Opportunity Information: Apply for RFA CA 09 011
Apply for RFA CA 09 011
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "The Integrative Cancer Biology Program (ICBP) Centers for Cancer Systems Biology (CCSB) (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.396 Cancer Biology Research.
- This funding opportunity was created on Mar 6, 2009 and posted on Mar 6, 2009.
- Applicants must submit their applications by Jun 18, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- Eligible applicants include: State governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Regional Organizations U.S. Territory or Possession.
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Opportunity Summary:
The Integrative Cancer Biology Program (ICBP) Centers for Cancer Systems Biology (CCSB) (U54) funding opportunity (RFA-CA-09-011) is a National Cancer Institute (NCI), National Institutes of Health (NIH) initiative designed to build interdisciplinary research centers that use systems biology and advanced computational approaches to better understand cancer. The CCSBs are intended to serve as the central hubs of the continuing ICBP effort, with a program-level goal of accelerating cancer research by bringing together experimental biology, quantitative modeling, and computation in a tightly integrated way. A key emphasis in this re-issuance is moving beyond descriptive models toward predictive computational modeling, meaning applicants are expected to develop approaches that can forecast cancer-related behaviors or outcomes in a way that can be tested, refined, and ultimately used to guide research and, where relevant, translational decision-making.
Applications must be organized around an overarching cancer biology problem rather than a loose collection of independent projects. The center structure is required to include three integrated components that reinforce each other. First, there must be an experimental systems biology component that generates data and tests hypotheses using experimental methods appropriate for complex biological systems. Second, there must be a mathematical modeling and/or computer simulation component that is directly linked to the experimental work and focused on the same basic or translational research area, with the expectation that modeling and experimentation operate in a feedback loop (models shaping experiments, experiments improving models). Third, each center must include an education and outreach component that supports the CCSB goals, such as training activities, knowledge dissemination, or community-building efforts that help grow capacity in interdisciplinary cancer systems biology. The overall expectation is that these components are not parallel efforts but are designed to function as one integrated program capable of generating mechanistic insight and producing validated, usable predictive models relevant to cancer.
Because the award mechanism is a U54 cooperative agreement, the program is structured for substantial NIH/NCI involvement and coordination, rather than a standard investigator-initiated grant with minimal agency interaction. Funded centers are expected to actively participate in the broader ICBP consortium and to coordinate with other NCI programs. This includes sharing resources, knowledge, and technical skills, and engaging in collaborative interactions that help the program function as a networked community rather than isolated centers. In practice, this kind of consortium expectation typically implies commitments to common standards where appropriate, regular cross-center communication, and contributions that enable other groups to build on the center’s tools, data streams, or modeling approaches.
From an administrative standpoint, the opportunity falls under a discretionary funding category and is listed under education and health activity categories, reflecting the combination of research, training, and outreach expectations. The CFDA number is 93.396 (Cancer Biology Research). The announcement was posted March 6, 2009, with an original and current closing date of June 18, 2009, and an archive date of July 19, 2009. The listed award ceiling is $2,000,000, and there is no cost sharing or matching requirement indicated, which means applicants are not required to provide non-federal matching funds as a condition of the award.
Eligibility is broad and includes public and private institutions of higher education, public/state-controlled institutions of higher education, nonprofits with and without 501(c)(3) status (with specified limits), small businesses, for-profit organizations other than small businesses, and state and county governments. The eligibility listing also includes additional categories such as eligible federal agencies, regional organizations, and U.S. territories or possessions, as further described in the full announcement. This breadth is consistent with the center-based, interdisciplinary nature of the program, where strong applications may come from universities, research institutes, nonprofit research organizations, and other entities capable of assembling integrated experimental and computational teams.
In short, this FOA aims to create and support center-scale teams that can tackle major cancer biology questions using a combined strategy of experimental systems biology, rigorous mathematical/computational modeling, and deliberate education/outreach. The intended impact is to establish a sustained interdisciplinary focus that improves the understanding of cancer as a complex system and advances the development of predictive models that can ultimately contribute to better cancer research strategies and management approaches. The full announcement and official details were provided through NIH Grants guidance at the link associated with RFA-CA-09-011.
Frequently Asked Questions (FAQs)
What is the Integrative Cancer Biology Program (ICBP) Centers for Cancer Systems Biology (CCSB) (U54) funding opportunity?
