Opportunity Information: Apply for PA 11 027
Apply for PA 11 027
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "The Development Of Frontal Cortex And Limbic System And Their Roles In Drug Abuse (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Dec 11, 2013 and posted on Nov 10, 2010.
- Applicants must submit their applications by Dec 11, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Special district governments Private institutions of higher education State governments For profit organizations other than small businesses Independent school districts County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Development Of Frontal Cortex And Limbic System And Their Roles In Drug Abuse (R01) is a National Institute on Drug Abuse (NIDA) Funding Opportunity Announcement (FOA) under the National Institutes of Health (NIH) that supports investigator-initiated Research Project Grant (R01) applications focused on basic neuroscience. The central theme is brain development: how the frontal and prefrontal cortices develop, how they interact with key subcortical limbic-system regions, and how these developing circuits shape emotional regulation, motivation, learning, memory, and other behaviors that are tightly linked to substance use, addiction, and related psychiatric conditions. The FOA also emphasizes a second, closely related priority: understanding how exposure to drugs of abuse can disrupt the normal cellular and molecular programs that build and refine these circuits, potentially altering reward processing and vulnerability to addiction across development.
In terms of scientific scope, the announcement targets the developmental biology and neurobiology of interconnected brain systems rather than narrow, single-region questions. It encourages studies of the frontal and prefrontal cortices alongside midbrain and basal forebrain structures and other limbic-related circuitry that contribute to reward, reinforcement, and motivated behavior. These systems are also described as relevant to the euphoric properties of drugs, the mechanisms of psychotherapeutic agents, and higher-order functions such as cognition, emotion, and memory. Projects responsive to the FOA would typically investigate fundamental mechanisms like neuronal differentiation and maturation, synapse formation and pruning, circuit wiring and plasticity, and the molecular signals and cellular interactions that guide these steps. A major interest is how these processes unfold over time and how developmental timing might influence later behavioral outcomes related to drug reward and addiction.
A key goal is to link normal developmental mechanisms to drug-abuse relevance in a biologically grounded way. The FOA specifically calls for research into how drugs of abuse affect the cellular and molecular mechanisms underlying nervous system development, particularly in circuits implicated in drug reward and addiction. This can include examining how exposure during sensitive periods (for example, prenatal development, adolescence, or other windows of rapid cortical and limbic maturation) alters circuit assembly, neurotransmitter system development, gene expression programs, synaptic plasticity, or long-term functional connectivity. The intent is to generate foundational knowledge that can clarify why certain developmental stages confer higher risk, how early neurobiological changes might persist, and which mechanisms could be targeted for prevention or treatment.
Administratively, this opportunity is identified as Funding Opportunity Number PA 11 027 and uses the NIH R01 grant mechanism, meaning it supports discrete, hypothesis-driven research projects that can vary in approach but are expected to be rigorous, well-justified, and impactful. The activity category is listed under Education and Health, and the CFDA number is 93.279 (Drug Abuse and Addiction Research Programs). Cost sharing or matching is not required, which is typical for many NIH research grants.
Eligibility is broad and includes a wide range of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education, nonprofits with or without 501(c)(3) status (including those outside higher education), for-profit organizations (including small businesses and other for-profits), state and local governments (such as state governments, county governments, city or township governments, special district governments, and independent school districts), public housing authorities/Indian housing authorities, and tribal entities including federally recognized tribal governments and other tribal organizations. The FOA also explicitly notes additional eligible groups such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, foreign organizations (non-U.S. entities), and eligible federal agencies.
Timeline information in the source indicates the FOA was posted on November 10, 2010, with an original closing date of January 7, 2014, and an archive date of January 11, 2014. The record also lists a current closing date of December 11, 2013 and a creation date of December 11, 2013, reflecting how the opportunity was tracked in the system prior to being archived. Because it is archived, it is not an active solicitation now, but it remains a useful reference point for the kind of basic developmental neuroscience questions NIDA has prioritized in relation to addiction.
For official details, the FOA points to the NIH grants page at http://grants.nih.gov/grants/guide/pa-files/PA-11-027.html. For access or technical issues related to the online announcement, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The opportunity is titled "The Development Of Frontal Cortex And Limbic System And Their Roles In Drug Abuse (R01)."
Which agency is offering this opportunity?
This is a National Institute on Drug Abuse (NIDA) Funding Opportunity Announcement (FOA) under the National Institutes of Health (NIH).
What is the funding mechanism for this FOA?
The FOA uses the NIH Research Project Grant (R01) mechanism, supporting investigator-initiated, discrete, hypothesis-driven research projects.
What is the FOA number?
The Funding Opportunity Number is PA 11 027.
What is the CFDA number associated with this program?
The CFDA number listed is 93.279 (Drug Abuse and Addiction Research Programs).
What general research area does this FOA support?
The FOA supports investigator-initiated Research Project Grant (R01) applications focused on basic neuroscience, with a central theme of brain development as it relates to substance use, addiction, and related psychiatric conditions.
