Opportunity Information: Apply for RFA NR 13 002
Apply for RFA NR 13 002
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "The Influence of the Microbiome on Preterm Labor and Delivery (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research.
- This funding opportunity was created on Feb 11, 2013 and posted on Feb 11, 2013.
- Applicants must submit their applications by May 9, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: City or township governments Small businesses Independent school districts Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Private institutions of higher education State governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The NIH funding opportunity RFA-NR-13-002, titled "The Influence of the Microbiome on Preterm Labor and Delivery (R01)," is a discretionary research grant issued by the National Institute of Nursing Research (NINR). It is designed to push forward research on why preterm labor and preterm delivery happen by focusing specifically on the role of the human microbiome. The announcement builds on insights and tools generated by the NIH Human Microbiome Project (HMP), which helped establish that the bacterial communities in and on the human body are not static and, importantly for pregnancy, can shift in composition over time. NINR is essentially asking investigators to use modern microbiome science to clarify whether certain microbial patterns, changes, or disruptions are linked to elevated risk for preterm labor and delivery, and how those microbial factors interact with other known influences on pregnancy outcomes.
At the center of the opportunity is the public health problem of preterm birth, which is highlighted as a leading cause of neonatal mortality and long-term morbidity. The announcement points to the growing evidence that microorganisms may be one meaningful contributor among multiple causes. Because the HMP and related research have shown that bacterial species can shift across pregnancy, the FOA encourages studies that go beyond simply cataloging organisms and instead aim to improve understanding of pregnancy-related microbiome dynamics, identify microbiome features associated with higher risk, and explore how genetic and environmental factors shape those microbial changes. In practical terms, this could include research that looks at how maternal host genetics, immune responses, antibiotic exposure, diet, stress, social and physical environment, comorbidities, and other exposures might influence microbial communities and, in turn, inflammatory or other pathways implicated in the onset of labor earlier than term. The overall goal is to generate knowledge that could eventually support better prediction, prevention, and management strategies for preterm birth.
The FOA strongly encourages interdisciplinary research teams and explicitly notes that nurse scientists should be included in the project team. That emphasis signals NINR's interest in projects that connect mechanistic microbiome science with clinically meaningful questions, patient-centered outcomes, real-world care settings, and translational approaches where nursing research expertise is often central. Applicants are also encouraged to consider partnering with nearby or otherwise accessible NIH Clinical and Translational Science Award (CTSA) hubs and/or other federally funded research centers. This is a practical suggestion meant to strengthen study infrastructure, access specialized core resources (for example, biostatistics, clinical research units, recruitment support, and omics or bioinformatics cores), and improve the likelihood that projects can enroll participants, manage biospecimens, and analyze complex microbiome datasets rigorously.
Administratively, the mechanism is an R01 research project grant. The opportunity falls under CFDA 93.361 (Nursing Research), does not require cost sharing or matching, and lists an award ceiling of $350,000. The FOA was posted February 11, 2013, with an original and current closing date of May 9, 2013, and an archive date of June 9, 2013, meaning it is no longer open but remains useful as a reference point for NINR priorities and the type of microbiome-preterm birth research NIH has sought to stimulate.
Eligibility is broad across U.S.-based organizations and governmental entities. Eligible applicants include a wide range of public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, with distinctions noted in the eligibility list), small businesses, for-profit organizations other than small businesses, and multiple levels of government (state, county, city or township, special districts, and certain housing authorities). The FOA also calls out additional eligible categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based and community-based organizations and eligible federal agencies. At the same time, it clearly excludes non-U.S. entities: foreign institutions are not eligible, non-domestic components of U.S. organizations are not eligible, and foreign components are not allowed as defined in the NIH Grants Policy Statement.
For applicants seeking the full original announcement text and requirements, the FOA provides an NIH link (http://grants.nih.gov/grants/guide/rfa-files/RFA-NR-13-002.html). For access or technical issues related to the announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: RFA-NR-13-002 - The Influence of the Microbiome on Preterm Labor and Delivery (R01)
What is RFA-NR-13-002?
RFA-NR-13-002 is an NIH funding opportunity announcement titled "The Influence of the Microbiome on Preterm Labor and Delivery (R01)." It was issued by the National Institute of Nursing Research (NINR) as a discretionary research grant using the R01 mechanism.
Which NIH institute is sponsoring this opportunity?
The opportunity is sponsored by the National Institute of Nursing Research (NINR).
