Opportunity Information: Apply for RFA AI 14 021
Apply for RFA AI 14 021
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Targeting Latently Infected Cells Without Reactivation (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Mar 25, 2014 and posted on Mar 25, 2014.
- Applicants must submit their applications by Jul 15, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,700,000.00 to eligible and selected applicants.
- Eligible applicants include: State governments Public and State controlled institutions of higher education Special district governments Private institutions of higher education County governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities For profit organizations other than small businesses Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Targeting Latently Infected Cells Without Reactivation (R01) funding opportunity (RFA-AI-14-021) is an NIH discretionary research grant aimed at pushing HIV cure science beyond approaches that rely on waking the virus up. The central problem it addresses is the long-lived latent HIV-1 reservoir: even when a person is on fully suppressive highly active antiretroviral therapy (HAART), a small population of infected cells persists in a dormant state, allowing the virus to rebound if treatment stops. This FOA seeks projects that generate new knowledge and practical strategies to selectively eliminate those latently infected cells directly, without depending on viral reactivation as a prerequisite for killing them. In other words, it is looking for ways to find and remove the cells quietly carrying HIV rather than forcing them to produce virus first.
The scientific emphasis is on innovative research that clarifies mechanisms or develops approaches that could be harnessed to target latent infection. That can include technology-driven concepts and foundational mechanistic work that informs future therapies, with the explicit long-term goal of enabling curative interventions that eradicate the latent reservoir under conditions where standard therapy is already suppressing active viral replication. The announcement highlights the value of cross-disciplinary collaborations, signaling that proposals integrating multiple fields such as immunology, virology, cell biology, genomics, bioengineering, computational biology, drug discovery, or advanced diagnostics are particularly aligned with the intent. The underlying expectation is that breakthroughs in this space are likely to come from combining enabling technologies with strong biological insight, for example by improving how latently infected cells are identified, characterized, and selectively eliminated.
From an administrative standpoint, this is an R01 grant mechanism under the NIH, within health-related research activity categories tied to Allergy and Infectious Diseases Research (CFDA 93.855) and Microbiology and Infectious Diseases Research (CFDA 93.856). The opportunity does not require cost sharing or matching, which means applicants are not expected to contribute non-federal funds as a condition of the award. NIH estimated total funding for the opportunity was listed as $2,700,000 for the competition.
Eligibility is broad and spans many types of organizations. Domestic applicants can include state, county, city/township, and special district governments; public housing authorities; independent school districts; public and private institutions of higher education; and a wide range of nonprofit organizations, including both 501(c)(3) and non-501(c)(3) entities (with the noted caveat for those that are not institutions of higher education). For-profit organizations are eligible as well (other than small businesses, which are separately listed as eligible), and small businesses may apply. The FOA also explicitly includes a wide set of mission-focused and community-anchored institutions, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based and community-based organizations and eligible federal agencies. Importantly, the announcement allows non-U.S. participation: non-domestic (foreign) organizations and foreign institutions may apply, non-domestic components of U.S. organizations are eligible, and foreign components (as defined in NIH policy) are permitted. This reflects the global nature of HIV research and the need to draw on expertise and cohorts worldwide.
Key dates associated with this specific FOA include a posted and created date of March 25, 2014, an original and current closing date of July 15, 2014, and an archive date of August 15, 2014. While the opportunity itself is historical and archived, the description captures an enduring research priority area at NIH: developing cure-directed strategies that address HIV latency without relying on reactivation-based paradigms.
The administering agency is the National Institutes of Health. The full announcement was made available through the NIH grants guide at the link provided in the source material (http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-021.html). For technical issues accessing or linking to the announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is called "Targeting Latently Infected Cells Without Reactivation (R01)" and it is identified as RFA-AI-14-021.
Who is the administering agency?
The administering agency is the National Institutes of Health (NIH).
What type of grant mechanism is being used?
