Opportunity Information: Apply for RFA PS 14 001
Apply for RFA PS 14 001
- The Centers for Disease Control and Prevention in the health sector is offering a public funding opportunity titled "The Cooperative Re Engagement Controlled Trial (CoRECT)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.943 Epidemiologic Research Studies of Acquired Immunodeficiency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) Infec.
- This funding opportunity was created on Jan 8, 2014 and posted on Nov 18, 2013.
- Applicants must submit their applications by Jan 16, 2014 Letter of Intent Due Date December 16, 2013. Application Due Date January 16, 2014 by 500 PM U.S. Eastern Time. Special Date A conference call with the eligible applicants will be held Thursday, December 5, 2013 at 200pm ET. The bridge number is 1 866 620 0420, passcode 8943360.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $6,900,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $2,300,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- The following organizations are eligible to apply Competition is limited to state, local, and territorial health departments that are independently funded by CDC to perform HIV surveillance or their Bona Fide Agents. Funding decisions may also consider geographic diversity (e.g., applications that increase the diversity of geographic regions defined by the Department of Health and Human Services (http://www.hhs.gov/about/regionmap.html) represented in the program in order to maximize the program s flexibility in addressing evolving public health research needs related to HIV that may vary by geographic region. Competition is further limited to health departments who meet the three special eligibility criteria listed in Section III.3 below. 3. Special Eligibility Requirements a. Applicants must have complete HIV laboratory reporting of CD4 and viral load test results, defined as follows3 i. The jurisdiction s laws/regulations require the reporting of all CD4 and viral load results to the state/city health department ii. A minimum of 95 of HIV related test results from laboratories that perform HIV related testing for each area are being reported to the state/city health department iii. The jurisdiction is reporting at least 95 of all CD4 and viral load test results to CDC as of this application s deadline date. b. Applicants may not be a grantee of The Care and Prevention in the United States (CAPUS) Demonstration Project (FOA # CDC RFA PS12 1210), information available at http://www.cdc.gov/hiv/prevention/demonstration/capus/index.html c. Applicants must have more than 10,000 adults and adolescents living with diagnosed HIV infection, year end 2010, in their jurisdiction based on estimates in CDC s HIV Surveillance. Report available at http://www.cdc.gov/hiv/library/reports/surveillance/index.html As of July 19, 2013, the eligible states are Massachusetts, Michigan, New York (excluding New York City), South Carolina, and Washington. The eligible local health departments are the District of Columbia, Los Angeles County, New York City, Philadelphia, and San Francisco (Table 1). State and local health departments are responsible for and have authority to conduct HIV surveillance and to provide linkage to HIV medical care for all HIV infected individuals within their jurisdiction. Eligibility for this FOA is limited to state and local health departments because a critical component of this study includes the use of state and local health department surveillance data and the provision of field services by health department trained personnel with the relevant field services training to locate, contact, and provide assistance (i.e., appointment date and transport) to link people to HIV medical care.
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Opportunity Summary:
The Cooperative Re Engagement Controlled Trial (CoRECT) is a CDC funded cooperative agreement designed to test a practical, real world strategy for finding people with diagnosed HIV who have fallen out of HIV medical care and actively helping them return to care. The opportunity is grounded in a central public health problem in the United States: antiretroviral therapy (ART) can reliably suppress HIV viral load and protect both individual health and community health, but many people never achieve durable viral suppression because they are not successfully linked to care after diagnosis or they drop out of ongoing care. CoRECT focuses on that gap by evaluating whether closer, structured collaboration between health departments and HIV clinics, paired with proactive public health field services, can measurably improve re engagement, retention, and viral suppression outcomes.
At the core of the project is a controlled trial that uses existing data streams to identify individuals who are "recently out of care." Participating jurisdictions share health department HIV laboratory surveillance data (especially CD4 and viral load results) alongside clinic appointment information. These data are reviewed together in monthly case conferences that bring health departments and clinics into the same workflow for identifying specific people who appear to have disengaged from care. Once identified, eligible individuals are randomized to one of two approaches: an active intervention led by health department field services staff, or the usual linkage and engagement services available in the jurisdiction. This design is meant to move beyond demonstration projects and provide stronger evidence about whether the added field services component truly changes outcomes.
The active intervention is intentionally hands on. Health department staff use field services to locate and contact the person, assess barriers, and provide practical assistance to re connect them to HIV medical care. A key feature described in the announcement is facilitating rapid access, including arranging a same day appointment when possible, and offering support that can include appointment coordination and transportation assistance. The comparison arm receives standard linkage and engagement in care services, allowing the study to estimate the added value of proactive field based outreach over routine practice.
