, even when the primary focus is embryonic development and congenital structural conditions.
The opportunity does not require cost sharing or matching, which means applicants generally are not expected to contribute non-federal funds as a condition of the award. It was posted on July 18, 2011, with key dates indicating an original closing date of October 4, 2013, a current closing date of November 1, 2013, and an archive date of December 1, 2013. While those dates indicate this particular announcement is historical/archived, the content still illustrates NIH priorities at the time around integrating systems biology and developmental biology to better understand the origins of structural congenital anomalies.
Eligibility is intentionally broad and includes a wide range of domestic and international organizations. Eligible applicants include for-profit entities (including small businesses and other for-profit organizations), nonprofits (including those with and without 501(c)(3) status, excluding higher education institutions in that specific clause but including higher education elsewhere), public and state-controlled institutions of higher education, and private institutions of higher education. Government entities at multiple levels are eligible, including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also welcomes participation from tribal governments (federally recognized), tribal organizations (including those other than federally recognized tribal governments), and tribally controlled colleges and universities.
Additional categories explicitly called out as eligible include Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Importantly, non-U.S. (foreign) institutions are eligible to apply, and non-U.S. components of U.S. organizations are also eligible. That inclusion supports the idea that cutting-edge systems developmental biology can be international and collaborative, and that valuable model systems, datasets, or specialized expertise may reside outside the United States.
The sponsoring agency is the National Institutes of Health. Applicants were directed to the full FOA text at the NIH Grants Guide website (http://grants.nih.gov/grants/guide/pa-files/PAR-11-257.html). For technical difficulties accessing or linking to the announcement, the contact point provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, which signals that support for accessing the notice is centralized through NIH’s extramural infrastructure.
Overall, this FOA is best understood as NIH support for research that treats embryonic development as a complex system, encourages integrative and often quantitative approaches, and aims to connect systems-level developmental mechanisms to the real-world problem of how structural birth defects originate during development.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Systems Developmental Biology for Understanding Embryonic Development and the Ontogeny of Structural Birth Defects (R01)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PAR-11-257.
Which agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What type of grant mechanism is this?
This opportunity uses the R01 mechanism, which is intended for full-scale, hypothesis-driven research projects consistent with standard NIH investigator-initiated research in scope and duration.
What is the overall purpose of this FOA?
The central goal is to advance systems-level approaches to developmental biology by supporting studies that explain embryonic development as an integrated, coordinated process, rather than focusing only on isolated genes or single pathways.
What does "systems developmental biology" mean in this FOA?
In this announcement, "systems developmental biology" refers to research that examines how multiple biological components interact over time to produce embryogenesis. Components may include genes, regulatory elements, proteins, signaling pathways, cells, tissues, and biomechanical forces, with an emphasis on how these interactions across scales generate complex developmental outcomes.
How does this FOA relate to structural birth defects?
The FOA explicitly links systems developmental biology to the "ontogeny of structural birth defects," meaning it supports research aimed at understanding how normal developmental programs unfold and how, when, and why disruptions in interacting developmental networks can lead to congenital structural anomalies.
What kinds of scientific approaches are emphasized?
The emphasis is on integrative, systems-level approaches that may combine experimental data with computational or quantitative frameworks capable of modeling dynamic developmental processes over time.
What kinds of research goals or outputs are typical under this umbrella?
Projects commonly aim to map complex regulatory and cellular interactions, characterize developmental trajectories, and identify critical points of vulnerability where perturbations can produce lasting anatomical or organ-level changes.
Does this FOA focus on single-gene effects or isolated pathways?
No. The stated emphasis is on understanding embryonic development as an emergent phenomenon arising from many interacting parts working together across scales, rather than treating development as the sum of isolated gene or pathway effects.
What biological scales are included in the systems perspective?
The FOA highlights cross-scale integration, spanning from molecular components (such as genes and proteins) to higher levels of organization (such as cells, tissues, and whole-organ structures), including the role of biomechanical forces.
What activity category is associated with this opportunity?
The activity category is listed broadly under Health, Income Security, and Social Services.
Which CFDA program areas are referenced?
The opportunity maps to multiple CFDA program areas, including oral diseases and disorders research (93.121), mental health research grants (93.242), biomedical research and research training (93.859), and child health and human development extramural research (93.865).
Why does the FOA map to multiple CFDA areas?
The CFDA mix reflects how developmental biology and birth defects research can intersect with areas such as craniofacial development, neurodevelopment, general biomedical mechanisms, and child health outcomes, even when the core focus is embryonic development and congenital structural conditions.
Is cost sharing or matching required?
No. The FOA states that it does not require cost sharing or matching, so applicants generally are not expected to contribute non-federal funds as a condition of the award.
When was this opportunity posted?
It was posted on July 18, 2011.
What are the key dates (closing and archive dates) for this FOA?
The key dates listed include an original closing date of October 4, 2013, a current closing date of November 1, 2013, and an archive date of December 1, 2013.
Is this FOA current or archived?
Based on the listed closing and archive dates, this particular announcement is historical/archived.
Who is eligible to apply?
Eligibility is broad and includes domestic and international organizations across many sectors, including for-profit entities, nonprofits, higher education institutions, and multiple levels of government and tribal entities.
Are for-profit organizations eligible?
Yes. For-profit entities, including small businesses and other for-profit organizations, are listed as eligible applicants.
Are nonprofit organizations eligible?
Yes. Nonprofits (including those with and without 501(c)(3) status) are included among eligible applicants.
Are colleges and universities eligible?
Yes. Public and state-controlled institutions of higher education and private institutions of higher education are included.
Are state and local government entities eligible?
Yes. Eligible government applicants include state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are tribal entities eligible?
Yes. The FOA includes tribal governments (federally recognized), tribal organizations (including those other than federally recognized tribal governments), and tribally controlled colleges and universities.
Are minority-serving institutions explicitly included?
Yes. The FOA explicitly calls out eligibility for Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, and Historically Black Colleges and Universities (HBCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly listed among eligible applicants.
Are regional organizations eligible?
Yes. Regional organizations are explicitly included in the eligible applicant categories.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed among eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are included among the eligible applicant categories.
Are non-U.S. (foreign) institutions eligible?
Yes. Non-U.S. (foreign) institutions are eligible to apply.
Can non-U.S. components of U.S. organizations participate?
Yes. Non-U.S. components of U.S. organizations are also eligible.
Where can applicants find the full FOA text?
The full announcement text is available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PAR-11-257.html.
Who should be contacted for technical issues accessing or linking to the FOA?
For technical difficulties accessing or linking to the announcement, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the key theme of this FOA in plain terms?
The FOA supports research that treats embryonic development as a complex, coordinated system and encourages integrative (often quantitative) approaches to connect systems-level developmental mechanisms to how structural birth defects originate.
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