Opportunity Information: Apply for PAR 16 154
Apply for PAR 16 154
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Tailoring Dental Treatment for Individuals with Systemic Diseases that Compromise Oral Health (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121.
- This funding opportunity was created on Mar 25, 2016 and posted on Mar 25, 2016.
- Applicants must submit their applications by May 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The funding opportunity titled "Tailoring Dental Treatment for Individuals with Systemic Diseases that Compromise Oral Health (R01)" (Funding Opportunity Number PAR 16-154) is an NIH grant program designed to improve how dental care is delivered to people whose oral health is negatively affected by broader medical conditions. The core purpose is to close important knowledge gaps about which dental treatments work best for patients who have systemic diseases or other health conditions that make them more vulnerable to oral disease, complications, or poor healing. Rather than assuming standard dental approaches work equally well for everyone, this announcement is pushing for evidence that supports more personalized, condition-specific dental treatment guidance.
A central theme of the announcement is precision in dental treatment decision-making for medically complex populations. Applicants are encouraged to study how systemic illness changes oral disease presentation, progression, and response to therapy, and to identify measurable factors that help predict which patients will do well or poorly with specific dental interventions. This includes looking for predictors of outcomes within specific patient groups, such as clinical characteristics, disease severity, medication exposures, immune status, inflammatory markers, behavioral factors, or other relevant variables that could explain differences in treatment response. The goal is to generate stronger evidence that can be translated into clearer, more precise clinical guidelines tailored to the needs and risks of patients living with systemic conditions.
The announcement also signals an expectation that proposed studies will rely on established cohorts of individuals who already have the systemic disease or condition of interest. In practice, this means NIH is encouraging research designs that build on existing patient cohorts, registries, longitudinal studies, or other well-characterized populations where medical history, treatments, and outcomes may already be tracked. Using established cohorts can strengthen study feasibility, increase statistical power, and accelerate the production of results that are clinically meaningful, particularly when the patient populations are complex or when outcome events may be relatively uncommon.
This opportunity uses the R01 research project grant mechanism, which typically supports hypothesis-driven, investigator-initiated research and can accommodate a wide range of study types appropriate to the question being asked, including clinical studies, observational analyses, and other approaches that can produce actionable evidence about dental treatment outcomes in these populations. The funding instrument is a grant, the activity category is health, and the CFDA number associated with the program is 93.121. The sponsoring agency is the National Institutes of Health (listed as HHS-NIH11 in the source information).
Eligibility is broad and includes many types of organizations that commonly participate in NIH research. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions where applicable); for-profit organizations other than small businesses; small businesses; and other entities as described in the full eligibility guidance. This breadth suggests NIH intended the program to be accessible to academic institutions, health systems, research organizations, and other groups positioned to conduct rigorous clinical or population-based oral health research in medically affected cohorts.
The opportunity was posted on March 25, 2016, with an original and current closing date of May 7, 2019, indicating it was a time-limited announcement in that cycle. While the source fields do not specify an award ceiling or expected number of awards, the emphasis of the program is clear: produce practical, evidence-based insights that help dentists and healthcare teams choose and tailor oral disease treatments for patients whose systemic health conditions complicate oral care, ultimately improving outcomes and supporting more individualized clinical guidance.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The opportunity is titled "Tailoring Dental Treatment for Individuals with Systemic Diseases that Compromise Oral Health (R01)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PAR 16-154.
Which agency sponsors this grant opportunity?
The sponsoring agency is the National Institutes of Health (NIH), listed in the source information as HHS-NIH11.
What type of funding instrument is being offered?
The funding instrument is a grant.
What grant mechanism does this opportunity use?
This opportunity uses the NIH R01 research project grant mechanism.
What is the activity category for this opportunity?
The activity category is health.
What is the CFDA number associated with this program?
The CFDA number associated with the program is 93.121.
What is the main goal of this funding opportunity?
The main goal is to improve how dental care is delivered to people whose oral health is negatively affected by systemic diseases or other health conditions. The program aims to close key knowledge gaps about which dental treatments work best for patients who are medically complex or more vulnerable to oral disease, complications, or poor healing.
What kind of research emphasis does the announcement highlight?
A central emphasis is precision in dental treatment decision-making for medically complex populations. The announcement encourages evidence that supports more personalized, condition-specific dental treatment guidance rather than assuming standard dental approaches work equally well for all patients.
What types of questions are applicants encouraged to study?
Applicants are encouraged to study how systemic illness changes oral disease presentation, progression, and response to therapy, and to identify measurable factors that predict which patients will do well or poorly with specific dental interventions.
What kinds of predictors or measurable factors are mentioned as relevant?
The information provided lists examples such as clinical characteristics, disease severity, medication exposures, immune status, inflammatory markers, behavioral factors, and other relevant variables that could explain differences in treatment response within specific patient groups.
Is the opportunity focused on generating clinical guidance?
Yes. The stated goal is to generate stronger evidence that can be translated into clearer, more precise clinical guidelines tailored to the needs and risks of patients living with systemic conditions.
Does the announcement expect applicants to use established patient cohorts?
Yes. The announcement signals an expectation that proposed studies will rely on established cohorts of individuals who already have the systemic disease or condition of interest.
What does "established cohorts" mean in the context of this opportunity?
It refers to using existing patient cohorts, registries, longitudinal studies, or other well-characterized populations where medical history, treatments, and outcomes may already be tracked.
Why does NIH encourage the use of established cohorts for this research?
Using established cohorts can strengthen feasibility, increase statistical power, and speed up the production of results that are clinically meaningful, especially when patient populations are complex or when outcome events may be relatively uncommon.