It is a National Cancer Institute (NCI), National Institutes of Health (NIH) initiative (RFA-CA-09-011) to build interdisciplinary research centers that use systems biology and advanced computational approaches to better understand cancer. The CCSBs are intended to serve as central hubs of the continuing ICBP effort.
What is the main goal of the CCSB program?
The program-level goal is to accelerate cancer research by tightly integrating experimental biology, quantitative modeling, and computation within center-scale teams, enabling deeper mechanistic understanding of cancer as a complex system.
What is a key emphasis in this re-issuance of the FOA?
A key emphasis is moving beyond descriptive models toward predictive computational modeling. Applicants are expected to develop approaches that can forecast cancer-related behaviors or outcomes, and that can be tested and refined through experiments.
How should an application be organized?
Applications must be organized around an overarching cancer biology problem rather than a loose collection of independent projects. The different activities are expected to function as one integrated program.
What center structure is required for a CCSB application?
Each proposed center must include three integrated components that reinforce each other: (1) an experimental systems biology component, (2) a mathematical modeling and/or computer simulation component, and (3) an education and outreach component.
What is expected in the experimental systems biology component?
The experimental component is expected to generate data and test hypotheses using experimental methods appropriate for complex biological systems, supporting the center's overarching cancer biology problem.
What is expected in the mathematical modeling and/or computer simulation component?
The modeling/simulation component must be directly linked to the experimental work and focused on the same basic or translational research area. Modeling and experimentation are expected to operate in a feedback loop, where models shape experiments and experimental results improve models.
What is meant by a modeling-experiment feedback loop?
It means the computational or mathematical models are used to guide what experiments should be done (for example, suggesting which variables or perturbations to test), and then experimental outcomes are used to validate, refine, or revise the models so they become more accurate and predictive.
What is expected in the education and outreach component?
The education and outreach component must support CCSB goals through activities such as training, knowledge dissemination, or community-building that helps grow capacity in interdisciplinary cancer systems biology.
Are the three required components allowed to operate independently?
No. The expectation is that these components are not parallel, standalone efforts. They must be designed to function as one integrated program that generates mechanistic insight and produces validated, usable predictive models relevant to cancer.
What award mechanism is used for this opportunity?
The opportunity uses the U54 cooperative agreement mechanism.
What does it mean that this is a U54 cooperative agreement?
It means the program is structured for substantial NIH/NCI involvement and coordination, rather than being a standard investigator-initiated grant with minimal agency interaction.
What consortium or collaboration expectations apply to funded centers?
Funded centers are expected to actively participate in the broader ICBP consortium and coordinate with other NCI programs. This includes sharing resources, knowledge, and technical skills, and engaging in collaborative interactions that help the program function as a networked community rather than isolated centers.
What kinds of practical commitments may be implied by the consortium expectations?
The description suggests expectations such as regular cross-center communication, contributions that enable other groups to build on a center's tools, data streams, or modeling approaches, and using common standards where appropriate.
What are the activity categories associated with this opportunity?
It is listed under education and health activity categories, reflecting the combination of research, training, and outreach expectations.
What is the CFDA number for this opportunity?
The CFDA number is 93.396 (Cancer Biology Research).
When was the announcement posted and what were the key dates?
The announcement was posted March 6, 2009. The original and current closing date was June 18, 2009, and the archive date was July 19, 2009.
What is the award ceiling listed in the opportunity?
The listed award ceiling is $2,000,000.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement indicated, meaning applicants are not required to provide non-federal matching funds as a condition of the award.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education (including public/state-controlled institutions), nonprofits with and without 501(c)(3) status (with specified limits), small businesses, for-profit organizations other than small businesses, and state and county governments. Additional categories listed include eligible federal agencies, regional organizations, and U.S. territories or possessions, as further described in the full announcement.
What types of organizations are well positioned to compete for a CCSB award?
Organizations capable of assembling integrated experimental and computational teams are well positioned, including universities, research institutes, nonprofit research organizations, and other entities that can support center-based, interdisciplinary research plus education/outreach.
What kind of science is this FOA trying to advance?
This FOA aims to advance cancer systems biology by combining experimental systems biology with rigorous mathematical and computational modeling, with a particular focus on producing predictive models that are validated and usable.
Does the FOA emphasize basic research, translational research, or both?
It references both basic and translational research areas, with the expectation that modeling and experimental work are focused on the same basic or translational area and that predictive models may help guide research and, where relevant, translational decision-making.
Where can applicants find the official details?
The full announcement and official details were provided through NIH Grants guidance at the link associated with RFA-CA-09-011.
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