Opportunity Information: Apply for RFA IP 11 011
Apply for RFA IP 11 011
- The Centers for Disease Control and Prevention in the health sector is offering a public funding opportunity titled "The Incidence and Etiology of Influenza Associated Community Acquired Pneumonia in Hospitalized Persons Study" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.283 Centers for Disease Control and PreventionInvestigations and Technical Assistance.
- This funding opportunity was created on Jan 10, 2011 and posted on Jan 10, 2011.
- Applicants must submit their applications by Mar 15, 2011 On time submission requires that electronic applications be error free and made available to CDC for processing from eRA Commons on or before the deadline date. Applications must be submitted to and validated successfully by Grants.gov/eRA Commons no later than 500 PM Eastern Time. Note.HHS/CDC grant submission procedures do not provide a period of time beyond the application due date to correct any error or warning notices of noncompliance with application instructions that are identified by Grants.gov or eRA systems (i.e., error correction window).. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- These 4 sites have already been funded in FY09 and FY10 and therefore are uniquely qualified to complete this work. Vanderbilt University Northwestern University St. Jude Children s Research Hospital University of Utah
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Opportunity Summary:
The grant opportunity titled "The Incidence and Etiology of Influenza Associated Community Acquired Pneumonia in Hospitalized Persons Study" (Funding Opportunity Number RFA IP 11 011) is a CDC discretionary funding announcement focused on improving how the United States measures and understands severe pneumonia that is acquired in the community and leads to hospitalization, particularly cases associated with influenza. The underlying public health rationale is that pneumonia and influenza together rank as the eighth leading cause of death nationally and remain the leading cause of death from infectious diseases. At the same time, hospitalization trends based on ICD-9 discharge codes for pneumonia and influenza have been rising among older adults, suggesting a growing burden in populations that are already at higher risk for complications, hospitalization, and death.
A central problem the CDC is aiming to address is that existing estimates do not fully capture the true incidence of community-acquired pneumonia or the subset of pneumonia that is associated with influenza when modern, more sensitive diagnostic testing is used. Administrative coding data can be useful for tracking trends, but codes do not reliably identify the causative pathogen and may miss or misclassify influenza-associated disease. The opportunity highlights gaps in three main areas: the real-world incidence of community-acquired pneumonia, accurate rates of hospitalized influenza-associated pneumonia that incorporate sensitive diagnostics, and an up-to-date picture of the relative contributions of different pathogens causing pneumonia in hospitalized patients. In practical terms, the project is designed to move beyond broad syndrome coding and toward lab-supported, pathogen-specific epidemiology.
The intended impact is policy-relevant. By clarifying which pathogens are driving hospitalized community-acquired pneumonia, and how often influenza is involved, findings can guide vaccination strategies (for example, influenza vaccination and pneumococcal vaccination policies), inform clinical and public health approaches to antimicrobial use, and support stewardship efforts. Better etiologic information can reduce unnecessary antibiotic prescribing when bacterial infection is unlikely, and it can also help target antibiotics more appropriately when bacterial pathogens are implicated. This matters because inappropriate or excessive antibiotic use contributes to antimicrobial resistance, and pneumonia is one of the most common reasons antibiotics are started in hospitalized patients.
From an administrative standpoint, the funding mechanism is a Cooperative Agreement, meaning the CDC expected to have substantial involvement in the conduct of the work compared with a typical grant. The activity category is Health, with an expectation of four awards. The CFDA number listed is 93.283 (CDC Investigations and Technical Assistance). The announcement indicates no cost sharing or matching requirement. While the award ceiling and floor are listed as 0 in the summary data provided, that generally reflects how the opportunity was recorded in the system rather than implying no funding; the key operational point is that it is a CDC cooperative agreement supporting a multi-site study.
Eligibility is restricted and unusually specific. Rather than being open to a broad set of applicants, the CDC states that four sites had already been funded in FY09 and FY10 and are uniquely qualified to complete the work, effectively making this a continuation or targeted expansion of an existing effort. The eligible institutions named are Vanderbilt University, Northwestern University, St. Jude Children s Research Hospital, and the University of Utah. This indicates that the CDC intended to leverage established surveillance infrastructure, clinical networks, and diagnostic capacity already in place at these locations, which is often essential for time-sensitive respiratory disease studies and for ensuring consistency of enrollment, specimen collection, and testing across sites.
Key dates reflect a 2011 application cycle. The opportunity was posted and created on Jan 10, 2011, with an original and current closing date of Mar 15, 2011. Applications were required to be submitted electronically through Grants.gov and validated through eRA Commons by 5:00 PM Eastern Time on the deadline date. The notice emphasizes that submissions had to be error-free by the deadline, and that CDC submission procedures did not include an additional window after the due date to correct Grants.gov or eRA Commons errors or noncompliance issues. The archive date is Apr 14, 2011, meaning the announcement was no longer active after that point.
For applicants needing assistance accessing the full announcement, the contact listed is the CDC Procurement and Grants Office (PGO), Technical Information and Management Section (TIMS), with phone number 770 488 2700 and a general email field indicated but not fully displayed in the text provided. Overall, the opportunity is best understood as a CDC-supported, multi-institution cooperative agreement aimed at producing high-quality, diagnostic-backed estimates of influenza-associated community-acquired pneumonia incidence and etiology in hospitalized persons, with downstream uses in vaccine policy, antimicrobial guidance, and resistance reduction efforts.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The opportunity is titled "The Incidence and Etiology of Influenza Associated Community Acquired Pneumonia in Hospitalized Persons Study."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA IP 11 011.
