Opportunity Information: Apply for RFA DD 11 008
Apply for RFA DD 11 008
- The Centers for Disease Control and Prevention in the health sector is offering a public funding opportunity titled "The Association of Genetic Biomarkers and Hereditary Hemochromatosis (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.073 Birth Defects and Developmental Disabilities Prevention and Surveillance.
- This funding opportunity was created on Dec 10, 2010 and posted on Dec 10, 2010.
- Applicants must submit their applications by Feb 28, 2011 On time submission requires that electronic applications be error free and made available to CDC for processing from eRA Commons on or before the deadline date. Applications must be submitted to and validated successfully by Grants.gov/eRA Commons no later than 500 PM Eastern Time. Note HHS/CDC grant submission procedures do not provide a period of time beyond the application due date to correct any error or warning notices of noncompliance with application instructions that are identified by Grants.gov or eRA systems (i.e., error correction window).. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $300,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The government grant opportunity titled "The Association of Genetic Biomarkers and Hereditary Hemochromatosis (U01)" (Funding Opportunity Number RFA DD 11 008) was a Centers for Disease Control and Prevention (CDC) discretionary funding announcement focused on improving understanding of how genetic biomarkers relate to Hereditary Hemochromatosis. The core purpose was to support a project that would evaluate the relationship between genetic markers and the presence or expression of Hereditary Hemochromatosis by studying people with HFE mutations and comparing their genetic biomarkers alongside iron-related laboratory measures and relevant clinical information. In practical terms, the work was meant to connect genotype information (including HFE mutation status and other genetic markers) with biochemical indicators of iron overload and with clinical findings, to clarify how genetic variation maps to measurable iron outcomes and real-world health effects.
This opportunity used a cooperative agreement mechanism (U01), which generally indicates that the funded project would be carried out with substantial involvement from the CDC compared with a standard grant. The activity category was health, and the CFDA listing associated with it was 93.073 (Birth Defects and Developmental Disabilities, Prevention and Surveillance), reflecting a public health surveillance and prevention orientation rather than purely basic science. The announcement anticipated making a single award, meaning the CDC expected to fund one main project team or organization to carry out the proposed evaluation.
Funding levels were relatively modest and targeted: the estimated total funding available was $300,000, with an award ceiling of $150,000 and no stated award floor. There was no cost sharing or matching requirement, so applicants were not required to contribute non-federal funds as a condition of receiving the award. Eligibility was listed as unrestricted (open to any type of entity), subject to any additional clarifications that would have been included in the full announcement text. This kind of open eligibility typically allows a wide range of organizations to apply, such as universities, nonprofit research organizations, hospitals and health systems, governmental entities, or other qualified institutions capable of conducting genetic and clinical research with appropriate compliance structures.
The announcement timeline shows it was posted on December 10, 2010, with an original and current closing date of February 28, 2011, and an archive date of March 30, 2011. Applications had to be submitted electronically through Grants.gov and then validated through eRA Commons by 5:00 PM Eastern Time on the deadline date. The instructions emphasized that submissions needed to be error-free by the deadline and that CDC/HHS procedures did not provide an error-correction window after the due date, meaning applicants had to resolve system-identified errors before the cutoff to be considered on time.
Overall, the grant opportunity was designed to produce a clearer, evidence-based picture of how genetic biomarkers, particularly in individuals with HFE mutations, correlate with iron biochemistry and clinical presentation. By integrating genetic data with iron-related biochemical measures and clinical information, the funded project would be positioned to inform public health approaches to detection, surveillance, and potentially earlier or more targeted intervention for Hereditary Hemochromatosis. For applicants needing help accessing the full announcement at the time, the CDC Procurement and Grants Office, Technical Information and Management Section (TIMS), was listed as the point of contact by phone at 770-488-2700.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "The Association of Genetic Biomarkers and Hereditary Hemochromatosis (U01)."
What is the Funding Opportunity Number?
The Funding Opportunity Number is RFA DD 11 008.
Which federal agency offered this funding?
This was a Centers for Disease Control and Prevention (CDC) discretionary funding announcement.
What is the main purpose of the project supported by this grant?
The core purpose was to improve understanding of how genetic biomarkers relate to Hereditary Hemochromatosis by evaluating the relationship between genetic markers and the presence or expression of the condition.
What kinds of participants or samples were expected to be studied?
The project focus included studying people with HFE mutations and comparing their genetic biomarkers alongside iron-related laboratory measures and relevant clinical information.
What specific relationships was the project intended to evaluate?
The work was intended to connect genotype information (including HFE mutation status and other genetic markers) with biochemical indicators of iron overload and with clinical findings, to clarify how genetic variation maps to measurable iron outcomes and real-world health effects.
What is the funding mechanism, and what does it imply?
The opportunity used a cooperative agreement mechanism (U01). This generally indicates the funded project would be carried out with substantial involvement from the CDC compared with a standard grant.
What is the activity category for this opportunity?
The activity category was health.
What CFDA program listing was associated with this grant?
The CFDA listing associated with it was 93.073 (Birth Defects and Developmental Disabilities, Prevention and Surveillance).
What does the CFDA listing suggest about the orientation of the project?
It reflects a public health surveillance and prevention orientation rather than purely basic science.
How many awards did the CDC anticipate making?
The announcement anticipated making a single award, meaning the CDC expected to fund one main project team or organization to carry out the proposed evaluation.
How much total funding was estimated to be available?
The estimated total funding available was $300,000.
What was the maximum award amount (award ceiling)?
The award ceiling was $150,000.
Was there a minimum award amount (award floor)?
No award floor was stated.
Was cost sharing or matching required?
No. There was no cost sharing or matching requirement, so applicants were not required to contribute non-federal funds as a condition of receiving the award.
Who was eligible to apply?
Eligibility was listed as unrestricted (open to any type of entity), subject to any additional clarifications that would have been included in the full announcement text.
What kinds of organizations might fit under "unrestricted" eligibility?
This kind of open eligibility typically allows a wide range of organizations to apply, such as universities, nonprofit research organizations, hospitals and health systems, governmental entities, or other qualified institutions capable of conducting genetic and clinical research with appropriate compliance structures.
When was the opportunity posted?
The announcement was posted on December 10, 2010.
What was the application deadline?
The original and current closing date was February 28, 2011.
When was the opportunity archived?
The archive date was March 30, 2011.
How did applicants have to submit their applications?
Applications had to be submitted electronically through Grants.gov and then validated through eRA Commons.
What time were applications due on the deadline date?
Applications had to be submitted and validated by 5:00 PM Eastern Time on the deadline date.
What does "validated through eRA Commons" mean for submission timing?
The instructions emphasized that submissions needed to be error-free by the deadline and that applicants had to resolve system-identified errors before the cutoff to be considered on time.
Was there an error-correction window after the deadline?
No. The instructions stated that CDC/HHS procedures did not provide an error-correction window after the due date.
What was the overall public health value expected from the funded project?
By integrating genetic data with iron-related biochemical measures and clinical information, the project was positioned to inform public health approaches to detection, surveillance, and potentially earlier or more targeted intervention for Hereditary Hemochromatosis.
Who was the listed point of contact for help accessing the full announcement?
The CDC Procurement and Grants Office, Technical Information and Management Section (TIMS), was listed as the point of contact.
What phone number was provided for the point of contact?
The phone number provided was 770-488-2700.
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