CoRECT evaluates multiple outcomes that reflect the HIV care continuum. The main goals are to determine whether the active field services approach increases re engagement in HIV medical care, improves retention in care after re entry, and increases the proportion of participants who achieve HIV viral load suppression compared with usual services. Taken together, these outcomes address not only whether people come back for a visit, but whether they stay connected long enough to benefit clinically and reduce transmission risk at the population level. The broader purpose is to demonstrate both feasibility (whether health department clinic collaboration and data exchange can be operationalized reliably) and effectiveness (whether the intervention produces better clinical and public health results).
This opportunity was issued as a discretionary funding announcement under Funding Opportunity Number RFA PS 14 001, using the cooperative agreement mechanism, which generally implies substantial involvement by CDC in oversight and implementation support compared with a typical grant. The funding activity category is health, and the CFDA listing is 93.943 (Epidemiologic Research Studies of AIDS and HIV Infection). The estimated total funding was $6.9 million, with an expected three awards. Individual awards were anticipated in the $2.0 million to $2.3 million range (floor $2,000,000; ceiling $2,300,000). There was no cost sharing or matching requirement.
Eligibility was narrowly limited because the intervention depends on public health surveillance authority and field services capacity. Competition was restricted to state, local, and territorial health departments that are independently funded by CDC to conduct HIV surveillance (or their bona fide agents). In addition, applicants had to meet special eligibility requirements tied to the completeness and quality of HIV laboratory reporting: jurisdictional requirements for reporting all CD4 and viral load results, evidence that at least 95 percent of HIV related test results were being reported to the health department, and that at least 95 percent of CD4 and viral load results were being reported onward to CDC by the application deadline. Applicants also could not be grantees of the CAPUS Demonstration Project (CDC RFA PS12 1210), and they needed to serve a jurisdiction with more than 10,000 adults and adolescents living with diagnosed HIV infection as of year end 2010, based on CDC surveillance estimates. The announcement listed eligible jurisdictions at the time, including certain states (Massachusetts, Michigan, New York excluding New York City, South Carolina, and Washington) and select local health departments (District of Columbia, Los Angeles County, New York City, Philadelphia, and San Francisco). Funding decisions could also consider geographic diversity across HHS regions to ensure a spread of settings and improve the program's ability to address evolving needs.
Key dates show that this was a time limited, archived opportunity. The posting date was November 18, 2013, with a letter of intent due December 16, 2013, and applications due January 16, 2014 by 5:00 PM Eastern Time. A pre application conference call for eligible applicants was scheduled for December 5, 2013. The archive date was February 15, 2014. The sponsoring agency was the Centers for Disease Control and Prevention, and assistance for accessing the full announcement was routed through the CDC Procurement and Grants Office Technical Information Management Section (TIMS).
In practical terms, CoRECT was an attempt to rigorously test a model many jurisdictions already suspected was important: when health departments and clinics routinely share information and coordinate outreach, they can more quickly identify people who have fallen out of care and intervene before lapses become prolonged. By pairing surveillance based identification with randomized assignment and measurable clinical endpoints, the program sought to produce actionable evidence on whether investing in structured data sharing and public health field services can reliably move people back onto ART and toward viral suppression.
Frequently Asked Questions (FAQs): CoRECT (Cooperative Re Engagement Controlled Trial)
What is the CoRECT funding opportunity?
CoRECT (the Cooperative Re Engagement Controlled Trial) is a CDC-funded cooperative agreement created to test a practical, real-world strategy for finding people with diagnosed HIV who have fallen out of HIV medical care and actively helping them return to care.
What public health problem is CoRECT trying to address?
CoRECT is focused on a key gap in the HIV care continuum: although antiretroviral therapy (ART) can reliably suppress HIV viral load and protect both individual and community health, many people do not achieve durable viral suppression because they are not successfully linked to care after diagnosis or they drop out of ongoing care.
What is the main goal of CoRECT?
The main goals are to determine whether an active, field-services-led approach increases (1) re-engagement in HIV medical care, (2) retention in care after re-entry, and (3) viral load suppression compared with usual linkage and engagement services.
What type of award mechanism is used for CoRECT?
CoRECT was issued as a cooperative agreement, which generally means CDC has substantial involvement in oversight and implementation support compared with a typical grant.
Which agency is sponsoring this opportunity?
The sponsoring agency is the Centers for Disease Control and Prevention (CDC).
What is the Funding Opportunity Number (FON) for CoRECT?
The Funding Opportunity Number listed for this announcement is RFA PS 14 001.
What is the CFDA number and program area associated with this opportunity?
The CFDA listing is 93.943, titled "Epidemiologic Research Studies of AIDS and HIV Infection." The funding activity category is health.
How does CoRECT identify people who are "recently out of care"?
The trial uses existing data streams, including health department HIV laboratory surveillance data (especially CD4 and viral load results) and clinic appointment information. These data are reviewed jointly by health departments and clinics to identify individuals who appear to have disengaged from care.
