Opportunity Information: Apply for RFA EB 09 002
Apply for RFA EB 09 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Technologies for Image Guided Interventions (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health.
- This funding opportunity was created on Oct 30, 2009 and posted on Oct 30, 2009.
- Applicants must submit their applications by Jan 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- Eligible applicants include: Small businesses City or township governments Private institutions of higher education Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education For profit organizations other than small businesses Independent school districts Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments State governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Technologies for Image Guided Interventions (R01) opportunity (Funding Opportunity Number RFA-EB-09-002) is a National Institutes of Health grant solicitation, issued through NIBIB under CFDA 93.286, aimed at pushing forward high-impact technologies for image guided interventions (IGI). In this context, IGI refers to procedures where medical imaging is used as a real-time or near-real-time navigation tool to guide a treatment or biopsy. The central idea is to help move healthcare away from more invasive, resource-heavy approaches and toward procedures that can be done with smaller incisions or no incisions at all, while still being accurate and clinically effective.
A major emphasis of the announcement is on disruptive innovation. The program is not simply looking for incremental upgrades to existing tools; it is looking for technologies that can realistically replace the current dominant approach for a clinical problem. The FOA frames disruption as technology that can make procedures faster, less invasive, and/or lower cost compared to standard care, with a clear line of sight to meaningful clinical impact. A typical example would be an image guided procedure that could take the place of an open or laparoscopic surgery, reducing recovery time and complications while preserving or improving outcomes.
This R01 is intended to fund what the announcement describes as the second phase of a two-phase effort. In practical terms, that means applicants are expected to be beyond early concept development. A key requirement is preliminary data showing a prototype system and demonstrating feasibility of the proposed image guided intervention. The grant is therefore positioned for teams that already have a working proof-of-concept and are ready to mature the technology toward something that is more complete, robust, and clinically relevant, with the potential to become a widely used intervention rather than a one-off research demo.
The FOA encourages multidisciplinary projects, which makes sense given that successful IGI work often requires tight integration across imaging science, software and hardware engineering, robotics or device development, clinical workflow design, and clinical domain expertise. Partnerships with industry are encouraged but not mandatory, reflecting the program interest in translation and eventual adoption without making industry collaboration a gatekeeping requirement. The announcement also signals interest in technology platforms, not just single-use solutions, meaning applicants can propose enabling systems that could be adapted across multiple diseases, procedures, or anatomical targets if the platform approach is well-justified and likely to broaden clinical value.
In terms of funding mechanics, the award uses the NIH Research Project Grant (R01) mechanism. NIBIB planned to commit up to $5,000,000 total in fiscal year 2010 to support approximately 4 to 6 awards, with an award ceiling listed as $750,000. There is no cost sharing or matching requirement stated for applicants. The opportunity was posted on October 30, 2009, with an original and current closing date of January 20, 2010, and it was archived on February 20, 2010.
Eligibility is broad and includes many types of organizations, spanning public and private institutions of higher education, nonprofit and for-profit organizations, small businesses, and multiple levels of government (state, county, city/township, special districts). It also includes a wide set of specialized eligible entities such as independent school districts, public housing authorities/Indian housing authorities, tribal organizations and governments (including federally recognized tribal governments), faith-based and community-based organizations, U.S. territories or possessions, and certain federally eligible agencies. The eligibility listing also explicitly includes a range of institution types such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities, as well as foreign (non-U.S.) entities and regional organizations.
Overall, the grant opportunity is best understood as NIH/NIBIB support for later-stage, prototype-backed development of image guided intervention technologies that can genuinely change clinical practice by replacing invasive or costly standard procedures with minimally invasive, image-guided alternatives. The projects most aligned with the FOA are those that combine strong preliminary feasibility evidence with a credible plan to deliver a clinically meaningful intervention or platform, ideally supported by a team that can bridge engineering innovation and real-world clinical implementation.
Frequently Asked Questions (FAQs)
What is the "Technologies for Image Guided Interventions (R01)" opportunity?
This is a National Institutes of Health (NIH) funding opportunity titled "Technologies for Image Guided Interventions (R01)," with Funding Opportunity Number RFA-EB-09-002. It is issued through the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under CFDA 93.286, and it focuses on advancing high-impact technologies for image guided interventions (IGI).
