Opportunity Information: Apply for PAR 13 032
Apply for PAR 13 032
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Technology Development for High Throughput Structural Biology Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Mar 14, 2014 and posted on Nov 30, 2012.
- Applicants must submit their applications by Mar 14, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses Public housing authorities/Indian housing authorities Private institutions of higher education For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments City or township governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Technology Development for High Throughput Structural Biology Research (R01) is a National Institutes of Health funding opportunity from the National Institute of General Medical Sciences (NIGMS) that supports projects aimed at pushing the capabilities of high-throughput structural biology. The central goal is technology and methods development that makes it possible to produce proteins and determine their structures more efficiently, especially for targets that have traditionally been difficult or impractical to tackle at scale. Rather than focusing on routine structure determination of easy targets, the program is geared toward innovations that remove bottlenecks and expand what can be done in a high-throughput pipeline.
The opportunity is particularly interested in new ideas and practical approaches that improve protein production, sample preparation, and structure determination workflows. Projects can address high-throughput X-ray crystallography and high-throughput NMR, as well as other core tasks that contribute to structural biology and structural genomics. In practice, that can include enabling technologies across the full process, such as cloning and expression strategies, stabilization and purification methods, crystallization or sample optimization, data collection approaches, and computational or analytical methods that accelerate or automate key steps. The unifying theme is that the proposed work should meaningfully advance throughput, robustness, or feasibility for difficult classes of proteins.
A defining feature of this FOA is its emphasis on "challenging proteins" that are not currently amenable to high-throughput structural biology. The announcement explicitly highlights membrane proteins, small protein complexes, and proteins from humans and other higher eukaryotes, while leaving room for additional difficult target categories. These targets tend to present problems like low expression, instability, heterogeneity, conformational flexibility, or difficulties in crystallization and spectral quality, so competitive applications are expected to propose methods that directly address such barriers and make structural characterization more routine and scalable.
Mechanistically, the funding instrument is an NIH R01 research project grant, and it falls under the health funding activity category. There is no cost sharing or matching requirement listed. The associated CFDA number is 93.859 (Biomedical Research and Research Training). The funding opportunity number is PAR-13-032, and the opportunity is listed as discretionary.
Eligibility is broad and includes a wide range of applicant organizations. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, with the usual distinctions), for-profit organizations (including small businesses and other for-profits), and many government entities such as state governments, county governments, city or township governments, special district governments, and independent school districts. The eligibility language also extends to tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and other organizations as described in the FOA. Importantly, non-U.S. entities are eligible to apply, including foreign organizations and foreign institutions; non-U.S. components of U.S. organizations may apply; and foreign components are allowed under NIH policy definitions. The FOA also calls out eligibility for a variety of institution types, including HBCUs, Hispanic-serving institutions, AANAPISIs, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and faith-based or community-based organizations, among others.
Key administrative details in the source record include a posted date of November 30, 2012, with creation date March 14, 2014, and an archive date of April 14, 2014. The record shows an original closing date of January 7, 2016, alongside a current closing date of March 14, 2014, reflecting how the listing was captured and archived in the provided dataset. Applicants would normally rely on the official NIH program announcement page for authoritative due dates and submission details; the announcement link provided is http://grants.nih.gov/grants/guide/pa-files/PAR-13-032.html. For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, this FOA is best understood as a method-building and technology-advancement program for structural biology at scale, with a clear preference for proposals that can unlock high-throughput structure determination for hard targets that remain out of reach for standard pipelines.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled Technology Development for High Throughput Structural Biology Research (R01).
Which federal agency and NIH institute are offering this grant?
This is a National Institutes of Health (NIH) funding opportunity from the National Institute of General Medical Sciences (NIGMS).
What is the funding opportunity number?
The funding opportunity number is PAR-13-032.
What type of grant mechanism is used?
The award mechanism is an NIH R01 Research Project Grant.
What is the main purpose of this FOA?
The central purpose is technology and methods development that pushes the capabilities of high-throughput structural biology, making it possible to produce proteins and determine their structures more efficiently, especially for targets that are traditionally difficult or impractical to address at scale.
