Technology Based Interventions to Promote Engagement in Care and Treatment Adherence and For Substance Abusing Populations with HIV (R34) | Apply Online

Opportunity Summary:

The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), offered this grant opportunity to support early-stage research on technology-based tools that can help people living with HIV who also have substance use problems stay connected to HIV medical care and follow their treatment plans. The announcement is specifically for a Clinical Trial Planning Grant (R34), which is designed to help investigators build and refine an intervention and get the groundwork in place for a future, larger clinical trial. In practical terms, the FOA is about developing, pilot testing, and checking the real-world feasibility of technology tools, including mobile devices, that can improve engagement in HIV care and treatment adherence among substance-abusing populations with HIV.

The program emphasizes technology as a way to address common barriers that interfere with consistent HIV care in the context of substance use, such as missed appointments, unstable routines, transportation issues, stigma, competing priorities, and difficulties staying adherent to antiretroviral therapy. Applications were encouraged to test tools that could function in everyday life and real service settings, not just in ideal conditions. While the FOA highlights mobile devices, the intent is broader: it supports technology-enabled strategies that can improve how patients receive support and how clinics and service organizations deliver HIV care.

Research topics were framed around three main directions. First, projects could focus on patient-level interventions where technology directly supports outcomes like medication adherence, appointment keeping, retention in care, and other behaviors tied to viral suppression and overall health. Examples of the kinds of functions that fit this category include reminders, interactive self-management supports, symptom or side-effect tracking, two-way messaging, motivational or behavioral content, or other mobile or digital features aimed at helping participants stick with treatment and maintain regular care. Second, projects could concentrate on the readiness and capacity of HIV treatment providers or related organizations to adopt and integrate these technologies. That means studying implementation questions like staff workflow, training needs, acceptability, sustainability, privacy and confidentiality considerations, and the practical steps needed to embed a tool into routine care so it actually gets used. Third, projects could target the organization and delivery of HIV treatment and services, using technology to improve coordination, efficiency, and continuity across systems of care, such as strengthening communication between medical providers and support services or improving how care teams track and respond to patients who are falling out of care.

As an R34 planning and pilot mechanism, the grant was not mainly about running a fully powered efficacy trial. Instead, it supported the preparatory and feasibility work that makes a future clinical trial credible and well designed. That typically includes refining the intervention and its technical components, establishing recruitment and retention procedures for a population that can be hard to engage, testing data collection and outcome measures, confirming usability and acceptability, setting up clinical and research workflows, and generating pilot data to justify the next-stage study. The overall goal is to reduce the risk of failure in a later, larger trial by ensuring the intervention and study design are workable, relevant, and ready for more definitive testing.

Funding was offered as a discretionary grant under CFDA 93.279 (Drug Abuse and Addiction Research Programs). The posted date for the opportunity was March 23, 2012, with an original and current closing date listed as January 7, 2015, and an archive date of February 7, 2015. The award ceiling was $225,000, and there was no cost-sharing or matching requirement, which is typical for many NIH research grants.

Eligibility was broad and included many types of organizations capable of conducting health research, intervention development, and clinical trial planning. Eligible applicants included public and private institutions of higher education, nonprofits with or without 501(c)(3) status, small businesses, for-profit organizations (including those other than small businesses), independent school districts, city/county/state and special district governments, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. The FOA also explicitly included a wide range of additional eligible entities such as historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Non-U.S. entities (foreign institutions) were eligible to apply, and foreign components of U.S. organizations were allowed consistent with NIH policy.

The administering agency was NIH (with NIDA as the issuing institute). The full announcement was available through the NIH Grants Guide at the provided link (PA 12-118). For access or technical issues, the listed point of contact was the NIH Office of Extramural Research (OER) webmaster via the provided email addresses.

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