How do health departments and clinics work together during the project?
Participating jurisdictions share surveillance lab data and clinic appointment information and review them together in monthly case conferences. These case conferences are used to identify specific individuals who are likely out of care and to coordinate the next steps.
How often are the joint reviews conducted?
The announcement describes monthly case conferences where health departments and clinics review relevant data together.
What is the study design used in CoRECT?
CoRECT is a controlled trial. Once eligible individuals are identified as recently out of care, they are randomized to one of two approaches: an active intervention led by health department field services staff, or the usual linkage and engagement services available in the jurisdiction.
What is the active intervention in CoRECT?
The active intervention is a hands-on approach led by health department field services staff. Staff locate and contact the person, assess barriers to care, and provide practical assistance to reconnect them to HIV medical care.
What kinds of help can be provided under the active intervention?
The announcement highlights facilitating rapid access to care, including arranging a same-day appointment when possible. Support may include appointment coordination and transportation assistance.
What does the comparison group receive?
Individuals randomized to the comparison arm receive the standard linkage and engagement in care services available in the jurisdiction (the "usual services").
Why does CoRECT include a comparison arm with usual services?
Including a usual-services arm allows the study to estimate the added value of proactive, field-based outreach beyond routine practice and to produce stronger evidence than a demonstration-only project.
What outcomes does CoRECT evaluate?
CoRECT evaluates outcomes aligned with the HIV care continuum: re-engagement in HIV medical care, retention in care after re-entry, and viral load suppression.
What is meant by "feasibility" in this project?
Feasibility refers to whether structured collaboration between health departments and HIV clinics, along with data exchange and coordinated workflows (like monthly case conferences), can be operationalized reliably.
What is meant by "effectiveness" in this project?
Effectiveness refers to whether the active field services intervention produces better clinical and public health outcomes than usual services, particularly improved re-engagement, retention, and viral suppression.
Who was eligible to apply?
Eligibility was restricted to state, local, and territorial health departments that are independently funded by CDC to conduct HIV surveillance (or their bona fide agents), because the intervention depends on public health surveillance authority and field services capacity.
What special eligibility requirements were tied to laboratory reporting?
Applicants had to be in jurisdictions requiring reporting of all CD4 and viral load results, show evidence that at least 95 percent of HIV-related test results were being reported to the health department, and that at least 95 percent of CD4 and viral load results were being reported onward to CDC by the application deadline.
Were there restrictions related to other CDC projects?
Yes. Applicants could not be grantees of the CAPUS Demonstration Project (CDC RFA PS12 1210).
Was there a minimum jurisdiction size requirement?
Yes. Applicants needed to serve a jurisdiction with more than 10,000 adults and adolescents living with diagnosed HIV infection as of year-end 2010, based on CDC surveillance estimates.
Which jurisdictions were listed as eligible in the announcement?
The announcement listed eligible jurisdictions at the time including certain states (Massachusetts, Michigan, New York excluding New York City, South Carolina, and Washington) and select local health departments (District of Columbia, Los Angeles County, New York City, Philadelphia, and San Francisco).
How much funding was available under CoRECT?
The estimated total funding was $6.9 million, with an expected three awards.
What was the anticipated award size per recipient?
Individual awards were anticipated in the $2.0 million to $2.3 million range, with a funding floor of $2,000,000 and a ceiling of $2,300,000.
Was cost sharing or matching required?
No. The announcement stated there was no cost sharing or matching requirement.
Did CDC consider geographic diversity in making awards?
Yes. Funding decisions could consider geographic diversity across HHS regions to ensure a spread of settings and improve the program's ability to address evolving needs.
When was the opportunity posted?
The posting date was November 18, 2013.
Was a letter of intent required, and when was it due?
A letter of intent was due December 16, 2013.
When were applications due?
Applications were due January 16, 2014 by 5:00 PM Eastern Time.
Was there a pre-application conference call?
Yes. A pre-application conference call for eligible applicants was scheduled for December 5, 2013.
Is this opportunity still active?
No. The announcement was time-limited and archived. The archive date was February 15, 2014.
Where was assistance provided for accessing the full announcement?
Assistance for accessing the full announcement was routed through the CDC Procurement and Grants Office Technical Information Management Section (TIMS).
What makes CoRECT different from a typical demonstration project?
CoRECT was designed to generate stronger evidence by using a controlled trial with random assignment and measurable clinical endpoints, rather than only demonstrating that a model can be implemented.
What is the core strategy CoRECT is testing?
The project tests whether structured collaboration between health departments and HIV clinics, paired with proactive public health field services, can more quickly identify people who have fallen out of care and improve re-engagement, retention, and viral suppression.
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