Which agency is offering this grant opportunity?
This is a CDC (Centers for Disease Control and Prevention) discretionary funding announcement.
What is the main public health focus of the project?
The project focuses on improving how the United States measures and understands severe community-acquired pneumonia that results in hospitalization, particularly pneumonia associated with influenza.
Why is CDC focusing on pneumonia and influenza in this announcement?
The rationale described is that pneumonia and influenza together rank as the eighth leading cause of death nationally and remain the leading cause of death from infectious diseases. The announcement also notes rising hospitalization trends based on ICD-9 discharge codes among older adults, suggesting a growing burden in higher-risk populations.
What problem is the CDC trying to solve with this study?
The CDC is trying to address gaps in existing estimates of (1) the true incidence of community-acquired pneumonia and (2) the rate of hospitalized influenza-associated pneumonia when modern, more sensitive diagnostic testing is used. The CDC also aims to update understanding of which pathogens are causing pneumonia in hospitalized patients.
Why are ICD-9 discharge codes not enough for this work?
The announcement explains that administrative coding data can track trends, but codes do not reliably identify the causative pathogen and may miss or misclassify influenza-associated disease. The study is intended to move beyond broad syndrome coding toward lab-supported, pathogen-specific epidemiology.
What are the key evidence gaps this project is meant to fill?
The opportunity highlights three main gaps: real-world incidence of community-acquired pneumonia, accurate rates of hospitalized influenza-associated pneumonia that incorporate sensitive diagnostics, and an up-to-date picture of the relative contributions of different pathogens causing pneumonia in hospitalized patients.
How could the results be used for public health policy or clinical guidance?
The announcement states that findings can guide vaccination strategies (including influenza and pneumococcal vaccination policies), inform clinical and public health approaches to antimicrobial use, and support antibiotic stewardship by reducing unnecessary antibiotic prescribing when bacterial infection is unlikely and improving targeting when bacterial pathogens are implicated.
How does this relate to antimicrobial resistance?
The announcement links better etiologic information to improved antibiotic stewardship, noting that inappropriate or excessive antibiotic use contributes to antimicrobial resistance and that pneumonia is a common reason antibiotics are initiated in hospitalized patients.
What funding mechanism is being used?
The funding mechanism is a Cooperative Agreement, meaning the CDC expected to have substantial involvement in conducting the work compared with a typical grant.
What is the activity category for this opportunity?
The activity category is Health.
How many awards were expected?
The announcement indicates an expectation of four awards.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 93.283 (CDC Investigations and Technical Assistance).
Is cost sharing or matching required?
No. The announcement indicates there is no cost sharing or matching requirement.
What were the award floor and ceiling amounts?
In the summary data provided, the award ceiling and floor are listed as 0. The description notes this likely reflects how the opportunity was recorded in the system rather than implying there was no funding, and emphasizes that the operational intent was a CDC cooperative agreement supporting a multi-site study.
Who was eligible to apply?
Eligibility was restricted to specific institutions identified by the CDC as uniquely qualified based on prior funding and established capacity. The named eligible institutions are Vanderbilt University, Northwestern University, St. Jude Children's Research Hospital, and the University of Utah.
Was this an open competition for new applicants?
No. The announcement states that four sites had already been funded in FY09 and FY10 and were uniquely qualified to complete the work, indicating a continuation or targeted expansion of an existing effort rather than a broadly open competition.
Why were these specific institutions selected as eligible sites?
The announcement indicates the CDC intended to leverage established surveillance infrastructure, clinical networks, and diagnostic capacity already in place at these locations, which is important for consistent enrollment, specimen collection, and testing across sites.
When was the opportunity posted?
The opportunity was posted (and created) on January 10, 2011.
What was the application deadline?
The original and current closing date listed is March 15, 2011.
What time were applications due on the deadline date?
Applications had to be submitted and validated by 5:00 PM Eastern Time on the deadline date.
How were applications required to be submitted?
Applications were required to be submitted electronically through Grants.gov and validated through eRA Commons.
Was there any extra time after the deadline to fix submission errors?
No. The notice emphasizes that submissions had to be error-free by the deadline, and that CDC submission procedures did not include an additional window after the due date to correct Grants.gov or eRA Commons errors or noncompliance issues.
What is the archive date and what does it mean?
The archive date is April 14, 2011. This indicates the announcement was no longer active after that point.
Who can be contacted for help accessing the full announcement?
The contact listed is the CDC Procurement and Grants Office (PGO), Technical Information and Management Section (TIMS), at 770-488-2700. A general email field is referenced but not fully displayed in the provided text.
In one sentence, what is this opportunity trying to produce?
A CDC-supported, multi-institution cooperative agreement intended to generate high-quality, diagnostic-backed estimates of the incidence and causes (etiology) of influenza-associated community-acquired pneumonia in hospitalized persons, with results intended to inform vaccine policy and antimicrobial guidance.
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