Opportunity Information: Apply for RFA HD 15 032

  • The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "The Human Placenta Project Developing Paradigm Shifting Innovations for in vivo Human Placental Assessment (U34)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Feb 26, 2015 and posted on Jan 29, 2015.
  • Applicants must submit their applications by Feb 26, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $300,000.00 in funding.
  • Eligible applicants include: Small businesses Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education State governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts City or township governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Public and State controlled institutions of higher education County governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The Human Placenta Project: Developing Paradigm Shifting Innovations for in vivo Human Placental Assessment (U34) is a National Institutes of Health (NIH) funding opportunity designed to jump-start the earliest stages of creating brand-new, or clearly next-generation, ways to evaluate the human placenta during pregnancy while it is still in the body. The central goal is to expand what clinicians and researchers can safely measure about placental structure and function in vivo across the full course of gestation, with an emphasis on innovative imaging and assessment technologies or methods that could change the field rather than incremental improvements to existing tools.

This announcement uses the U34 cooperative agreement mechanism, which generally means NIH expects substantial involvement from program staff as the project develops, with a focus on guiding, coordinating, and shaping the early development pathway. The work supported here is positioned as an initial development phase rather than a large-scale, late-stage clinical validation effort. In practical terms, the opportunity targets teams that are still establishing feasibility, defining performance characteristics, building prototypes, refining analytic approaches, or otherwise laying the technical and methodological groundwork required before a technology can be tested broadly in pregnancy research or clinical settings.

The opportunity is listed under Funding Opportunity Number RFA-HD-15-032 and falls within the Health category (CFDA 93.865, Child Health and Human Development Extramural Research). Total estimated funding is about $2.5 million, with an award ceiling of $300,000 per award. There is no cost sharing or matching requirement, which lowers the barrier for applicants who might not have access to significant institutional cost-share resources. The original posting date was January 29, 2015, and the announcement was created February 26, 2015. The key dates shown include an original closing date of March 31, 2015, a current closing date of February 26, 2015, and an archive date of March 26, 2015, indicating this was a time-limited solicitation.

Eligibility is broad and spans many organization types, reflecting the interdisciplinary nature of placenta technology development. Eligible applicants include small businesses, for-profit organizations (including those other than small businesses), nonprofits (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education in those specific nonprofit categories), private and public institutions of higher education, and a wide range of government entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. Tribal eligibility is also explicitly included, covering federally recognized tribal governments as well as other Indian/Native American tribal governments, and tribally controlled colleges and universities.

The eligibility section also calls out additional categories, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. Notably, the announcement also allows non-domestic (non-U.S.) entities (foreign organizations), which signals NIH interest in drawing on specialized global expertise in imaging, biomarker development, computational methods, or device engineering that could accelerate progress in placental assessment.

Overall, the program is aimed at advancing safe, in vivo assessment of the placenta throughout pregnancy by enabling paradigm-shifting tools and approaches. The emphasis on "entirely new or next generation" methods underscores that the intent is to expand what can be measured or observed in real time during gestation, potentially opening doors to better understanding placental development and dysfunction and, over the longer term, improving pregnancy monitoring and outcomes.

For full details, NIH provided the official announcement link at http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-15-032.html. For access or technical issues with the online posting, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

Frequently Asked Questions (FAQs)

What is the Human Placenta Project: Developing Paradigm Shifting Innovations for in vivo Human Placental Assessment (U34)?

This NIH funding opportunity supports the earliest stages of developing brand-new, or clearly next-generation, ways to assess the human placenta during pregnancy while it is still in the body (in vivo). The intent is to expand what clinicians and researchers can safely measure about placental structure and function across the full course of gestation.

What is the main goal of this funding opportunity?

The central goal is to enable paradigm-shifting tools, technologies, or methods that allow safer and more informative in vivo measurement of placental structure and function throughout pregnancy, rather than incremental improvements to existing approaches.

What kinds of approaches does NIH emphasize for this program?

The program emphasizes innovative imaging and assessment technologies or methods that could change the field. The focus is on approaches that significantly expand what can be observed or measured in real time during gestation.

What does "in vivo human placental assessment" mean in this context?

It refers to evaluating the placenta during pregnancy while it remains in the body, with an emphasis on safe measurement across the entire course of gestation.

What is the funding mechanism used for this opportunity?

This announcement uses the U34 cooperative agreement mechanism.

What does a U34 cooperative agreement imply about NIH involvement?

A cooperative agreement generally means NIH expects substantial involvement from program staff as the project develops, including helping guide, coordinate, and shape the early development pathway.

Is this opportunity intended for late-stage clinical validation studies?

No. The supported work is positioned as an initial development phase, not a large-scale, late-stage clinical validation effort.

What stage of technology development is this opportunity targeting?

It targets teams establishing feasibility, defining performance characteristics, building prototypes, refining analytic approaches, or otherwise laying the technical and methodological groundwork needed before broad testing in pregnancy research or clinical settings.

What is the Funding Opportunity Number for this announcement?

The Funding Opportunity Number is RFA-HD-15-032.

Which agency is offering this grant?

The opportunity is offered by the National Institutes of Health (NIH).

What is the program/category listing for this opportunity?

It is listed in the Health category and includes CFDA 93.865 (Child Health and Human Development Extramural Research).

How much total funding is estimated for this opportunity?

The total estimated funding is about $2.5 million.

What is the maximum award amount per award?

The award ceiling is $300,000 per award.

Is cost sharing or matching required?

No. The announcement states there is no cost sharing or matching requirement.

Who is eligible to apply?

Eligibility is broad and includes small businesses; for-profit organizations (including those other than small businesses); nonprofits (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education in those specific nonprofit categories); private and public institutions of higher education; and many types of government entities.

Which types of government entities are eligible?

Eligible government entities include state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.

Are Tribal entities eligible?

Yes. Eligibility includes federally recognized tribal governments, other Indian/Native American tribal governments, and tribally controlled colleges and universities.

Are minority-serving institutions and special organization types included?

Yes. The eligibility section calls out Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), and faith-based or community-based organizations.

Are U.S. territories or possessions eligible?

Yes. U.S. territories or possessions are listed among eligible applicants.

Are non-U.S. (foreign) organizations allowed to apply?

Yes. The announcement allows non-domestic (non-U.S.) entities (foreign organizations).

Why might NIH allow foreign organizations to apply?

Based on the description, allowing non-U.S. entities signals interest in drawing on specialized global expertise (for example in imaging, biomarker development, computational methods, or device engineering) that could accelerate progress in placental assessment.

What are the key dates listed for this opportunity?

The original posting date is January 29, 2015. The announcement was created February 26, 2015. The key dates shown include an original closing date of March 31, 2015, a current closing date of February 26, 2015, and an archive date of March 26, 2015.

Is this a time-limited solicitation?

Yes. The presence of closing and archive dates indicates it was a time-limited solicitation.

Where can applicants find the official NIH announcement?

The official announcement link is http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-15-032.html.

Who should be contacted for access or technical issues with the online posting?

For access or technical issues with the online posting, NIH lists the Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

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