Is this FOA intended to fund routine structure determination projects?
No. The emphasis is on innovations that remove bottlenecks and expand what can be done in a high-throughput pipeline, rather than routine structure determination of easy targets.
What kinds of scientific approaches or workflows does the FOA encourage?
The FOA is interested in new ideas and practical approaches that improve protein production, sample preparation, and structure determination workflows, with a focus on advancing throughput, robustness, or feasibility for challenging protein targets.
Which structure determination platforms are specifically mentioned?
The announcement specifically mentions high-throughput X-ray crystallography and high-throughput NMR as areas that projects can address.
What parts of the high-throughput structural biology pipeline can be improved under this program?
The FOA describes enabling technologies across the full process, including (but not limited to):
- Cloning and expression strategies
- Stabilization and purification methods
- Crystallization or sample optimization
- Data collection approaches
- Computational or analytical methods that accelerate or automate key steps
What does the FOA mean by "challenging proteins"?
"Challenging proteins" are targets that are not currently amenable to high-throughput structural biology using standard approaches. These targets often present barriers that reduce success rates or slow down structural characterization.
Which protein target classes are explicitly highlighted as challenging?
The FOA explicitly highlights:
- Membrane proteins
- Small protein complexes
- Proteins from humans and other higher eukaryotes
It also leaves room for additional difficult target categories.
What types of bottlenecks or technical barriers does the FOA expect applicants to address?
The FOA notes that difficult targets can involve issues such as low expression, instability, heterogeneity, conformational flexibility, crystallization difficulties, or spectral quality problems. Competitive applications are expected to propose methods that directly address these types of barriers and make structural characterization more routine and scalable.
What is the funding activity category?
The listing places this opportunity under the health funding activity category.
Is cost sharing or matching required?
No cost sharing or matching requirement is listed for this opportunity.
What is the CFDA number associated with this opportunity?
The CFDA number is 93.859, described as Biomedical Research and Research Training.
Is this opportunity discretionary?
Yes. The opportunity is listed as discretionary.
Who is eligible to apply?
Eligibility is broad and includes a wide range of organizations, including:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations (including with and without 501(c)(3) status, as described)
- For-profit organizations (including small businesses and other for-profits)
- Government entities (including state, county, city or township governments, special district governments, and independent school districts)
- Tribal governments and tribal organizations
- Public housing authorities/Indian housing authorities
- Other organizations as described in the FOA
Are foreign (non-U.S.) organizations eligible?
Yes. The eligibility language states that non-U.S. entities are eligible to apply, including foreign organizations and foreign institutions. It also states that non-U.S. components of U.S. organizations may apply, and that foreign components are allowed under NIH policy definitions.
Does the FOA mention eligibility for minority-serving and other specific institution types?
Yes. The FOA calls out eligibility for a variety of institution types, including (among others):
- HBCUs (Historically Black Colleges and Universities)
- Hispanic-serving institutions
- AANAPISIs
- Tribally controlled colleges and universities
- Alaska Native and Native Hawaiian serving institutions
- Faith-based or community-based organizations
When was this opportunity posted and when was it archived?
The record lists a posted date of November 30, 2012, a creation date of March 14, 2014, and an archive date of April 14, 2014.
What are the due date details shown in the record?
The source record shows an original closing date of January 7, 2016 and a current closing date of March 14, 2014, which reflects how the listing was captured and archived in the provided dataset.
Where should applicants verify official due dates and submission instructions?
Applicants are expected to rely on the official NIH program announcement page for authoritative due dates and submission details. The link provided is:
http://grants.nih.gov/grants/guide/pa-files/PAR-13-032.html
What is the overall emphasis of this FOA in plain terms?
This FOA is best understood as a method-building and technology-advancement program for structural biology at scale, with a clear preference for proposals that unlock high-throughput structure determination for hard targets that remain out of reach for standard pipelines.
Who is listed as the contact for access or technical issues with the listing?
The contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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