Opportunity Information: Apply for RFA HG 14 027
Apply for RFA HG 14 027
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "The Electronic Medical Records and Genomics (eMERGE) Network, Phase III Central Sequencing and Genotyping Facility (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Jul 17, 2014 and posted on Jul 17, 2014.
- Applicants must submit their applications by Nov 12, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $4,000,000.00 in funding.
- Eligible applicants include: Independent school districts Public and State controlled institutions of higher education County governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses For profit organizations other than small businesses State governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The funding opportunity RFA HG 14 027, titled "The Electronic Medical Records and Genomics (eMERGE) Network, Phase III Central Sequencing and Genotyping Facility (U01)," is a National Institutes of Health (NIH) cooperative agreement designed to support the eMERGE Network during its Phase III work. The main aim is to keep moving genomic discovery and real-world implementation research forward by funding one or more centralized facilities that can provide sequencing and genotyping services for the broader eMERGE consortium. In practical terms, the award is meant to underwrite the large-scale generation of genomic data that can be linked with electronic medical record (EMR) information so that researchers across the network can study how genetic variation relates to health outcomes and how genomic findings can be responsibly and effectively integrated into clinical care.
This FOA uses the U01 mechanism, which signals a cooperative agreement rather than a standard research grant. That typically means NIH expects to have substantial programmatic involvement, such as coordinating scientific priorities, ensuring harmonized methods, and helping manage how the central facility interacts with multiple network sites. The focus on a "central sequencing and genotyping facility(ies)" highlights a network-wide infrastructure approach: instead of each participating site independently generating genomic data, the program emphasizes standardized laboratory processes, consistent quality control, and efficient production pipelines that can serve multiple research and implementation projects under the eMERGE umbrella. Centralization is especially important for a network like eMERGE because cross-site consistency in sequencing or genotyping platforms, sample handling, variant calling, and data formatting can directly affect whether results can be pooled, compared, and replicated across large and diverse patient populations.
From an administrative standpoint, the opportunity falls under the Health activity category and is associated with CFDA number 93.172 (Human Genome Research), aligning it with NHGRI-style infrastructure and research support for genomics. The total estimated funding amount listed is $4,000,000, and the award ceiling is also $4,000,000, indicating the FOA anticipated up to that amount in total support (and that individual awards would not exceed that ceiling). The posting date and creation date are both July 17, 2014, with an original and current closing date of November 12, 2014, and an archive date of December 13, 2014. No cost sharing or matching requirement is indicated, meaning applicants were not expected to provide mandatory matching funds as a condition of receiving an award.
Eligibility is broad and spans many types of domestic organizations that commonly participate in NIH-funded research infrastructure, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3) categories), small businesses, for-profit entities (including those other than small businesses), and a range of government entities such as state, county, city/township, special district governments, and public housing authorities/Indian housing authorities. The FOA also explicitly mentions eligibility for various mission-driven and capacity-building institution types, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies. Tribal governments and tribal organizations are included in multiple forms, with distinctions between federally recognized tribal governments and other tribal entities.
At the same time, the opportunity draws a clear boundary around foreign involvement. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible. In addition, foreign components, as defined in the NIH Grants Policy Statement, are not allowed. This reflects a program design centered on U.S.-based clinical and research infrastructure, likely because of the sensitive nature of linking genomic information with EMR-derived clinical data, the regulatory environment around human subjects and health data, and the operational need to align participants under consistent U.S. governance, privacy, and oversight structures.
Overall, this FOA is best understood as an infrastructure-enabling research award meant to power the network's genomic data generation at scale. By supporting a centralized sequencing and genotyping facility, NIH aimed to strengthen the backbone of eMERGE Phase III so that multiple sites could rely on a shared, standardized genomics pipeline. That, in turn, supports the network's broader goals: discovering genetic associations using clinically rich EMR-linked cohorts and testing approaches for implementing genomic information in real healthcare settings. For those seeking the full official announcement, the FOA points to the NIH grants guide link (http://grants.nih.gov/grants/guide/rfa files/RFA HG 14 027.html), and it provides the NIH Office of Extramural Research (OER) webmaster contact for access or linking issues (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs): RFA HG 14 027 - The Electronic Medical Records and Genomics (eMERGE) Network, Phase III Central Sequencing and Genotyping Facility (U01)
What is the name and number of this funding opportunity?
The funding opportunity is RFA HG 14 027, titled "The Electronic Medical Records and Genomics (eMERGE) Network, Phase III Central Sequencing and Genotyping Facility (U01)."
Which agency is offering this opportunity?