What research topic is the FOA focused on?
The FOA focuses on understanding why preterm labor and preterm delivery occur, specifically by examining the role of the human microbiome and how microbial patterns, changes, or disruptions may relate to elevated risk for preterm birth.
How does the NIH Human Microbiome Project (HMP) relate to this FOA?
The announcement builds on insights and tools generated by the NIH Human Microbiome Project (HMP), including the understanding that bacterial communities in and on the human body can shift over time, including across pregnancy.
Why is preterm birth emphasized in this funding opportunity?
Preterm birth is highlighted as a major public health problem and is described as a leading cause of neonatal mortality and long-term morbidity. The FOA points to growing evidence that microorganisms may be one meaningful contributor among multiple causes.
What types of microbiome questions does NINR want investigators to address?
NINR is encouraging studies that move beyond simply cataloging organisms and instead aim to clarify pregnancy-related microbiome dynamics, identify microbiome features associated with higher risk for preterm labor/delivery, and explore how microbial factors interact with other influences on pregnancy outcomes.
Does the FOA encourage research on how the microbiome changes across pregnancy?
Yes. The FOA specifically draws on evidence that bacterial species can shift across pregnancy and encourages research that improves understanding of these pregnancy-related microbiome dynamics.
What kinds of interacting factors does the FOA mention alongside the microbiome?
The FOA describes a broad set of factors that may shape microbial communities and pregnancy outcomes, including maternal host genetics, immune responses, antibiotic exposure, diet, stress, social and physical environment, comorbidities, and other exposures. It also notes interest in how these factors may relate to inflammatory or other pathways implicated in the onset of labor earlier than term.
What is the overall goal of the research supported by this FOA?
The stated goal is to generate knowledge that could eventually support better prediction, prevention, and management strategies for preterm birth by clarifying microbiome-related mechanisms and risk patterns.
What grant mechanism is being used?
The funding mechanism is an R01 research project grant.
What is the CFDA number associated with this opportunity?
The FOA is listed under CFDA 93.361 (Nursing Research).
Is cost sharing or matching required?
No. The opportunity states that it does not require cost sharing or matching.
What is the award ceiling listed in the FOA?
The FOA lists an award ceiling of $350,000.
When was the FOA posted?
The FOA was posted on February 11, 2013.
What were the closing date and archive date?
The FOA shows an original and current closing date of May 9, 2013, and an archive date of June 9, 2013.
Is this funding opportunity still open?
No. Based on the listed closing and archive dates, it is no longer open. The archived announcement may still be useful as a reference point for NINR priorities and the types of microbiome and preterm birth research NIH has sought to stimulate.
Who is eligible to apply?
Eligibility is broad for U.S.-based organizations and governmental entities. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status as distinguished in the eligibility list), small businesses, for-profit organizations other than small businesses, and multiple levels of government (state, county, city or township, special districts, and certain housing authorities).
Are minority-serving institutions and community organizations included in eligibility?
Yes. The FOA calls out eligibility categories including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations, and eligible federal agencies.
Are foreign institutions or foreign components eligible?
No. The FOA excludes non-U.S. entities: foreign institutions are not eligible, non-domestic components of U.S. organizations are not eligible, and foreign components are not allowed as defined in the NIH Grants Policy Statement.
Does the FOA encourage interdisciplinary teams?
Yes. The FOA strongly encourages interdisciplinary research teams.
Does the FOA specifically mention nurse scientists?
Yes. It explicitly notes that nurse scientists should be included in the project team, signaling NINR's interest in connecting mechanistic microbiome science with clinically meaningful and patient-centered questions and translational approaches where nursing research expertise is central.
Does the FOA suggest partnering with CTSA hubs or other centers?
Yes. Applicants are encouraged to consider partnering with nearby or otherwise accessible NIH Clinical and Translational Science Award (CTSA) hubs and/or other federally funded research centers to strengthen infrastructure and access specialized resources.
What types of resources are mentioned as potential benefits of CTSA or similar partnerships?
The FOA mentions resources such as biostatistics support, clinical research units, recruitment support, and omics or bioinformatics cores, as well as practical strengths like participant enrollment capability, biospecimen management, and rigorous analysis of complex microbiome datasets.
Where can applicants find the full original FOA text?
The FOA provides this NIH link to the original announcement: http://grants.nih.gov/grants/guide/rfa-files/RFA-NR-13-002.html
Who is the contact for access or technical issues related to the announcement?
For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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