What is the central scientific theme of the announcement?
The central theme is brain development: how the frontal and prefrontal cortices develop, how they interact with key subcortical limbic-system regions, and how developing circuits shape emotional regulation, motivation, learning, memory, and other behaviors tightly linked to substance use and addiction.
What related priority does the FOA emphasize in addition to normal development?
A closely related priority is understanding how exposure to drugs of abuse can disrupt the normal cellular and molecular programs that build and refine frontal cortex and limbic-system circuits, potentially affecting reward processing and vulnerability to addiction across development.
Does the FOA focus on single brain regions or interconnected systems?
The announcement targets the developmental biology and neurobiology of interconnected brain systems rather than narrow, single-region questions. It encourages studies that consider frontal and prefrontal cortices together with midbrain, basal forebrain, and other limbic-related circuitry.
Which brain regions and circuits are highlighted as relevant?
Highlighted systems include the frontal and prefrontal cortices and their interactions with subcortical limbic-system regions, including midbrain and basal forebrain structures and other circuitry involved in reward, reinforcement, and motivated behavior.
What kinds of behaviors or functions are these brain systems linked to in the FOA?
The FOA connects these developing circuits to emotional regulation, motivation, learning, memory, cognition, and other higher-order functions, all of which are described as tightly linked to substance use, addiction, and related psychiatric conditions.
How does the FOA connect this science to drug abuse and addiction?
The FOA aims to link normal developmental mechanisms to drug-abuse relevance in a biologically grounded way, including how development influences later behavioral outcomes related to drug reward and addiction and how drugs of abuse may alter circuit development and vulnerability.
What types of fundamental developmental mechanisms are considered responsive?
Examples named in the announcement include neuronal differentiation and maturation, synapse formation and pruning, circuit wiring and plasticity, and the molecular signals and cellular interactions that guide these steps.
Does the FOA emphasize developmental timing?
Yes. A major interest is how developmental processes unfold over time and how developmental timing may influence later behavioral outcomes related to drug reward and addiction.
What does the FOA say about sensitive developmental periods?
It notes that exposure during sensitive periods (for example, prenatal development, adolescence, or other windows of rapid cortical and limbic maturation) may alter circuit assembly and related mechanisms, potentially affecting risk and vulnerability across development.
What kinds of drug-exposure impacts are within scope?
The FOA describes research into how drugs of abuse affect cellular and molecular mechanisms underlying nervous system development, including potential impacts on circuit assembly, neurotransmitter system development, gene expression programs, synaptic plasticity, and long-term functional connectivity.
Is the FOA interested in long-term or persistent effects of early exposure?
Yes. The intent includes generating foundational knowledge about why certain developmental stages confer higher risk, how early neurobiological changes might persist, and which mechanisms could be targeted for prevention or treatment.
Are psychotherapeutic agents mentioned in the scientific context?
Yes. The systems of interest are described as relevant to the euphoric properties of drugs, the mechanisms of psychotherapeutic agents, and higher-order brain functions such as cognition, emotion, and memory.
What is the activity category listed for this opportunity?
The activity category is listed under Education and Health.
Is cost sharing or matching required?
No. Cost sharing or matching is not required.
Who is eligible to apply?
Eligibility is broad and includes domestic and non-domestic organizations, including public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), and various government entities.
Which government entities are included as eligible applicants?
Eligible government applicants include state governments, county governments, city or township governments, special district governments, independent school districts, public housing authorities/Indian housing authorities, and eligible federal agencies.
Are tribal entities eligible to apply?
Yes. The FOA includes tribal entities, including federally recognized tribal governments and other tribal organizations.
Are foreign (non-U.S.) organizations eligible?
Yes. The FOA explicitly includes foreign organizations (non-U.S. entities) as eligible applicants.
Are HBCUs and other minority-serving institutions specifically included?
Yes. The FOA explicitly notes eligibility for Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly includes faith-based or community-based organizations among eligible applicants.
Are U.S. territories or possessions included?
Yes. The FOA mentions U.S. territories or possessions as eligible.
When was this FOA posted?
The source indicates the FOA was posted on November 10, 2010.
What were the closing and archive dates listed for this opportunity?
The original closing date is listed as January 7, 2014, and the archive date is January 11, 2014. The record also lists a current closing date of December 11, 2013 and a creation date of December 11, 2013 as part of how it was tracked prior to being archived.
Is this funding opportunity currently active?
No. The opportunity is archived, so it is not an active solicitation now.
Why might an archived FOA still be useful?
Even though it is archived, it can still serve as a reference for the types of basic developmental neuroscience questions NIDA has prioritized in relation to addiction.
Where can I find the official FOA details?
The FOA points to the NIH grants page at http://grants.nih.gov/grants/guide/pa-files/PA-11-027.html.
Who is the contact for access or technical issues with the online announcement?
The contact listed for access or technical issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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