This opportunity is offered through the National Institutes of Health (NIH).
What is the purpose of this FOA?
The purpose is to support the eMERGE Network during Phase III by funding one or more centralized facilities that provide sequencing and genotyping services for the broader eMERGE consortium. The intent is to enable large-scale genomic data generation that can be linked with electronic medical record (EMR) information to advance genomic discovery and implementation research.
What does the award support in practical terms?
It supports large-scale generation of genomic data (through sequencing and genotyping) in a way that allows linkage to EMR-derived clinical information, so researchers across the eMERGE Network can study relationships between genetic variation and health outcomes and evaluate responsible, effective clinical integration of genomic findings.
What grant mechanism is used, and what does it imply?
The FOA uses the U01 mechanism, which is a cooperative agreement. This implies NIH expects substantial programmatic involvement, such as coordinating scientific priorities, ensuring harmonized methods, and helping manage how the central facility interacts with multiple network sites.
Why does the FOA emphasize a central sequencing and genotyping facility?
Centralization supports a network-wide infrastructure approach, emphasizing standardized laboratory processes, consistent quality control, and efficient production pipelines that can serve multiple eMERGE projects rather than having each site generate data independently.
How does centralization help the eMERGE Network scientifically?
For a multi-site network like eMERGE, cross-site consistency in sequencing/genotyping platforms, sample handling, variant calling, and data formatting affects whether results can be pooled, compared, and replicated across large and diverse patient populations.
What is the activity category and CFDA number associated with this opportunity?
The opportunity is in the Health activity category and is associated with CFDA number 93.172 (Human Genome Research).
What is the estimated total funding amount and the award ceiling?
The total estimated funding amount is $4,000,000, and the award ceiling is also $4,000,000. Individual awards were not expected to exceed that ceiling.
When was the opportunity posted, and what were the key dates?
The posting date and creation date are both July 17, 2014. The original and current closing date is November 12, 2014. The archive date is December 13, 2014.
Is cost sharing or matching required?
No. The opportunity indicates no cost sharing or matching requirement, meaning applicants were not expected to provide mandatory matching funds as a condition of receiving an award.
Who is eligible to apply (in general terms)?
Eligibility is broad and includes many types of domestic U.S. organizations, including higher education institutions, nonprofits, small businesses, for-profit entities, and a range of government entities.
Are public and private universities eligible?
Yes. The FOA includes public and state-controlled institutions of higher education and private institutions of higher education.
Are nonprofit organizations eligible?
Yes. Nonprofits are eligible, including 501(c)(3) and non-501(c)(3) nonprofit organizations.
Are small businesses and for-profit organizations eligible?
Yes. Small businesses are listed as eligible, and for-profit organizations (including those other than small businesses) are also listed as eligible.
Are government entities eligible applicants?
Yes. Eligibility includes government entities such as state governments, county governments, city/township governments, special district governments, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. Tribal governments and tribal organizations are included, including distinctions between federally recognized tribal governments and other tribal entities.
Are federally recognized and non-federally recognized tribal entities addressed?
Yes. The eligibility language includes multiple forms of tribal participation and distinguishes between federally recognized tribal governments and other tribal entities.
Are mission-driven and capacity-building institution types specifically mentioned?
Yes. The FOA explicitly mentions eligibility for institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly mentions faith-based or community-based organizations as eligible.
Are federal agencies eligible to apply?
Yes. The FOA indicates eligible federal agencies are included among eligible applicants.
Are foreign organizations eligible to apply?
No. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are not eligible to apply.
Can a U.S. organization include a non-domestic component?
No. Non-domestic components of U.S. organizations are also not eligible under this FOA.
Are foreign components allowed under NIH policy definitions?
No. The FOA states that foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
What is the overall program emphasis of this FOA?
The FOA is best understood as an infrastructure-enabling research award intended to power genomic data generation at scale for eMERGE Phase III through shared, standardized sequencing and genotyping services.
How does this FOA relate to EMRs and clinical implementation?
It supports generating genomic data that can be linked to EMR information, enabling research on genetic associations using clinically rich cohorts and testing approaches for integrating genomic information into real healthcare settings.
Where is the official FOA announcement posted?
The FOA points to the NIH grants guide link: http://grants.nih.gov/grants/guide/rfa_files/RFA-HG-14-027.html
Who can be contacted for access or linking issues related to the FOA page?
The FOA lists the NIH Office of Extramural Research (OER) webmaster contact: FBOWebmaster@OD.NIH.GOV
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Previous opportunity: The Electronic Medical Records and Genomics (eMERGE) Network, Phase III Coordinating Center (U01)
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