The Effects of Alcohol on Glial Cells (R01) | Apply Online

Opportunity Summary:

The Effects of Alcohol on Glial Cells (R01) is a National Institutes of Health funding opportunity issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to support research projects that directly examine how alcohol affects glial cells in the brain and how those glial changes, in turn, influence neurons and behavior. The core scientific focus is on identifying alcohol driven alterations in glial biology, including shifts in glial gene expression, activation of neuroimmune and proinflammatory signaling pathways, and impacts on glial survival. A major emphasis is connecting these glial level effects to downstream consequences such as changes in glia-neuron communication, neuronal gene expression programs, neuronal activity patterns, neuronal survival, and measurable behavioral outcomes related to alcohol exposure.

This announcement uses the NIH R01 mechanism, meaning it is intended for full scale, hypothesis driven research projects with a substantial scope compared to smaller exploratory mechanisms. The FOA is paired with a parallel announcement of the same scientific scope that uses the R21 exploratory/developmental mechanism (RFA-AA-09-004), which is typically more appropriate for early stage, higher risk pilot work. In practice, applicants proposing mature, well supported aims with robust preliminary data would generally align with the R01 track, while projects that are still establishing feasibility or opening a new direction could be better matched to the R21 companion.

NIAAA planned an estimated total of 2,000,000 USD in funding under this opportunity and anticipated making roughly 3 to 5 awards, indicating a relatively targeted competition aimed at a small number of well aligned projects. The program falls under the Health funding activity category and is associated with CFDA 93.273 (Alcohol Research Programs). There is no cost sharing or matching requirement, so applicants are not required to contribute non federal funds as a condition of the award.

Eligibility is broad and includes many organization types across the public, private, nonprofit, and governmental landscape. Eligible applicants include public and state controlled institutions of higher education and private institutions of higher education; nonprofit organizations both with and without 501(c)(3) status (with the non-501(c)(3) category excluding institutions of higher education); for profit organizations other than small businesses, as well as small businesses; and multiple levels of government including state governments, county governments, city or township governments, special district governments, and independent school districts. It also includes public housing authorities/Indian housing authorities and several categories of tribal entities, including federally recognized Native American tribal governments and other tribal organizations. The eligibility language also extends to various mission focused and geographically defined institutions and entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith based or community based organizations, regional organizations, and U.S. territories or possessions. Notably, the announcement indicates that non domestic (non U.S.) entities (foreign organizations) are also eligible, along with eligible federal agencies, reflecting NIH’s openness to scientifically qualified applicants beyond the typical domestic academic setting.

Key dates listed for the opportunity show it was posted and created on December 5, 2008, with an original and current closing date of March 26, 2009, and an archive date of April 26, 2009. The funding opportunity number is RFA-AA-09-003. Additional details and the full official text were provided through the NIH grants site link associated with the announcement. For access or technical issues related to the electronic posting, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

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Previous opportunity: OVC FY 09 2010 NCVRW Resource Guide

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