What kinds of study designs are suggested as appropriate under this R01?
Based on the information provided, the R01 can support hypothesis-driven, investigator-initiated research and can accommodate a wide range of study types appropriate to the question being asked, including clinical studies and observational analyses aimed at producing actionable evidence about dental treatment outcomes in these populations.
Who is eligible to apply?
Eligibility is broad and includes many organization types, including: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions where applicable); for-profit organizations other than small businesses; small businesses; and other entities as described in the full eligibility guidance.
Does the eligibility list suggest what kinds of applicants NIH intended to reach?
Yes. The breadth of eligibility suggests NIH intended the program to be accessible to academic institutions, health systems, research organizations, and other groups positioned to conduct rigorous clinical or population-based oral health research in medically affected cohorts.
When was this opportunity posted?
The opportunity was posted on March 25, 2016.
What was the closing date for this opportunity?
The original and current closing date listed is May 7, 2019.
Is this described as a time-limited announcement?
Yes. The provided information indicates it was time-limited in that cycle, based on the posting and closing dates.
Does the provided information state an award ceiling or the expected number of awards?
No. The source fields described do not specify an award ceiling or the expected number of awards.
What is the practical impact this program is trying to achieve?
The practical impact is to produce evidence-based insights that help dentists and healthcare teams choose and tailor oral disease treatments for patients whose systemic health conditions complicate oral care, improving outcomes and supporting more individualized clinical guidance.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 16 154) also looked into and applied for these:
| Funding Opportunity |
|---|
| Tailoring Dental Treatment for Individuals with Systemic Diseases that Compromise Oral Health (R21) Apply for PAR 16 153 Funding Number: PAR 16 153 Agency: HHS-NIH11 Category: Health Funding Amount: $200,000 |
| NeuroNEXT Clinical Trials (U01) Apply for PAR 16 155 Funding Number: PAR 16 155 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Newborn Screening Implementation Program Regarding Conditions Added to the Recommended Uniform Screening Panel (RUSP) Apply for HRSA 16 062 Funding Number: HRSA 16 062 Agency: HHS-HRSA Category: Health Funding Amount: Case Dependent |
| Use of Imaging and Digital Image Analysis Software/s to Evaluate Transdermal Irritation and Non - inferiority of Generic Transdermal Products (U01) Apply for RFA FD 16 010 Funding Number: RFA FD 16 010 Agency: HHS-NIH11 Category: Health Funding Amount: $250,000 |
| Generic Drug Substitution in Special Populations (U01) Apply for RFA FD 16 011 Funding Number: RFA FD 16 011 Agency: HHS-NIH11 Category: Health Funding Amount: $200,000 |
| Adult Maturational Changes and Dysfunctions in Emotion Regulation (R01) Apply for RFA MH 17 405 Funding Number: RFA MH 17 405 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Preventing Teen Dating and Youth Violence by Addressing Shared Risk and Protective Factors Apply for CDC RFA CE16 1605 Funding Number: CDC RFA CE16 1605 Agency: HHS-CDC-NCIPC Category: Health Funding Amount: $412,500 |
| TRANSFORM/Primary Health Care Unit (PHCU) Apply for APS 663 16 000005 Funding Number: APS 663 16 000005 Agency: USAID-ETH Category: Health Funding Amount: $120,000,000 |
| NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00) Apply for PAR 16 156 Funding Number: PAR 16 156 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
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| Prevention Innovation Program III (PIP) (R01) Apply for RFA AI 16 025 Funding Number: RFA AI 16 025 Agency: HHS-NIH11 Category: Health Funding Amount: $400,000 |
| National Implementation and Dissemination for Chronic Disease Prevention Apply for CDC RFA DP14 141803CONT16 Funding Number: CDC RFA DP14 141803CONT16 Agency: HHS-CDC Category: Health Funding Amount: Case Dependent |
| Strategic Prevention Framework for Prescription Drugs (SPF Rx) Apply for SP 16 006 Funding Number: SP 16 006 Agency: HHS-SAMHS Category: Health Funding Amount: $371,616 |
| Grants to Prevent Prescription Drug/Opioid Overdose-Related Deaths (PDO) Apply for SP 16 005 Funding Number: SP 16 005 Agency: HHS-SAMHS Category: Health Funding Amount: $11,000,000 |
| Partnerships for Countermeasures against Select Pathogens (R01) Apply for RFA AI 16 034 Funding Number: RFA AI 16 034 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| HPV Roundtable: Creating a National Network of Partners to Promote Cancer Prevention through Human Papillomavirus Vaccination- Financed in Part by 2016 Prevention and Public Health Funds Apply for CDC RFA IP16 1602PPHF16 Funding Number: CDC RFA IP16 1602PPHF16 Agency: HHS-CDC-NCIRD Category: Health Funding Amount: $500,000 |
| New Technologies for the Glycosciences (R41/R42) Apply for PA 16 158 Funding Number: PA 16 158 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Cooperative Agreements for Tribal Behavioral Health Apply for SM 16 010 Funding Number: SM 16 010 Agency: HHS-SAMHS Category: Health Funding Amount: $200,000 |
| New Technologies for the Glycosciences (R43/R44) Apply for PA 16 157 Funding Number: PA 16 157 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Adult Maturational Changes and Dysfunctions in Emotion Regulation (R21) Apply for RFA MH 17 400 Funding Number: RFA MH 17 400 Agency: HHS-NIH11 Category: Health Funding Amount: $200,000 |
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