Opportunity Information: Apply for PAR 13 033
Apply for PAR 13 033
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Technology Development for Protein Modeling (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Mar 14, 2014 and posted on Nov 30, 2012.
- Applicants must submit their applications by Mar 14, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments State governments Small businesses County governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) City or township governments For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Technology Development for Protein Modeling (R01) is an NIH grant opportunity from the National Institute of General Medical Sciences (NIGMS) that supports research aimed at pushing protein structure prediction forward, specifically by creating new technologies that make comparative (homology-based) protein modeling more accurate. The central goal is not simply to apply existing modeling tools to biological questions, but to develop methods, algorithms, or other enabling technologies that materially improve the quality and reliability of predicted protein structures when a related template structure is available. In practice, this is the kind of program that would fit teams working on better ways to select templates, improve sequence-to-structure alignments, handle difficult regions like loops and insertions, refine models toward physically realistic conformations, estimate model uncertainty, or otherwise address bottlenecks that limit comparative modeling accuracy.
The funding mechanism is an R01 research project grant, which is NIH s standard award type for investigator-initiated research. The opportunity is categorized as discretionary and falls under the health research activity area, with CFDA number 93.859 (Biomedical Research and Research Training). There is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of the award. While the posted date for the announcement was November 30, 2012, the record indicates it was ultimately archived in 2014 (Archive Date: April 14, 2014), with the current closing date shown as March 14, 2014 (and an original closing date of January 7, 2016 listed in the source data, suggesting the announcement dates changed over time). For practical purposes, that means this specific FOA is no longer active, but it still provides a clear picture of the kinds of technology-development proposals NIGMS wanted to encourage in this area.
Eligibility is broad and includes most common U.S. research and public-serving entities, as well as certain foreign organizations and components. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status, small businesses, for-profit organizations other than small businesses, and many levels of government (state, county, city or township, special district governments, independent school districts, and public housing authorities/Indian housing authorities). The eligibility section also explicitly covers a wide range of mission-focused institutions and community-based entities, including historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal government agencies. Importantly, non-U.S. entities are eligible to apply, including foreign organizations and foreign institutions; non-U.S. components of U.S. organizations may also participate, and foreign components are allowed consistent with the NIH Grants Policy Statement. This breadth signals that the NIH was open to strong technical ideas regardless of whether the work was centered in a university department, an institute, a nonprofit research organization, or an appropriately qualified commercial or international setting.
Administratively, the sponsoring agency is the National Institutes of Health, with NIGMS as the issuing institute. The full announcement was hosted on the NIH grants site (Additional Information Link: http://grants.nih.gov/grants/guide/pa-files/PAR-13-033.html). For access or technical issues with the online posting, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the "Technology Development for Protein Modeling (R01)" opportunity?
It is an NIH grant opportunity issued by the National Institute of General Medical Sciences (NIGMS) to support research that advances protein structure prediction by developing new technologies that improve comparative (homology-based) protein modeling when a related template structure is available.
Which NIH institute sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH), and the issuing institute is the National Institute of General Medical Sciences (NIGMS).
What does the program specifically want to fund?
The focus is on technology development that materially improves the accuracy and reliability of comparative protein models. The intent is to push the field forward by addressing bottlenecks that limit comparative modeling quality.
Is this opportunity meant for applying existing modeling tools to biological questions?
No. The central goal is not simply to apply existing protein modeling tools to biological problems, but to create methods, algorithms, or other enabling technologies that improve comparative modeling performance.
What kind of scientific work fits this program area?
Examples described include improving template selection, improving sequence-to-structure alignments, handling difficult regions such as loops and insertions, refining models toward physically realistic conformations, estimating model uncertainty, and tackling other limiting factors in comparative modeling accuracy.
What is the funding mechanism?
The mechanism is an R01 Research Project Grant, NIH's standard award type for investigator-initiated research.
What activity area does this opportunity fall under?
It is categorized under the health research activity area.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 93.859, titled "Biomedical Research and Research Training."
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal funds as a condition of the award.
Is this Funding Opportunity Announcement (FOA) currently active?
No. The record indicates the opportunity was archived (Archive Date: April 14, 2014), and the current closing date shown is March 14, 2014. Based on those dates, this specific FOA is no longer active.
Why do the dates look inconsistent (multiple closing dates)?
The source information notes a posted date of November 30, 2012, an archive date of April 14, 2014, a current closing date shown as March 14, 2014, and an original closing date of January 7, 2016 listed in the data. This suggests the announcement dates changed over time in the underlying record.
Who is eligible to apply?
Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status, small businesses, for-profit organizations other than small businesses, and multiple levels of U.S. government entities (including state, county, city or township, special district governments, independent school districts, and public housing authorities/Indian housing authorities).
Are minority-serving institutions specifically included as eligible applicants?
Yes. The eligibility description explicitly includes historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. The eligibility section explicitly includes faith-based or community-based organizations.
Can federal government agencies apply?
Yes. The eligibility description includes eligible federal government agencies.
Are non-U.S. (foreign) organizations allowed to apply?
Yes. The opportunity states that non-U.S. entities are eligible to apply, including foreign organizations and foreign institutions.
Can a U.S. organization include a non-U.S. component in the project?
Yes. Non-U.S. components of U.S. organizations may participate, and foreign components are allowed in a manner consistent with the NIH Grants Policy Statement.
Where can the full announcement be found?
The additional information link provided is: http://grants.nih.gov/grants/guide/pa-files/PAR-13-033.html
Who should be contacted for access or technical issues with the online posting?
The contact listed for access or technical issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the main takeaway if this FOA is archived?
Even though it is no longer active, the description still illustrates the type of technology-development work NIGMS sought to encourage for improving comparative protein modeling accuracy and reliability.
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