Which NIH institute is sponsoring this solicitation?
The solicitation is issued through the National Institute of Biomedical Imaging and Bioengineering (NIBIB), an NIH institute.
What does IGI (image guided interventions) mean in this program?
In this context, IGI refers to procedures where medical imaging is used as a real-time or near-real-time navigation tool to guide a treatment or biopsy.
What is the overarching goal of the FOA?
The goal is to push healthcare away from more invasive, resource-heavy approaches and toward procedures that can be done with smaller incisions or no incisions at all, while still being accurate and clinically effective.
What kinds of innovations is the program looking for?
The FOA emphasizes disruptive innovation. It is not focused on incremental upgrades to existing tools; it is looking for technologies that could realistically replace the current dominant approach for a clinical problem, with a clear path to meaningful clinical impact (for example, faster procedures, less invasiveness, and/or lower cost compared to standard care).
What does "disruptive" mean according to this announcement?
The FOA frames disruption as technology that can make procedures faster, less invasive, and/or lower cost than standard care, and that has a clear line of sight to meaningful clinical impact. A representative example described is an image guided procedure that could replace an open or laparoscopic surgery, reducing recovery time and complications while preserving or improving outcomes.
Is this grant aimed at early-stage concepts or more mature projects?
This R01 is positioned for teams beyond early concept development. It is described as the second phase of a two-phase effort, meaning applicants are expected to have moved past initial ideas and into prototype-backed feasibility.
Is preliminary data required?
Yes. A key requirement stated is preliminary data showing a prototype system and demonstrating feasibility of the proposed image guided intervention.
What level of development should applicants be at before applying?
Applicants should already have a working proof-of-concept (a prototype) with feasibility demonstrated, and should be ready to mature the technology toward something more complete, robust, and clinically relevant, with potential for wide use rather than a one-off research demonstration.
Does the FOA encourage multidisciplinary teams?
Yes. The FOA encourages multidisciplinary projects, reflecting the fact that successful IGI efforts often require integration across imaging science, software and hardware engineering, robotics or device development, clinical workflow design, and clinical domain expertise.
Are industry partnerships required?
No. Partnerships with industry are encouraged but not mandatory.
Does the program favor platforms or single-use solutions?
The FOA signals interest in technology platforms, not only single-use solutions. Applicants may propose enabling systems that could be adapted across multiple diseases, procedures, or anatomical targets if the platform approach is well-justified and likely to broaden clinical value.
What grant mechanism is used?
The award uses the NIH Research Project Grant (R01) mechanism.
How much funding was planned for this opportunity?
NIBIB planned to commit up to $5,000,000 total in fiscal year 2010 to support approximately 4 to 6 awards.
What is the award ceiling listed in the announcement?
The award ceiling is listed as $750,000.
Is cost sharing or matching required?
No cost sharing or matching requirement is stated for applicants.
When was this opportunity posted?
The opportunity was posted on October 30, 2009.
What was the closing date for applications?
The original and current closing date listed is January 20, 2010.
Is this funding opportunity still active?
No. The opportunity is archived, with an archived date of February 20, 2010.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofit and for-profit organizations (including small businesses), and multiple levels of government (including state, county, city/township, and special districts). It also includes specialized entities such as independent school districts, public housing authorities/Indian housing authorities, tribal organizations and governments (including federally recognized tribal governments), faith-based and community-based organizations, U.S. territories or possessions, and certain federally eligible agencies.
Are minority-serving institutions included in the eligibility list?
Yes. The eligibility listing explicitly includes institution types such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities.
Are foreign (non-U.S.) entities eligible?
Yes. The eligibility listing includes foreign (non-U.S.) entities, as well as regional organizations.
What types of projects are the best fit for this FOA?
Projects most aligned with the FOA combine strong preliminary feasibility evidence (including a prototype) with a credible plan to deliver a clinically meaningful image guided intervention or platform that could change practice by replacing invasive or costly standard procedures with minimally invasive, image-guided alternatives.
What kind of clinical impact is the FOA trying to achieve?
The FOA aims for technologies that can genuinely change clinical practice by replacing current dominant approaches for a clinical problem with interventions that reduce invasiveness, improve speed and efficiency, and/or reduce costs while maintaining or improving clinical outcomes.
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