Targeted Radiochemistry and Associated Technology Development for Integrated Nuclear Medicine Research and Training with Human Application A Joint Research Funding Opportunity Announcement NIH, DOE | Apply Online

Opportunity Summary:

The funding opportunity DE-FOA-0001075, titled "Targeted Radiochemistry and Associated Technology Development for Integrated Nuclear Medicine Research and Training with Human Application," is a joint grant announcement from the U.S. Department of Energy (DOE) Office of Science, specifically the Office of Biological and Environmental Research (OBER), and the National Institutes of Health (NIH), through the National Institute of Biomedical Imaging and Bioengineering (NIBIB). It is a discretionary, science and technology research grant under the DOE Office of Science Financial Assistance Program (CFDA 81.049). The central theme is translational nuclear medicine, with a strong emphasis on developing radionuclide-based imaging biomarkers that can be used in human applications and on strengthening the training pipeline for the next generation of translational nuclear medicine researchers and clinicians.

The opportunity is designed around two tightly linked goals. First, it seeks the development of clinically relevant radionuclide imaging biomarkers that can help individualize and optimize patient care. In practice, this means supporting work that advances new or improved diagnostic imaging agents and theranostic approaches, where a related pair of agents (or a single platform) can be used for both imaging and therapy. The focus on biomarkers reflects an intent to move beyond basic radiotracer chemistry alone and into tools that can guide clinical decisions, such as selecting therapies, monitoring biological responses, stratifying patients, or predicting outcomes in a way that is practical for clinical workflows. Second, the program explicitly aims to enhance training opportunities for young scientists and clinicians in translational nuclear medicine, meaning the research environment is expected to double as a serious training platform rather than treating training as a minor add-on.

A defining feature of the solicitation is that applicants must already be positioned to conduct human-relevant translational work. The announcement stresses that applicants need access to existing advanced facilities and should assemble an interdisciplinary collaborative team. On the clinical side, this includes clinicians with expertise in nuclear medicine imaging techniques tailored to specific diseases or disorders. On the chemistry and biology side, it calls for radiochemists, synthetic chemists, and/or biochemists who can support radiotracer design, synthesis, and biological validation. The institutional setting is expected to promote broad collaborations between clinical physicians and basic or translational scientists, reflecting the reality that successful nuclear medicine translation requires coordinated work across chemistry, imaging physics, biology, regulatory quality expectations, and clinical implementation.

Because the program targets translational biomarker development with human application, the infrastructure requirements are emphasized as a form of readiness. Applicants should have easy access to advanced nuclear medicine imaging capabilities, explicitly including positron emission tomography (PET) and single photon emission computed tomography (SPECT). In addition, they should have radiochemistry laboratories able to handle radiotracer synthesis, validation, and quality control. This points to an expectation that proposed projects can realistically produce usable imaging agents and evaluate them with appropriate imaging platforms, supported by the practical capabilities needed for reproducible manufacturing and verification of tracer identity, purity, and performance. While the summary text does not list specific required regulatory milestones, the repeated emphasis on validation and quality control signals that the program is oriented toward work that can credibly bridge the gap between discovery and clinical utility.

Eligibility is broadly open: all entity types may apply with a few notable exclusions. Other federal agencies are not eligible to apply directly. Also excluded are Federally Funded Research and Development Center (FFRDC) contractors and certain nonprofit organizations described in section 501(c)(4) of the Internal Revenue Code that engaged in lobbying after December 31, 1995. At the same time, the FOA explicitly allows synergistic collaborations with researchers in federal laboratories and FFRDCs, including DOE National Laboratories, as long as those collaborations are used to fill critical gaps in expertise and do not dominate the project budget. A key constraint is that such collaborations can represent no more than 50 percent of the total budget, reinforcing the expectation that the lead applicant institution retains primary responsibility and capability for the core work.

From an administrative and funding perspective, the opportunity was posted February 6, 2014, with an original and final closing date of April 18, 2014, and it was archived July 18, 2014. The estimated total program funding was $5,000,000. The listing shows no explicit award ceiling or floor, which typically indicates that award sizes could vary based on merit, scope, and programmatic considerations rather than being bounded by a published per-award range. There is no cost sharing or matching requirement, reducing barriers for applicants by not requiring institutional financial contribution as a formal condition of the award.

For applicants or institutions, the FOA message is fairly clear about what a competitive proposal environment looks like: a credible, integrated clinical-to-chemistry pipeline; real access to PET/SPECT and radiochemistry capabilities; and a training plan that is naturally embedded in the research program. The joint NIH-DOE framing also implies an interest in projects that bring together DOE strengths in isotope science, radiochemistry, instrumentation, and large-facility capabilities with NIH priorities around human health impact, imaging biomarkers, and clinically relevant translation. Practical questions about the full announcement were directed to DOE contacts listed in the notice, including Kimberlie J. Laing (Grant Management Specialist) and Prem C. Srivastava (Program Manager).

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