This opportunity uses the NIH R01 research grant mechanism.
What scientific problem is this FOA focused on?
It focuses on the long-lived latent HIV-1 reservoir: a small population of HIV-infected cells that persists in a dormant state even when a person is on fully suppressive highly active antiretroviral therapy (HAART). This reservoir enables viral rebound if treatment stops.
What is the main goal of the research supported by this FOA?
The goal is to generate new knowledge and practical strategies to selectively eliminate latently infected cells directly, without depending on viral reactivation as a prerequisite for killing them. In plain terms, it seeks ways to find and remove cells quietly carrying HIV rather than forcing them to produce virus first.
Does this FOA support "reactivation" or "wake up the virus" approaches?
The FOA is explicitly aimed at pushing HIV cure science beyond approaches that rely on waking the virus up. The intent is to target latently infected cells without requiring viral reactivation first.
What kinds of research projects are emphasized?
The emphasis is on innovative research that clarifies mechanisms or develops approaches that could be harnessed to target latent infection. This can include technology-driven concepts and foundational mechanistic work that informs future therapies, with a long-term aim of enabling curative interventions that eradicate the latent reservoir while standard therapy is already suppressing active viral replication.
What scientific disciplines are considered aligned with the intent of the FOA?
The FOA highlights the value of cross-disciplinary collaborations. It specifically notes areas such as immunology, virology, cell biology, genomics, bioengineering, computational biology, drug discovery, and advanced diagnostics as examples of fields that can be integrated in responsive proposals.
Why does the FOA emphasize cross-disciplinary collaboration?
The announcement signals an expectation that breakthroughs are likely to come from combining enabling technologies with strong biological insight, such as improving how latently infected cells are identified, characterized, and selectively eliminated.
What CFDA program areas are associated with this opportunity?
The FOA is tied to health-related research activity categories associated with Allergy and Infectious Diseases Research (CFDA 93.855) and Microbiology and Infectious Diseases Research (CFDA 93.856).
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching, meaning applicants are not expected to contribute non-federal funds as a condition of the award.
How much total funding was NIH estimated to make available for this competition?
NIH estimated total funding for the opportunity was listed as $2,700,000 for the competition.
What types of U.S. (domestic) organizations are eligible to apply?
Eligibility is broad and includes (among others): state governments; county governments; city or township governments; special district governments; public housing authorities; independent school districts; public and private institutions of higher education; and a wide range of nonprofit organizations including both 501(c)(3) and non-501(c)(3) entities (with the noted caveat for those that are not institutions of higher education).
Are for-profit organizations eligible?
Yes. For-profit organizations are eligible (other than small businesses, which are separately listed as eligible), and small businesses may apply.
Are community-anchored or mission-focused institutions eligible?
Yes. The FOA explicitly includes institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations.
Are eligible federal agencies allowed to apply?
Yes. Eligible federal agencies are included among eligible applicant types.
Is foreign (non-U.S.) participation allowed?
Yes. Non-domestic (foreign) organizations and foreign institutions may apply. In addition, non-domestic components of U.S. organizations are eligible, and foreign components (as defined in NIH policy) are permitted.
Why does the FOA allow non-U.S. participation?
The description ties this to the global nature of HIV research and the need to draw on expertise and cohorts worldwide.
When was this FOA posted and created?
The posted and created date is March 25, 2014.
What were the closing dates for this FOA?
The original and current closing date listed is July 15, 2014.
When was this FOA archived?
The archive date is August 15, 2014.
Is this funding opportunity still open?
No. Based on the dates provided, this specific FOA is historical and archived.
Where can the full announcement be found?
The full announcement is available through the NIH grants guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-021.html
Who is the contact for technical issues accessing or linking to the announcement?
For technical issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What is the broader research priority captured by this FOA, even though it is archived?
It captures an enduring NIH research priority: developing cure-directed strategies that address HIV latency without relying on reactivation-based paradigms.
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